ATG5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ATG5_MOUSE
• UniProt AC: Q99J83
• Protein Name: Autophagy protein 5
• Gene Name: Atg5
• Organism: Mus musculus (Mouse).
• Sequence Length: 275
• Subcellular Localization: Cytoplasm . Preautophagosomal structure membrane ; Peripheral membrane protein . The conjugate detaches from the membrane immediately before or after autophagosome formation is completed. Localizes also to discrete punctae along the ciliary axoneme a
• Protein Description: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.; May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD (By similarity).; (Microbial infection) May act as a proviral factor. In association with ATG12, negatively regulates the innate antiviral immune response by impairing the type I IFN production pathway upon vesicular stomatitis virus (VSV) infection..
• Protein Sequence: MTDDKDVLRDVWFGRIPTCFTLYQDEITEREAEPYYLLLPRVSYLTLVTDKVKKHFQKVMRQEDVSEIWFEYEGTPLKWHYPIGLLFDLLASSSALPWNITVHFKSFPEKDLLHCPSKDAVEAHFMSCMKEADALKHKSQVINEMQKKDHKQLWMGLQNDRFDQFWAINRKLMEYPPEENGFRYIPFRIYQTTTERPFIQKLFRPVAADGQLHTLGDLLREVCPSAVAPEDGEKRSQVMIHGIEPMLETPLQWLSEHLSYPDNFLHISIVPQPTD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MTDDKDVL -------CCCHHHHH	9.28	-
44	Phosphorylation	LLLPRVSYLTLVTDK EECCCCCHHHHCHHH	10.80	-
75	Phosphorylation	IWFEYEGTPLKWHYP HHCEECCCCCEECCC	17.32	-
138	Ubiquitination	EADALKHKSQVINEM HHHHHHHHHHHHHHH	40.78	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
75	T	Phosphorylation	Kinase	MAPK14	Q16539	GPS
75	T	Phosphorylation	Kinase	P38A	P47811	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ATG5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ATG5_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CASP8_MOUSE	Casp8	physical	22362782
FADD_MOUSE	Fadd	physical	22362782
A16L1_MOUSE	Atg16l1	physical	12665549
CASP8_MOUSE	Casp8	physical	18946037
RIPK1_MOUSE	Ripk1	physical	18946037
FADD_MOUSE	Fadd	physical	18946037
MLP3A_MOUSE	Map1lc3a	physical	18946037

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.