WDFY3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WDFY3_MOUSE
• UniProt AC: Q6VNB8
• Protein Name: WD repeat and FYVE domain-containing protein 3
• Gene Name: Wdfy3
• Organism: Mus musculus (Mouse).
• Sequence Length: 3508
• Subcellular Localization: Nucleus . Cytoplasm, cytosol . Nucleus, PML body . Membrane ; Peripheral membrane protein ; Cytoplasmic side . Perikaryon . Cell projection, axon . Relocalization from the nucleus to the cytosol is stimulated by cellular stress, such as starvation or
• Protein Description: Required for selective macroautophagy (aggrephagy). Acts as an adapter protein by linking specific proteins destined for degradation to the core autophagic machinery members, such as the ATG5-ATG12-ATG16L E3-like ligase, SQSTM1 and LC3. Involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures) (By similarity). Important for normal brain development. [PubMed: 25198012]
• Protein Sequence: MNMVKRIMGRPRQEECSPQDNALGLMHLRRLFTELCHPPRHMTQKEQEEKLYMMLPVFNRVFGNAPPNTMTEKFSDLLQFTTQVSRLMVTEIRRRASNKSTEAASRAIVQFLEINQSEEASRGWMLLTTINLLASSGQKTVDCMTTMSVPSTLVKCLYLFFDLPHVPEAGGGAQNELPLAERRGLLQKAFVQILVKLCSFVSPAEELAQKDDLQLLFSAITSWCPPYNLPWRKSAGEVLMTISRHGLSVNVVKYIHEKECLSTCVQNMQQSDDLSPLEIVEMFAGLSCFLKDSSDVSQTLLDDFRIWQGYNFLCDLLLRLEQGKEAECRDALKDLVSLVTSLTTYGVSELKPAGVTTGAPFLLPGFAVPQPAGKGHSVRNIQAFAVLQNAFLKAKTNFLAQIILDAITNIYMADNANYFILESQHTLSQFAEKISKLPEVQNKYFEMLEFVVFSLNYIPCKELISVSILLKSSSSYHCSIIAMKTLLKFTRHDYIFKDVFREVGLLEVMVNLLHKYAALLKDPAQALNEQGDSRNNSSVEDQKHLALLVMEALTVLLQGSNTNAGIFREFGGARCAHNIVKYPQCRQHALMTIQQLVLSPNGEDDMGTLLGLMHSAPPTELQLKTDILRALLSVLRESHRSRTVFRKVGGFVYITSLLVAMERSLSSPPKNGWEKVSQSQVLELLHTVFCTLTAALRYEPANSHFFKTEIQYEKLADAVRFLGCFSDLRKISAVNVFPSNTQPFQRLLEEGAVSVDSVSPTLRHCSKLFIYLYKVATDSFDSHAEQIPPCLTSESSLPSPWGTPALSRKRHAFHCVSTPPVYPAKNVTDLKLQVTSSPLQSSDAVIIHPGAMLAMLDLLASVGSVTQPEHALDLQLAVANILQSLVHTERNQQVMCEAGLHARLLQRCGAALADEDHSLHPPLQRMFERLASQALEPMVLREFLRLASPLNCGAWDKKLLKQYRVHKPSSLSFEPEMRSSVITSLEGLGSDNVFSSHEDNHYRISKSLVKSAEGSTVPLTRVKCLVSMTTPHDIRLHGSSVTPAFVEFDTSLEGFGCLFLPSLAPHNAPTNNTVTTGLTDGAVVSGMGSGERFFPPPSGLSYSCWFCIEHFSSPPNNHPVRLLTVVRRANSSEQHYVCLAIVLSAKDRSLIVSTKEELLQNYVDDFSEESSFYEILPCCARFRCGELVVEGQWHHLALLMSRGMLKNSTAALYLDGQLVSTVKLHYVHSTPGGSGSANPPVLSTVYAYVGTPPAQRQIASLVWRLGPTHFLEEVLPPSSVTTIYELGPNYVGSFQAVCVPCKDAKSEGVTPSPVSLVAEEKVSFGLYALSVSSLTVARIRKVYNKLDSKAIAKQLGISSHENATPVKLVHNAAGHLNGPARTIGAALIGYLGVRTFVPKPVATTLQYIGGAAAILGLVAMASDVEGLYAAVKALVCVVKSNPLASKEMERIKGYQLLAMLLKKKRSLLNSHILHLTFSLVGTVDSGHETSIIPNSTAFQDLLCDFEVWLHAPYELHLSLFEHFIELLTESSEASKNAKLMREFQLIPKLLLTLRDMSLSQPTIAAISNVLSFLLQGFPNSNDLLRFGQFISSTLPTFAVCEKFVVMEINNEEKPDPGAEEEFGGLVSANLILLRNRLLDILLKLVYTSKEKTNINLQACEELVRTLGFDWIMMFMEEHLHPTTVTAAMRILVVLLSNQSILIKFKEGLSGGGWLEQTDSVLTNKIGTVLGFNVGRSAGGRSTVREINRDACHFPGFLVLQSFLPKHTNVPALYFLLMALFLQQPVSELPENLQVSVPVTSSRCKQGCQFDLDSIWTFIFGVPASSGTVVSSIHNVCTESAFLLLGMLRSMLNSPWQSEEEGSWLREYPVTLMQFFRYLYHNVPDLASMWLSPDFLCALAATVFPFNIRPYSEMVTDLDDEVGSPAEEFKAFAADTGMNRSQSEYCNVGTKTYLTNHPAKKFVFDFMRVLIIDNLCLTPASKQTPLIDLLLEASPERSTRTQQKEFQTHVLDSVMDHLLAADVLLGEDASLPITSGGSYQVLVNNVFYFTQRVVDKLWQGMFNKESKLLIDFIIQLIAQSKRRSQGLSLDAVYHCLNRTILYQFSRAHKTVPQQVALLDSLRVLTVNRNLILGPGNHDQEFISCLAHCLINLHAGSVEGFGLEAEARMTTWHIMIPSDIEPDGGYSQDISEGRQLLIKAVNRVWTELIHSKKQVLEELFKVSLPVNDRGHVDIALARPLIEEAGLKCWQNHLAHEKKCISRGEALVPTTQSKLSRVSSGFGLSKLTGSRRNRKESGLHKHSPSPQEISQWMFTHIAVVRDLVDTQYKEYQERQQNALKYVTEEWCQIECELLRERGLWGPPIGSHLDKWMLEMTEGPCRMRKKMVRNDMFYNHYPYVPETEQEASVGKPARYRRAISYDSKEYYLRLASGNPAIVQDAIVESSEGEATQQEPEHGEDTIAKVKGLVKPPLKRSRSAPDGGDEETQEQLQDQIAESGSIEEEEKTDNATLLRLLEEGEKIQHMYRCARVQGLDTSEGLLLFGKEHFYVIDGFTMTATREIRDIETLPPNMHEPIIPRGARQGPSQLKRTCSIFAYEDIKEVHKRRYLLQPIAVEVFSGDGRNYLLAFQKGIRNKVYQRFLAVVPSLTDSSESVSGQRPNTSVEQGSGLLSTLVGEKSVTQRWERGEISNFQYLMHLNTLAGRSYNDLMQYPVFPWILSDYDSEEVDLTNPKTFRNLAKPMGAQTDERLAQYKKRYKDWEDPNGETPAYHYGTHYSSAMIVASYLVRMEPFTQIFLRLQGGHFDLADRMFHSVREAWYSASKHNMADVKELIPEFFYLPEFLFNSNNFDLGCKQNGTKLGDVILPPWAKGDPREFIRVHREALECDYVSAHLHEWIDLIFGYKQQGPAAVEAVNVFHHLFYEGQVDIYNINDPLKETATIGFINNFGQIPKQLFKKPHPPKRVRSRLNGDNIGISVPPGATSDKIFFHHLDNLRPSLTPVKELKEPVGQIVCTDKGILAVEQNKVLIPPAWNKTFAWGYADLSCRLGTYESDKAVTVYECLSEWGQILCAVCPNPKLVITGGTSTVVCVWEMGTSKEKAKPLTLKQALLGHTDTVTCATASLAYHIIVSGSRDRTCIIWDLNKLSFLTQLRGHRAPVSALCINELTGDIVSCAGTYIHVWSINGNPIVSVNTFTGRSQQIVCCCMSEMNEWDTQNVIVTGHSDGVVRFWRMEFLQVPETPAPEPVEDLEMQEGCPEAQIGQQAQDDDSSDSETEEPSVSQDPKDTSSQPSSTSHRPRAASCRATATWCTDSGSDDSRRWSDQLSLDEKDGFIFVNYSEGQTRAHLQGPLAHPHPNPIEARSYSRLKPGYRWERQLVFRSKLTMHTAFDRKDNTHPAEVTALGVSKDHSRILVGDSRGRVFSWSVSDQPGRSAADHWVKDEGGDSCSGCSVRFSLTERRHHCRNCGQLFCQKCSRFQSEIKRLKISSPVRVCQNCYYSLQHERGAEDGPRNC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
52	Phosphorylation	KEQEEKLYMMLPVFN HHHHHHHHHHHHHHH	7.49	25777480
69	Phosphorylation	FGNAPPNTMTEKFSD HCCCCCCCCHHHHHH	31.10	25777480
71	Phosphorylation	NAPPNTMTEKFSDLL CCCCCCCHHHHHHHH	33.70	25777480
97	Phosphorylation	TEIRRRASNKSTEAA HHHHHHHCCCCHHHH	42.87	29899451
100	Phosphorylation	RRRASNKSTEAASRA HHHHCCCCHHHHHHH	35.41	29899451
105	Phosphorylation	NKSTEAASRAIVQFL CCCHHHHHHHHHHHH	29.32	29899451
581	Ubiquitination	RCAHNIVKYPQCRQH CCCHHHCCCHHHHHH	47.63	-
730	Ubiquitination	GCFSDLRKISAVNVF CCCCCCCCCEEEECC	48.59	-
757	Phosphorylation	EGAVSVDSVSPTLRH CCCCCHHCCCHHHHH	23.49	20415495
759	Phosphorylation	AVSVDSVSPTLRHCS CCCHHCCCHHHHHHH	19.00	22817900
761	Phosphorylation	SVDSVSPTLRHCSKL CHHCCCHHHHHHHHH	28.99	20415495
799	Phosphorylation	TSESSLPSPWGTPAL CCCCCCCCCCCCCCC	38.28	-
807	Phosphorylation	PWGTPALSRKRHAFH CCCCCCCCCCCCEEE	37.55	-
817	Phosphorylation	RHAFHCVSTPPVYPA CCEEEECCCCCCCCC	40.36	29472430
818	Phosphorylation	HAFHCVSTPPVYPAK CEEEECCCCCCCCCC	15.94	22817900
822	Phosphorylation	CVSTPPVYPAKNVTD ECCCCCCCCCCCCCC	11.84	29472430
957	Ubiquitination	LNCGAWDKKLLKQYR CCCCCCCHHHHHHHC	34.32	-
969	Phosphorylation	QYRVHKPSSLSFEPE HHCCCCCCCCCCCHH	49.03	25521595
970	Phosphorylation	YRVHKPSSLSFEPEM HCCCCCCCCCCCHHH	36.24	26824392
972	Phosphorylation	VHKPSSLSFEPEMRS CCCCCCCCCCHHHHH	29.52	20531401
983	Phosphorylation	EMRSSVITSLEGLGS HHHHHHHHHCCCCCC	25.71	25338131
984	Phosphorylation	MRSSVITSLEGLGSD HHHHHHHHCCCCCCC	17.19	25338131
1098	Phosphorylation	ERFFPPPSGLSYSCW CCCCCCCCCCCEEEE	59.13	-
1226	Phosphorylation	VSTVKLHYVHSTPGG EEEEEEEEECCCCCC	15.42	-
1327	Phosphorylation	EKVSFGLYALSVSSL ECCCCEEEEHHHHHH	13.08	21183079
1332	Phosphorylation	GLYALSVSSLTVARI EEEEHHHHHHHHHHH	19.09	22817900
1335	Phosphorylation	ALSVSSLTVARIRKV EHHHHHHHHHHHHHH	17.67	22817900
1935	Phosphorylation	FKAFAADTGMNRSQS HHHHHHHCCCCCCHH	33.34	22324799
1940	Phosphorylation	ADTGMNRSQSEYCNV HHCCCCCCHHHCCCC	32.81	22324799
1942	Phosphorylation	TGMNRSQSEYCNVGT CCCCCCHHHCCCCCC	31.60	25521595
1944	Phosphorylation	MNRSQSEYCNVGTKT CCCCHHHCCCCCCCC	8.45	23984901
1949	Phosphorylation	SEYCNVGTKTYLTNH HHCCCCCCCCCCCCC	18.87	23984901
2083	Phosphorylation	IAQSKRRSQGLSLDA HHHHHHHCCCCCHHH	32.41	26824392
2087	Phosphorylation	KRRSQGLSLDAVYHC HHHCCCCCHHHHHHH	30.90	22807455
2276	Phosphorylation	QSKLSRVSSGFGLSK HHHHHHHHCCCCHHH	24.51	22324799
2277	Phosphorylation	SKLSRVSSGFGLSKL HHHHHHHCCCCHHHH	34.97	25521595
2282	Phosphorylation	VSSGFGLSKLTGSRR HHCCCCHHHHCCCCC	26.46	26643407
2283	Ubiquitination	SSGFGLSKLTGSRRN HCCCCHHHHCCCCCC	55.93	-
2325	Phosphorylation	RDLVDTQYKEYQERQ HHHHHHHHHHHHHHH	14.10	28576409
2326	Acetylation	DLVDTQYKEYQERQQ HHHHHHHHHHHHHHH	39.88	23576753
2416	Phosphorylation	ARYRRAISYDSKEYY CHHEEEECCCCHHHH	23.15	29899451
2472	Phosphorylation	VKPPLKRSRSAPDGG CCCCCCCCCCCCCCC	29.06	27087446
2474	Phosphorylation	PPLKRSRSAPDGGDE CCCCCCCCCCCCCCH	45.45	25521595
2483	Phosphorylation	PDGGDEETQEQLQDQ CCCCCHHHHHHHHHH	35.04	30635358
2494	Phosphorylation	LQDQIAESGSIEEEE HHHHHHHHCCCCHHH	28.90	30635358
2496	Phosphorylation	DQIAESGSIEEEEKT HHHHHHCCCCHHHHC	35.79	30635358
2503	Phosphorylation	SIEEEEKTDNATLLR CCCHHHHCCHHHHHH	37.45	30635358
2507	Phosphorylation	EEKTDNATLLRLLEE HHHCCHHHHHHHHHH	32.36	30635358
2555	Phosphorylation	DGFTMTATREIRDIE ECEEEEECEEECCCC	21.48	-
2730	Phosphorylation	VDLTNPKTFRNLAKP CCCCCHHHHHHHCCC	29.14	22871156
2789	Phosphorylation	LVRMEPFTQIFLRLQ HHCCCCCCHHHHHHC	31.32	-
3100	Phosphorylation	KEKAKPLTLKQALLG HHHCCCCCHHHHHCC	40.20	27149854
3283	O-linked_Glycosylation	SQDPKDTSSQPSSTS CCCCCCCCCCCCCCC	36.79	22645316
3284	Phosphorylation	QDPKDTSSQPSSTSH CCCCCCCCCCCCCCC	48.48	29899451
3287	Phosphorylation	KDTSSQPSSTSHRPR CCCCCCCCCCCCCCC	38.31	29899451
3288	Phosphorylation	DTSSQPSSTSHRPRA CCCCCCCCCCCCCCC	40.38	29899451
3289	Phosphorylation	TSSQPSSTSHRPRAA CCCCCCCCCCCCCCC	32.65	29899451
3290	O-linked_Glycosylation	SSQPSSTSHRPRAAS CCCCCCCCCCCCCCC	21.32	22645316
3290	Phosphorylation	SSQPSSTSHRPRAAS CCCCCCCCCCCCCCC	21.32	29899451
3301	Phosphorylation	RAASCRATATWCTDS CCCCCCEEEEEECCC	12.79	-
3303	Phosphorylation	ASCRATATWCTDSGS CCCCEEEEEECCCCC	19.40	30635358
3306	Phosphorylation	RATATWCTDSGSDDS CEEEEEECCCCCCCC	25.43	30635358
3308	Phosphorylation	TATWCTDSGSDDSRR EEEEECCCCCCCCCC	23.26	22817900
3310	Phosphorylation	TWCTDSGSDDSRRWS EEECCCCCCCCCCHH	42.04	22817900
3313	Phosphorylation	TDSGSDDSRRWSDQL CCCCCCCCCCHHCCC	28.83	30635358
3317	Phosphorylation	SDDSRRWSDQLSLDE CCCCCCHHCCCCCCC	17.42	26824392
3321	Phosphorylation	RRWSDQLSLDEKDGF CCHHCCCCCCCCCCE	28.30	21082442
3450	O-linked_Glycosylation	SGCSVRFSLTERRHH CCCEEEEECCCCCHH	24.66	55414601
3477	Acetylation	SRFQSEIKRLKISSP HHHHHHHHHCCCCCC	47.85	6571733
3482	Phosphorylation	EIKRLKISSPVRVCQ HHHHCCCCCCHHHHC	27.31	22817900
3483	Phosphorylation	IKRLKISSPVRVCQN HHHCCCCCCHHHHCC	30.78	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WDFY3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WDFY3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WDFY3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of WDFY3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3317, AND MASSSPECTROMETRY.
PubMed: 19367708