dbPTM

A16L1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	A16L1_MOUSE
UniProt AC	Q8C0J2
Protein Name	Autophagy-related protein 16-1
Gene Name	Atg16l1
Organism	Mus musculus (Mouse).
Sequence Length	607
Subcellular Localization	Cytoplasm. Preautophagosomal structure membrane Peripheral membrane protein . Recruited to omegasomes membranes by WIPI2. Omegasomes are endoplasmic reticulum connected strutures at the origin of preautophagosomal structures. Localized to preautoph
Protein Description	Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane. [PubMed: 18849966]
Protein Sequence	MSSGLRAADFPRWKRHIAEELRRRDRLQRQAFEEIILQYTKLLEKSDLHSVLTQKLQAEKHDMPNRHEISPGHDGAWNDSQLQEMAQLRIKHQEELTELHKKRGELAQLVIDLNNQMQQKDKEIQMNEAKISEYLQTISDLETNCLDLRTKLQDLEVANQTLKDEYDALQITFTALEEKLRKTTEENQELVTRWMAEKAQEANRLNAENEKDSRRRQARLQKELAEAAKEPLPVEQDDDIEVIVDETSDHTEETSPVRAVSRAATKRLSQPAGGLLDSITNIFGRRSVSSIPVPQDIMDTHPASGKDVRVPTTASYVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEAFGDKCEFKGSLSGSNAGITSIEFDSAGAYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFAGSSCNDIVCTEQCVMSGHFDKKIRFWDIRSESVVREMELLGKITALDLNPERTELLSCSRDDLLKVIDLRTNAVKQTFSAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYVWSVLTGKVEKVLSKQHSSSINAVAWAPSGLHVVSVDKGSRAVLWAQP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
70	Phosphorylation	MPNRHEISPGHDGAW CCCCCCCCCCCCCCC	23.11	26370283
132	Phosphorylation	QMNEAKISEYLQTIS HHCHHHHHHHHHHHH	21.34	28059163
139	Phosphorylation	SEYLQTISDLETNCL HHHHHHHHHHHHHHH	39.26	-
211	Acetylation	RLNAENEKDSRRRQA HCCCCCHHHHHHHHH	73.00	6569509
247	Phosphorylation	IEVIVDETSDHTEET CEEEEECCCCCCCCC	34.68	29899451
248	Phosphorylation	EVIVDETSDHTEETS EEEEECCCCCCCCCC	25.91	23984901
251	Phosphorylation	VDETSDHTEETSPVR EECCCCCCCCCCHHH	40.27	29899451
254	Phosphorylation	TSDHTEETSPVRAVS CCCCCCCCCHHHHHH	31.90	29899451
255	Phosphorylation	SDHTEETSPVRAVSR CCCCCCCCHHHHHHH	25.36	19060867
265 (in isoform 5)	Phosphorylation	-	18.73	26643407
265 (in isoform 2)	Phosphorylation	-	18.73	26643407
268 (in isoform 5)	Phosphorylation	-	6.25	26643407
268 (in isoform 2)	Phosphorylation	-	6.25	26643407
269	Phosphorylation	RAATKRLSQPAGGLL HHHHHHHCCCCCHHH	37.84	26824392
270 (in isoform 5)	Phosphorylation	-	36.13	26643407
270 (in isoform 2)	Phosphorylation	-	36.13	26643407
271 (in isoform 5)	Phosphorylation	-	29.51	26643407
271 (in isoform 2)	Phosphorylation	-	29.51	26643407
278	Phosphorylation	PAGGLLDSITNIFGR CCCHHHHHHHHHHCC	31.14	26824392
280	Phosphorylation	GGLLDSITNIFGRRS CHHHHHHHHHHCCCC	26.64	23984901
287	Phosphorylation	TNIFGRRSVSSIPVP HHHHCCCCCCCCCCC	25.62	25521595
289	Phosphorylation	IFGRRSVSSIPVPQD HHCCCCCCCCCCCCC	24.64	27742792
290	Phosphorylation	FGRRSVSSIPVPQDI HCCCCCCCCCCCCCH	28.84	27742792
300	Phosphorylation	VPQDIMDTHPASGKD CCCCHHHCCCCCCCC	16.63	25619855
304	Phosphorylation	IMDTHPASGKDVRVP HHHCCCCCCCCCCCC	51.32	25619855
339	Phosphorylation	PGSRLLATGGMDRRV CCCCEECCCCCCHHH	33.95	25338131
361	Phosphorylation	DKCEFKGSLSGSNAG CCCEEECCCCCCCCC	21.69	-
371	Phosphorylation	GSNAGITSIEFDSAG CCCCCCEEEEECCHH	20.42	-
445	Phosphorylation	RSKVCIKTVFAGSSC CCCEEEEEECCCCCC	10.84	20469934
450	Phosphorylation	IKTVFAGSSCNDIVC EEEECCCCCCCCEEE	28.43	20469934
451	Phosphorylation	KTVFAGSSCNDIVCT EEECCCCCCCCEEEC	18.93	20469934
458	Phosphorylation	SCNDIVCTEQCVMSG CCCCEEECCHHHHCC	20.42	20469934
464	Phosphorylation	CTEQCVMSGHFDKKI ECCHHHHCCCCCCEE	14.55	20469934
513	Ubiquitination	CSRDDLLKVIDLRTN ECHHHHHHHHHHCCH	44.43	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of A16L1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
139	S	Phosphorylation		-
Phosphorylation at Ser-139 promotes association with the ATG12-ATG5 conjugate to form the ATG12-ATG5-ATG16L1 complex.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of A16L1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
ATG5_MOUSE	Atg5	physical	12665549
A16L1_MOUSE	Atg16l1	physical	12665549

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of A16L1_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-289, AND MASSSPECTROMETRY.	17242355 [Abstract]

show