MLP3A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MLP3A_MOUSE
• UniProt AC: Q91VR7
• Protein Name: Microtubule-associated proteins 1A/1B light chain 3A
• Gene Name: Map1lc3a
• Organism: Mus musculus (Mouse).
• Sequence Length: 121
• Subcellular Localization: Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Cytoplasmic vesicle, autophagosome . LC3-II binds to the autophagic membranes..
• Protein Description: Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation..
• Protein Sequence: MPSDRPFKQRRSFADRCKEVQQIRDQHPSKIPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELVKIIRRRLQLNPTQAFFLLVNQHSMVSVSTPIADIYEQEKDEDGFLYMVYASQETFGF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MPSDRPFKQR -----CCCCCCHHHH	44.98	22324799
12	Phosphorylation	RPFKQRRSFADRCKE CCHHHHHHHHHHHHH	27.29	20713600
29	Phosphorylation	QIRDQHPSKIPVIIE HHHHHCCCCCCEEEE	40.88	24224561
49	Ubiquitination	KQLPVLDKTKFLVPD CCCCCCCCCCCCCCC	49.83	-
50	Phosphorylation	QLPVLDKTKFLVPDH CCCCCCCCCCCCCCC	27.05	-
51	Ubiquitination	LPVLDKTKFLVPDHV CCCCCCCCCCCCCCC	42.30	22790023
120	Phosphatidylethanolamine amidation	YASQETFGF------ EEECCCCCC------	34.47	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
12	S	Phosphorylation	Kinase	PKA	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
12	S	Phosphorylation	Phosphorylation at Ser-12 by PKA inhibits conjugation to phosphatidylethanolamine (PE).	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MLP3A_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MAP1A_MOUSE	Map1a	physical	18083104
MAP1B_MOUSE	Map1b	physical	18083104
SQSTM_MOUSE	Sqstm1	physical	18083104
ATG4B_MOUSE	Atg4b	physical	18083104
ATG3_MOUSE	Atg3	physical	18083104
WDFY3_MOUSE	Wdfy3	physical	18083104
SQSTM_MOUSE	Sqstm1	physical	18524774
ATG7_MOUSE	Atg7	physical	18083104

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.