PIDD1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PIDD1_MOUSE
• UniProt AC: Q9ERV7
• Protein Name: p53-induced death domain-containing protein 1
• Gene Name: Pidd1
• Organism: Mus musculus (Mouse).
• Sequence Length: 915
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: Promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. Associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. Associates with CASP2/caspase-2 and CRADD/RAIDD, and induces activation of CASP2 which an important regulator in apoptotic pathways..
• Protein Sequence: MAAVLEGQEPEETAAAAEDAATSTLEAVDAGPGAPFLPAGNQLNLDLRPGGCHRLQYLCSQQPPQLLQVEFLRLSTHEDPQLLDDTLAKVPWSLLRLRSLVLKGGQSRGALGACLHGTLTTLPAGLSDLACLAHLDLSFNRLETLPTCVPELHGLDALLLSHNHLSELPEALGALPALTFLTVTHNRLERLPLTLGSLSTLQRLDLSENLLDTIPSEIGNLRSLSELNLASNRLQSLPASLAGLRSLRLLVLHSNLLTSVPTGLVHLPLITRLDLRDNRLRDLPAELLDAPFVRLQGNPLGEASPAPPSPPDISQVPEMPRLLLTSDLDSFLVTPHGCSVTLACGVRLQFPAGATTTPVTIHYRLWLPEPGLVSLGPHDFLLSSVLELQPHGVAFQQDVSLWLLFVPPRVRRCREVVVRTRSNNTWNDLETQLEEEAPKRLWARCQVPHFSWFLVVLRPVSNTCLLPPEGALLCSSGHPGVRVTFPPGVTEEPRQVSMQVVHMAGLELRTLLEESEASVSPLLCLSQSGPPSFLQPVTVQLPLPPGVTGFSLDRSHLHLLYRTPLTTTWDDITTQVALEFTHLYARFQVTHFSWYWLWYTTKTCVGGLARKAWERLRLHRVNLIALQRRRDPEQVLLQCLPRNKVDATLSRLLVRYRGPEPSETVEMFEGEKFFAAFERGIDVDADRPDCVDGRICFVFYSHLKNVKEVYITTALDREAQDVRGQVSFYRGSLPVEVPAEAEAARQRKGTDALWMATLPIKLPRLRGAQGSGQGTDFSLMPLNLGDAETGFLTQSNLLSVASRLGPDWPAVALHLGMPYHKLQRIRHEFRDDLDGQVRHMLFSWAERQTGQPGAVGHLVQALEQSDRRDVAEEVRAILELGRHKYQDSIRRTGLAPEDSTLPGTSASQTPESAQA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAVLEGQE ------CCCCCCCCC		-
225	Phosphorylation	IGNLRSLSELNLASN HHCHHCHHHHCHHCH		28418008
231	Phosphorylation	LSELNLASNRLQSLP HHHHCHHCHHHHCCC		28418008
304	Phosphorylation	GNPLGEASPAPPSPP CCCCCCCCCCCCCCC		-
309	Phosphorylation	EASPAPPSPPDISQV CCCCCCCCCCCHHHC		22006019
595	Phosphorylation	QVTHFSWYWLWYTTK CCEEEEEEEHHHHCC		29895711
599	Phosphorylation	FSWYWLWYTTKTCVG EEEEEHHHHCCCCHH		29895711
600	Phosphorylation	SWYWLWYTTKTCVGG EEEEHHHHCCCCHHH		29895711
727	Phosphorylation	QDVRGQVSFYRGSLP HHHCCCEEEEECCCC		21454597
732	Phosphorylation	QVSFYRGSLPVEVPA CEEEEECCCCCCCCH		21454597

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PIDD1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PIDD1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PIDD1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PCNA_MOUSE	Pcna	physical	21415862

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.