FADD_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FADD_MOUSE
• UniProt AC: Q61160
• Protein Name: FAS-associated death domain protein
• Gene Name: Fadd
• Organism: Mus musculus (Mouse).
• Sequence Length: 205
• Protein Description: Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis (By similarity). Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling (By similarity)..
• Protein Sequence: MDPFLVLLHSLSGSLSGNDLMELKFLCRERVSKRKLERVQSGLDLFTVLLEQNDLERGHTGLLRELLASLRRHDLLQRLDDFEAGTATAAPPGEADLQVAFDIVCDNVGRDWKRLARELKVSEAKMDGIEEKYPRSLSERVRESLKVWKNAEKKNASVAGLVKALRTCRLNLVADLVEEAQESVSKSENMSPVLRDSTVSSSETP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	Phosphorylation	RKLERVQSGLDLFTV HHHHHHHHCHHHHHH	38.17	23737553
47	Phosphorylation	QSGLDLFTVLLEQND HHCHHHHHHHHHHCC	19.96	22324799
69	Phosphorylation	LLRELLASLRRHDLL HHHHHHHHHHHCHHH	23.52	24719451
183	Phosphorylation	LVEEAQESVSKSENM HHHHHHHHHHCCCCC	21.44	22345495
185	Phosphorylation	EEAQESVSKSENMSP HHHHHHHHCCCCCCC	39.48	22345495
187	Phosphorylation	AQESVSKSENMSPVL HHHHHHCCCCCCCCC	27.05	28833060
190	Oxidation	SVSKSENMSPVLRDS HHHCCCCCCCCCCCC	4.15	17242355
191	Phosphorylation	VSKSENMSPVLRDST HHCCCCCCCCCCCCC	24.36	26824392
197	Phosphorylation	MSPVLRDSTVSSSET CCCCCCCCCCCCCCC	25.03	26643407
198	Phosphorylation	SPVLRDSTVSSSETP CCCCCCCCCCCCCCC	28.79	26643407
200	Phosphorylation	VLRDSTVSSSETP-- CCCCCCCCCCCCC--	28.38	26643407
201	Phosphorylation	LRDSTVSSSETP--- CCCCCCCCCCCC---	28.05	26643407
202	Phosphorylation	RDSTVSSSETP---- CCCCCCCCCCC----	37.67	27087446
204	Phosphorylation	STVSSSETP------ CCCCCCCCC------	35.92	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FADD_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FADD_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FADD_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CFLAR_MOUSE	Cflar	physical	16469705
CASP8_MOUSE	Casp8	physical	16469705
RIPK1_MOUSE	Ripk1	physical	22037414
PIDD1_MOUSE	Pidd1	physical	16183742
ATG5_MOUSE	Atg5	physical	18946037
A16L1_MOUSE	Atg16l1	physical	18946037
CASP8_MOUSE	Casp8	physical	18946037
RIPK1_MOUSE	Ripk1	physical	18946037
MLP3A_MOUSE	Map1lc3a	physical	18946037
ATG12_MOUSE	Atg12	physical	18946037
ATG7_MOUSE	Atg7	physical	18946037
CASP8_MOUSE	Casp8	physical	18708583
BIRC3_MOUSE	Birc3	physical	18708583
CFLAR_MOUSE	Cflar	physical	18708583
RIPK1_MOUSE	Ripk1	physical	24144979
CASP8_MOUSE	Casp8	physical	24144979
KCMA1_MOUSE	Kcnma1	physical	25581503
RIPK1_MOUSE	Ripk1	physical	27458237

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.