ARRS_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARRS_HUMAN
• UniProt AC: P10523
• Protein Name: S-arrestin
• Gene Name: SAG
• Organism: Homo sapiens (Human).
• Sequence Length: 405
• Subcellular Localization: Cell projection, cilium, photoreceptor outer segment . Membrane ; Peripheral membrane protein . Highly expressed in photoreceptor outer segments in light-exposed retina. Evenly distributed throughout rod photoreceptor cells in dark-adapted retina (By
• Protein Description: Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G-proteins by competing with G-proteins for the same binding site on RHO (By similarity). May play a role in preventing light-dependent degeneration of retinal photoreceptor cells. [PubMed: 9565049]
• Protein Sequence: MAASGKTSKSEPNHVIFKKISRDKSVTIYLGNRDYIDHVSQVQPVDGVVLVDPDLVKGKKVYVTLTCAFRYGQEDIDVIGLTFRRDLYFSRVQVYPPVGAASTPTKLQESLLKKLGSNTYPFLLTFPDYLPCSVMLQPAPQDSGKSCGVDFEVKAFATDSTDAEEDKIPKKSSVRLLIRKVQHAPLEMGPQPRAEAAWQFFMSDKPLHLAVSLNKEIYFHGEPIPVTVTVTNNTEKTVKKIKAFVEQVANVVLYSSDYYVKPVAMEEAQEKVPPNSTLTKTLTLLPLLANNRERRGIALDGKIKHEDTNLASSTIIKEGIDRTVLGILVSYQIKVKLTVSGFLGELTSSEVATEVPFRLMHPQPEDPAKESYQDANLVFEEFARHNLKDAGEAEEGKRDKNDVDE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Acetylation	AASGKTSKSEPNHVI CCCCCCCCCCCCCEE	65.16	155313
29	Phosphorylation	RDKSVTIYLGNRDYI CCCCEEEEECCHHHC	10.13	-
62	Phosphorylation	LVKGKKVYVTLTCAF HCCCCEEEEEEEEEH	9.15	-
64	Phosphorylation	KGKKVYVTLTCAFRY CCCEEEEEEEEEHHH	9.92	-
66	Phosphorylation	KKVYVTLTCAFRYGQ CEEEEEEEEEHHHCC	7.76	-
110	Phosphorylation	TPTKLQESLLKKLGS CCHHHHHHHHHHHCC	26.49	24719451
120	Phosphorylation	KKLGSNTYPFLLTFP HHHCCCCCCEEEECC	9.02	-
129	Phosphorylation	FLLTFPDYLPCSVML EEEECCCCCCCEEEE	16.87	-
143	Phosphorylation	LQPAPQDSGKSCGVD EEECCCCCCCCCCCC	42.76	26471730
234	Phosphorylation	TVTVTNNTEKTVKKI EEEEECCCHHHHHHH	40.71	-
254	Phosphorylation	QVANVVLYSSDYYVK HHHHHHEECCCCEEC	8.43	22817900
258	Phosphorylation	VVLYSSDYYVKPVAM HHEECCCCEECCCCH	16.47	22817900
348	Phosphorylation	GFLGELTSSEVATEV HHHCCCCCCCEECCC	36.81	22817900
349	Phosphorylation	FLGELTSSEVATEVP HHCCCCCCCEECCCC	30.75	22817900
353	Phosphorylation	LTSSEVATEVPFRLM CCCCCEECCCCCCCC	42.57	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	NEDD4	P46934	PMID:25216516

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARRS_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARRS_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
OPSD_HUMAN	RHO	physical	1917988
ARRS_HUMAN	SAG	physical	21288033

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 258100: Night blindness, congenital stationary, Oguchi type 1 (CSNBO1)
• 613758: Retinitis pigmentosa 47 (RP47)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.