dbPTM

ACTH_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ACTH_HUMAN
UniProt AC	P63267
Protein Name	Actin, gamma-enteric smooth muscle
Gene Name	ACTG2
Organism	Homo sapiens (Human).
Sequence Length	376
Subcellular Localization	Cytoplasm, cytoskeleton.
Protein Description	Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells..
Protein Sequence	MCEEETTALVCDNGSGLCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHSFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKPEYDEAGPSIVHRKCF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MCEEETTAL ------CCCCCCEEE	10.16	-
3	Acetylation	-----MCEEETTALV -----CCCCCCEEEE	58.53	22223895
34	Phosphorylation	APRAVFPSIVGRPRH CCCCCCHHHCCCCCC	20.59	30266825
45	Oxidation	RPRHQGVMVGMGQKD CCCCCCEEEECCCCC	2.49	-
45	Sulfoxidation	RPRHQGVMVGMGQKD CCCCCCEEEECCCCC	2.49	28183972
48	Oxidation	HQGVMVGMGQKDSYV CCCEEEECCCCCCCC	3.32	-
48	Sulfoxidation	HQGVMVGMGQKDSYV CCCEEEECCCCCCCC	3.32	28183972
51	Acetylation	VMVGMGQKDSYVGDE EEEECCCCCCCCCCH	42.80	7213969
51	Methylation	VMVGMGQKDSYVGDE EEEECCCCCCCCCCH	42.80	-
51	Ubiquitination	VMVGMGQKDSYVGDE EEEECCCCCCCCCCH	42.80	27667366
53	Phosphorylation	VGMGQKDSYVGDEAQ EECCCCCCCCCCHHH	28.84	23401153
54	Phosphorylation	GMGQKDSYVGDEAQS ECCCCCCCCCCHHHC	20.70	27273156
61	Phosphorylation	YVGDEAQSKRGILTL CCCCHHHCCCCEEEE	31.22	23401153
62	Sumoylation	VGDEAQSKRGILTLK CCCHHHCCCCEEEEE	42.43	-
62	Acetylation	VGDEAQSKRGILTLK CCCHHHCCCCEEEEE	42.43	7215583
62	Neddylation	VGDEAQSKRGILTLK CCCHHHCCCCEEEEE	42.43	32015554
62	Sumoylation	VGDEAQSKRGILTLK CCCHHHCCCCEEEEE	42.43	-
62	Ubiquitination	VGDEAQSKRGILTLK CCCHHHCCCCEEEEE	42.43	21906983
67	Phosphorylation	QSKRGILTLKYPIEH HCCCCEEEEECEECC	21.20	22617229
69	Acetylation	KRGILTLKYPIEHGI CCCEEEEECEECCCC	43.69	8269473
69	Methylation	KRGILTLKYPIEHGI CCCEEEEECEECCCC	43.69	-
69	Ubiquitination	KRGILTLKYPIEHGI CCCEEEEECEECCCC	43.69	23000965
70	Phosphorylation	RGILTLKYPIEHGII CCEEEEECEECCCCC	16.74	18180459
71	Ubiquitination	GILTLKYPIEHGIIT CEEEEECEECCCCCC	24.73	21890473
71	Ubiquitination	GILTLKYPIEHGIIT CEEEEECEECCCCCC	24.73	27667366
74	Methylation	TLKYPIEHGIITNWD EEECEECCCCCCCHH	33.21	31993215
76	Ubiquitination	KYPIEHGIITNWDDM ECEECCCCCCCHHHH	3.66	22817900
78	Phosphorylation	PIEHGIITNWDDMEK EECCCCCCCHHHHHH	28.47	36012735
83	Sulfoxidation	IITNWDDMEKIWHHS CCCCHHHHHHHHHHH	5.39	28183972
85	Acetylation	TNWDDMEKIWHHSFY CCHHHHHHHHHHHHH	44.45	7213979
85	Methylation	TNWDDMEKIWHHSFY CCHHHHHHHHHHHHH	44.45	-
85	Ubiquitination	TNWDDMEKIWHHSFY CCHHHHHHHHHHHHH	44.45	16196087
90	Phosphorylation	MEKIWHHSFYNELRV HHHHHHHHHHHCCCC	19.28	26657352
92	Nitration	KIWHHSFYNELRVAP HHHHHHHHHCCCCCC	15.67	-
92	Phosphorylation	KIWHHSFYNELRVAP HHHHHHHHHCCCCCC	15.67	27259358
96	Methylation	HSFYNELRVAPEEHP HHHHHCCCCCCCCCC	19.17	-
104	Phosphorylation	VAPEEHPTLLTEAPL CCCCCCCCCCCCCCC	35.99	26437602
107	Phosphorylation	EEHPTLLTEAPLNPK CCCCCCCCCCCCCCC	32.96	21406692
114	Acetylation	TEAPLNPKANREKMT CCCCCCCCCCHHHHH	58.16	30585405
114	Ubiquitination	TEAPLNPKANREKMT CCCCCCCCCCHHHHH	58.16	27667366
119	Ubiquitination	NPKANREKMTQIMFE CCCCCHHHHHHHHHH	43.97	22817900
120	Sulfoxidation	PKANREKMTQIMFET CCCCHHHHHHHHHHH	2.60	28183972
121	Phosphorylation	KANREKMTQIMFETF CCCHHHHHHHHHHHC	26.47	-
124	Sulfoxidation	REKMTQIMFETFNVP HHHHHHHHHHHCCHH	1.46	28183972
127	Phosphorylation	MTQIMFETFNVPAMY HHHHHHHHCCHHHHH	14.83	-
133	Sulfoxidation	ETFNVPAMYVAIQAV HHCCHHHHHHHHHHH	1.95	28183972
144	Phosphorylation	IQAVLSLYASGRTTG HHHHHHHHHCCCCEE	8.71	30803931
149	Ubiquitination	SLYASGRTTGIVLDS HHHHCCCCEEEEEEC	32.66	21890473
149	Phosphorylation	SLYASGRTTGIVLDS HHHHCCCCEEEEEEC	32.66	26657352
149	Ubiquitination	SLYASGRTTGIVLDS HHHHCCCCEEEEEEC	32.66	21963094
150	Phosphorylation	LYASGRTTGIVLDSG HHHCCCCEEEEEECC	24.45	26437602
156	Phosphorylation	TTGIVLDSGDGVTHN CEEEEEECCCCCCCC	34.32	10632791
161	Phosphorylation	LDSGDGVTHNVPIYE EECCCCCCCCCCEEC	17.17	26437602
167	Phosphorylation	VTHNVPIYEGYALPH CCCCCCEECCCCHHH	9.38	7561247
170	Phosphorylation	NVPIYEGYALPHAIM CCCEECCCCHHHHHH	7.94	7330091
171	Ubiquitination	VPIYEGYALPHAIMR CCEECCCCHHHHHHH	26.02	22817900
173	Ubiquitination	IYEGYALPHAIMRLD EECCCCHHHHHHHHH	13.49	22817900
187	Phosphorylation	DLAGRDLTDYLMKIL HCCCCCHHHHHHHHH	27.21	28152594
189	Phosphorylation	AGRDLTDYLMKILTE CCCCHHHHHHHHHHH	11.94	26846344
191	Sulfoxidation	RDLTDYLMKILTERG CCHHHHHHHHHHHCC	1.75	31801345
192	Acetylation	DLTDYLMKILTERGY CHHHHHHHHHHHCCC	31.78	22646707
192	Methylation	DLTDYLMKILTERGY CHHHHHHHHHHHCCC	31.78	-
192	Ubiquitination	DLTDYLMKILTERGY CHHHHHHHHHHHCCC	31.78	21906983
195	Phosphorylation	DYLMKILTERGYSFV HHHHHHHHHCCCCCE	27.40	46158449
196	Ubiquitination	YLMKILTERGYSFVT HHHHHHHHCCCCCEE	40.43	22817900
197	Methylation	LMKILTERGYSFVTT HHHHHHHCCCCCEEH	44.08	-
197	Phosphorylation	LMKILTERGYSFVTT HHHHHHHCCCCCEEH	44.08	32142685
199	Phosphorylation	KILTERGYSFVTTAE HHHHHCCCCCEEHHC	12.73	54893
200	Phosphorylation	ILTERGYSFVTTAER HHHHCCCCCEEHHCH	18.96	36642193
203	Phosphorylation	ERGYSFVTTAEREIV HCCCCCEEHHCHHHH	20.48	26657352
204	Phosphorylation	RGYSFVTTAEREIVR CCCCCEEHHCHHHHH	22.63	28857561
214	Acetylation	REIVRDIKEKLCYVA HHHHHHHHHHHCEEE	53.75	11921233
214	Ubiquitination	REIVRDIKEKLCYVA HHHHHHHHHHHCEEE	53.75	21906983
216	Acetylation	IVRDIKEKLCYVALD HHHHHHHHHCEEEEE	38.56	7910623
216	Methylation	IVRDIKEKLCYVALD HHHHHHHHHCEEEEE	38.56	-
216	Ubiquitination	IVRDIKEKLCYVALD HHHHHHHHHCEEEEE	38.56	22817900
218	Glutathionylation	RDIKEKLCYVALDFE HHHHHHHCEEEEECC	3.68	22555962
219	Phosphorylation	DIKEKLCYVALDFEN HHHHHHCEEEEECCH	10.13	29396449
230	Phosphorylation	DFENEMATAASSSSL ECCHHHHHHCCCCCC	22.80	26657352
233	Phosphorylation	NEMATAASSSSLEKS HHHHHHCCCCCCCHH	28.43	26657352
234	Phosphorylation	EMATAASSSSLEKSY HHHHHCCCCCCCHHE	21.15	35096073
235	Phosphorylation	MATAASSSSLEKSYE HHHHCCCCCCCHHEE	36.13	26657352
236	Phosphorylation	ATAASSSSLEKSYEL HHHCCCCCCCHHEEC	42.36	29396449
239	Ubiquitination	ASSSSLEKSYELPDG CCCCCCCHHEECCCC	64.73	22817900
240	Phosphorylation	SSSSLEKSYELPDGQ CCCCCCHHEECCCCC	17.92	29255136
241	Nitration	SSSLEKSYELPDGQV CCCCCHHEECCCCCE	32.33	-
241	Phosphorylation	SSSLEKSYELPDGQV CCCCCHHEECCCCCE	32.33	29255136
249	Ubiquitination	ELPDGQVITIGNERF ECCCCCEEEECCCEE	1.46	22505724
250	Phosphorylation	LPDGQVITIGNERFR CCCCCEEEECCCEEC	24.79	26846344
261	Phosphorylation	ERFRCPETLFQPSFI CEECCCCHHCCCCCC	20.29	-
266	Phosphorylation	PETLFQPSFIGMESA CCHHCCCCCCCHHCC	20.79	46158533
272	Phosphorylation	PSFIGMESAGIHETT CCCCCHHCCCCCCCC	23.93	22210691
273	Ubiquitination	SFIGMESAGIHETTY CCCCHHCCCCCCCCC	13.98	21890473
273	Neddylation	SFIGMESAGIHETTY CCCCHHCCCCCCCCC	13.98	32015554
273	Ubiquitination	SFIGMESAGIHETTY CCCCHHCCCCCCCCC	13.98	32142685
279	Phosphorylation	SAGIHETTYNSIMKC CCCCCCCCCHHHHCC	20.09	-
280	Phosphorylation	AGIHETTYNSIMKCD CCCCCCCCHHHHCCC	17.84	3828983
282	Phosphorylation	IHETTYNSIMKCDID CCCCCCHHHHCCCCE	17.41	32645325
284	Ubiquitination	ETTYNSIMKCDIDIR CCCCHHHHCCCCEEC	3.38	21890473
284	Neddylation	ETTYNSIMKCDIDIR CCCCHHHHCCCCEEC	3.38	32015554
284	Ubiquitination	ETTYNSIMKCDIDIR CCCCHHHHCCCCEEC	3.38	27667366
286	Ubiquitination	TYNSIMKCDIDIRKD CCHHHHCCCCEECHH	2.83	21890473
286	Neddylation	TYNSIMKCDIDIRKD CCHHHHCCCCEECHH	2.83	32015554
286	Ubiquitination	TYNSIMKCDIDIRKD CCHHHHCCCCEECHH	2.83	32142685
292	Ubiquitination	KCDIDIRKDLYANNV CCCCEECHHHHHCCC	53.04	22505724
294	Ubiquitination	DIDIRKDLYANNVLS CCEECHHHHHCCCCC	4.95	25015289
295	Phosphorylation	IDIRKDLYANNVLSG CEECHHHHHCCCCCC	19.88	20563989
301	Phosphorylation	LYANNVLSGGTTMYP HHHCCCCCCCCCCCC	30.78	21406692
304	Phosphorylation	NNVLSGGTTMYPGIA CCCCCCCCCCCCCHH	16.35	21406692
305	Phosphorylation	NVLSGGTTMYPGIAD CCCCCCCCCCCCHHH	20.27	21406692
307	Phosphorylation	LSGGTTMYPGIADRM CCCCCCCCCCHHHHH	9.01	20563997
316	Sumoylation	GIADRMQKEITALAP CHHHHHHHHHHHHCC	41.56	-
316	Acetylation	GIADRMQKEITALAP CHHHHHHHHHHHHCC	41.56	7221453
316	Neddylation	GIADRMQKEITALAP CHHHHHHHHHHHHCC	41.56	32015554
316	Sumoylation	GIADRMQKEITALAP CHHHHHHHHHHHHCC	41.56	-
316	Ubiquitination	GIADRMQKEITALAP CHHHHHHHHHHHHCC	41.56	21906983
319	Phosphorylation	DRMQKEITALAPSTM HHHHHHHHHHCCCCE	19.40	30266825
324	Phosphorylation	EITALAPSTMKIKII HHHHHCCCCEEEEEE	35.21	23401153
325	Phosphorylation	ITALAPSTMKIKIIA HHHHCCCCEEEEEEC	22.79	46158473
327	Sumoylation	ALAPSTMKIKIIAPP HHCCCCEEEEEECCC	40.72	-
327	Acetylation	ALAPSTMKIKIIAPP HHCCCCEEEEEECCC	40.72	7215593
327	Methylation	ALAPSTMKIKIIAPP HHCCCCEEEEEECCC	40.72	-
327	Neddylation	ALAPSTMKIKIIAPP HHCCCCEEEEEECCC	40.72	32015554
327	Sumoylation	ALAPSTMKIKIIAPP HHCCCCEEEEEECCC	40.72	-
327	Ubiquitination	ALAPSTMKIKIIAPP HHCCCCEEEEEECCC	40.72	27667366
329	Sumoylation	APSTMKIKIIAPPER CCCCEEEEEECCCCC	23.65	-
329	Acetylation	APSTMKIKIIAPPER CCCCEEEEEECCCCC	23.65	7692069
329	Neddylation	APSTMKIKIIAPPER CCCCEEEEEECCCCC	23.65	32015554
329	Sumoylation	APSTMKIKIIAPPER CCCCEEEEEECCCCC	23.65	-
329	Ubiquitination	APSTMKIKIIAPPER CCCCEEEEEECCCCC	23.65	32142685
337	Sumoylation	IIAPPERKYSVWIGG EECCCCCCEEEEECH	39.97	-
337	Ubiquitination	IIAPPERKYSVWIGG EECCCCCCEEEEECH	39.97	25015289
349	Phosphorylation	IGGSILASLSTFQQM ECHHHHHHHHHHHHH	21.29	-
363	Phosphorylation	MWISKPEYDEAGPSI HHHCCCCCCCCCCCC	27.84	20058876
369	Phosphorylation	EYDEAGPSIVHRKCF CCCCCCCCCCCCCCC	36.00	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ACTH_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
45	M	Oxidation	-
Oxidation of Met-45 and Met-48 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization.
48	M	Oxidation	-
Oxidation of Met-45 and Met-48 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization.
74	H	Methylation	30626964
Methylated at His-74 by SETD3.
85	K	Methylation	-
Monomethylation at Lys-85 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ACTH_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
NEBU_HUMAN	NEB	physical	25110572

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
155310	Visceral myopathy (VSCM)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ACTH_HUMAN

Related Literatures of Post-Translational Modification

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