A16L1_MOUSE - dbPTM
A16L1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID A16L1_MOUSE
UniProt AC Q8C0J2
Protein Name Autophagy-related protein 16-1
Gene Name Atg16l1
Organism Mus musculus (Mouse).
Sequence Length 607
Subcellular Localization Cytoplasm. Preautophagosomal structure membrane
Peripheral membrane protein . Recruited to omegasomes membranes by WIPI2. Omegasomes are endoplasmic reticulum connected strutures at the origin of preautophagosomal structures. Localized to preautoph
Protein Description Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane. [PubMed: 18849966]
Protein Sequence MSSGLRAADFPRWKRHIAEELRRRDRLQRQAFEEIILQYTKLLEKSDLHSVLTQKLQAEKHDMPNRHEISPGHDGAWNDSQLQEMAQLRIKHQEELTELHKKRGELAQLVIDLNNQMQQKDKEIQMNEAKISEYLQTISDLETNCLDLRTKLQDLEVANQTLKDEYDALQITFTALEEKLRKTTEENQELVTRWMAEKAQEANRLNAENEKDSRRRQARLQKELAEAAKEPLPVEQDDDIEVIVDETSDHTEETSPVRAVSRAATKRLSQPAGGLLDSITNIFGRRSVSSIPVPQDIMDTHPASGKDVRVPTTASYVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEAFGDKCEFKGSLSGSNAGITSIEFDSAGAYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFAGSSCNDIVCTEQCVMSGHFDKKIRFWDIRSESVVREMELLGKITALDLNPERTELLSCSRDDLLKVIDLRTNAVKQTFSAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYVWSVLTGKVEKVLSKQHSSSINAVAWAPSGLHVVSVDKGSRAVLWAQP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
70PhosphorylationMPNRHEISPGHDGAW
CCCCCCCCCCCCCCC
23.1126370283
132PhosphorylationQMNEAKISEYLQTIS
HHCHHHHHHHHHHHH
21.3428059163
139PhosphorylationSEYLQTISDLETNCL
HHHHHHHHHHHHHHH
39.26-
211AcetylationRLNAENEKDSRRRQA
HCCCCCHHHHHHHHH
73.006569509
247PhosphorylationIEVIVDETSDHTEET
CEEEEECCCCCCCCC
34.6829899451
248PhosphorylationEVIVDETSDHTEETS
EEEEECCCCCCCCCC
25.9123984901
251PhosphorylationVDETSDHTEETSPVR
EECCCCCCCCCCHHH
40.2729899451
254PhosphorylationTSDHTEETSPVRAVS
CCCCCCCCCHHHHHH
31.9029899451
255PhosphorylationSDHTEETSPVRAVSR
CCCCCCCCHHHHHHH
25.3619060867
265 (in isoform 5)Phosphorylation-18.7326643407
265 (in isoform 2)Phosphorylation-18.7326643407
268 (in isoform 5)Phosphorylation-6.2526643407
268 (in isoform 2)Phosphorylation-6.2526643407
269PhosphorylationRAATKRLSQPAGGLL
HHHHHHHCCCCCHHH
37.8426824392
270 (in isoform 5)Phosphorylation-36.1326643407
270 (in isoform 2)Phosphorylation-36.1326643407
271 (in isoform 5)Phosphorylation-29.5126643407
271 (in isoform 2)Phosphorylation-29.5126643407
278PhosphorylationPAGGLLDSITNIFGR
CCCHHHHHHHHHHCC
31.1426824392
280PhosphorylationGGLLDSITNIFGRRS
CHHHHHHHHHHCCCC
26.6423984901
287PhosphorylationTNIFGRRSVSSIPVP
HHHHCCCCCCCCCCC
25.6225521595
289PhosphorylationIFGRRSVSSIPVPQD
HHCCCCCCCCCCCCC
24.6427742792
290PhosphorylationFGRRSVSSIPVPQDI
HCCCCCCCCCCCCCH
28.8427742792
300PhosphorylationVPQDIMDTHPASGKD
CCCCHHHCCCCCCCC
16.6325619855
304PhosphorylationIMDTHPASGKDVRVP
HHHCCCCCCCCCCCC
51.3225619855
339PhosphorylationPGSRLLATGGMDRRV
CCCCEECCCCCCHHH
33.9525338131
361PhosphorylationDKCEFKGSLSGSNAG
CCCEEECCCCCCCCC
21.69-
371PhosphorylationGSNAGITSIEFDSAG
CCCCCCEEEEECCHH
20.42-
445PhosphorylationRSKVCIKTVFAGSSC
CCCEEEEEECCCCCC
10.8420469934
450PhosphorylationIKTVFAGSSCNDIVC
EEEECCCCCCCCEEE
28.4320469934
451PhosphorylationKTVFAGSSCNDIVCT
EEECCCCCCCCEEEC
18.9320469934
458PhosphorylationSCNDIVCTEQCVMSG
CCCCEEECCHHHHCC
20.4220469934
464PhosphorylationCTEQCVMSGHFDKKI
ECCHHHHCCCCCCEE
14.5520469934
513UbiquitinationCSRDDLLKVIDLRTN
ECHHHHHHHHHHCCH
44.43-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of A16L1_MOUSE !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
139SPhosphorylation

-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of A16L1_MOUSE !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ATG5_MOUSEAtg5physical
12665549
A16L1_MOUSEAtg16l1physical
12665549

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of A16L1_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-289, AND MASSSPECTROMETRY.

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