UniProt ID | A16L1_MOUSE | |
---|---|---|
UniProt AC | Q8C0J2 | |
Protein Name | Autophagy-related protein 16-1 | |
Gene Name | Atg16l1 | |
Organism | Mus musculus (Mouse). | |
Sequence Length | 607 | |
Subcellular Localization |
Cytoplasm. Preautophagosomal structure membrane Peripheral membrane protein . Recruited to omegasomes membranes by WIPI2. Omegasomes are endoplasmic reticulum connected strutures at the origin of preautophagosomal structures. Localized to preautoph |
|
Protein Description | Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane. [PubMed: 18849966] | |
Protein Sequence | MSSGLRAADFPRWKRHIAEELRRRDRLQRQAFEEIILQYTKLLEKSDLHSVLTQKLQAEKHDMPNRHEISPGHDGAWNDSQLQEMAQLRIKHQEELTELHKKRGELAQLVIDLNNQMQQKDKEIQMNEAKISEYLQTISDLETNCLDLRTKLQDLEVANQTLKDEYDALQITFTALEEKLRKTTEENQELVTRWMAEKAQEANRLNAENEKDSRRRQARLQKELAEAAKEPLPVEQDDDIEVIVDETSDHTEETSPVRAVSRAATKRLSQPAGGLLDSITNIFGRRSVSSIPVPQDIMDTHPASGKDVRVPTTASYVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEAFGDKCEFKGSLSGSNAGITSIEFDSAGAYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFAGSSCNDIVCTEQCVMSGHFDKKIRFWDIRSESVVREMELLGKITALDLNPERTELLSCSRDDLLKVIDLRTNAVKQTFSAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYVWSVLTGKVEKVLSKQHSSSINAVAWAPSGLHVVSVDKGSRAVLWAQP | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
|
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
70 | Phosphorylation | MPNRHEISPGHDGAW CCCCCCCCCCCCCCC | 23.11 | 26370283 | |
132 | Phosphorylation | QMNEAKISEYLQTIS HHCHHHHHHHHHHHH | 21.34 | 28059163 | |
139 | Phosphorylation | SEYLQTISDLETNCL HHHHHHHHHHHHHHH | 39.26 | - | |
211 | Acetylation | RLNAENEKDSRRRQA HCCCCCHHHHHHHHH | 73.00 | 6569509 | |
247 | Phosphorylation | IEVIVDETSDHTEET CEEEEECCCCCCCCC | 34.68 | 29899451 | |
248 | Phosphorylation | EVIVDETSDHTEETS EEEEECCCCCCCCCC | 25.91 | 23984901 | |
251 | Phosphorylation | VDETSDHTEETSPVR EECCCCCCCCCCHHH | 40.27 | 29899451 | |
254 | Phosphorylation | TSDHTEETSPVRAVS CCCCCCCCCHHHHHH | 31.90 | 29899451 | |
255 | Phosphorylation | SDHTEETSPVRAVSR CCCCCCCCHHHHHHH | 25.36 | 19060867 | |
265 (in isoform 5) | Phosphorylation | - | 18.73 | 26643407 | |
265 (in isoform 2) | Phosphorylation | - | 18.73 | 26643407 | |
268 (in isoform 5) | Phosphorylation | - | 6.25 | 26643407 | |
268 (in isoform 2) | Phosphorylation | - | 6.25 | 26643407 | |
269 | Phosphorylation | RAATKRLSQPAGGLL HHHHHHHCCCCCHHH | 37.84 | 26824392 | |
270 (in isoform 5) | Phosphorylation | - | 36.13 | 26643407 | |
270 (in isoform 2) | Phosphorylation | - | 36.13 | 26643407 | |
271 (in isoform 5) | Phosphorylation | - | 29.51 | 26643407 | |
271 (in isoform 2) | Phosphorylation | - | 29.51 | 26643407 | |
278 | Phosphorylation | PAGGLLDSITNIFGR CCCHHHHHHHHHHCC | 31.14 | 26824392 | |
280 | Phosphorylation | GGLLDSITNIFGRRS CHHHHHHHHHHCCCC | 26.64 | 23984901 | |
287 | Phosphorylation | TNIFGRRSVSSIPVP HHHHCCCCCCCCCCC | 25.62 | 25521595 | |
289 | Phosphorylation | IFGRRSVSSIPVPQD HHCCCCCCCCCCCCC | 24.64 | 27742792 | |
290 | Phosphorylation | FGRRSVSSIPVPQDI HCCCCCCCCCCCCCH | 28.84 | 27742792 | |
300 | Phosphorylation | VPQDIMDTHPASGKD CCCCHHHCCCCCCCC | 16.63 | 25619855 | |
304 | Phosphorylation | IMDTHPASGKDVRVP HHHCCCCCCCCCCCC | 51.32 | 25619855 | |
339 | Phosphorylation | PGSRLLATGGMDRRV CCCCEECCCCCCHHH | 33.95 | 25338131 | |
361 | Phosphorylation | DKCEFKGSLSGSNAG CCCEEECCCCCCCCC | 21.69 | - | |
371 | Phosphorylation | GSNAGITSIEFDSAG CCCCCCEEEEECCHH | 20.42 | - | |
445 | Phosphorylation | RSKVCIKTVFAGSSC CCCEEEEEECCCCCC | 10.84 | 20469934 | |
450 | Phosphorylation | IKTVFAGSSCNDIVC EEEECCCCCCCCEEE | 28.43 | 20469934 | |
451 | Phosphorylation | KTVFAGSSCNDIVCT EEECCCCCCCCEEEC | 18.93 | 20469934 | |
458 | Phosphorylation | SCNDIVCTEQCVMSG CCCCEEECCHHHHCC | 20.42 | 20469934 | |
464 | Phosphorylation | CTEQCVMSGHFDKKI ECCHHHHCCCCCCEE | 14.55 | 20469934 | |
513 | Ubiquitination | CSRDDLLKVIDLRTN ECHHHHHHHHHHCCH | 44.43 | - |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of A16L1_MOUSE !! |
Modified Location | Modified Residue | Modification | Function | Reference |
---|---|---|---|---|
139 | S | Phosphorylation |
| - |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of A16L1_MOUSE !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
ATG5_MOUSE | Atg5 | physical | 12665549 | |
A16L1_MOUSE | Atg16l1 | physical | 12665549 |
Kegg Drug | ||||||
---|---|---|---|---|---|---|
DrugBank | ||||||
There are no disease associations of PTM sites. |
loading...