OPSD_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: OPSD_HUMAN
• UniProt AC: P08100
• Protein Name: Rhodopsin
• Gene Name: RHO
• Organism: Homo sapiens (Human).
• Sequence Length: 348
• Subcellular Localization: Membrane ; Multi-pass membrane protein . Cell projection, cilium, photoreceptor outer segment . Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to disk membranes in the rod outer segment (OS) photosensory c
• Protein Description: Photoreceptor required for image-forming vision at low light intensity. [PubMed: 8107847]
• Protein Sequence: MNGTEGPNFYVPFSNATGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVLGGFTSTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLAGWSRYIPEGLQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIIIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQGSNFGPIFMTIPAFFAKSAAIYNPVIYIMMNKQFRNCMLTTICCGKNPLGDDEASATVSKTETSQVAPA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MNGTEGPN -------CCCCCCCC	10.61	-
2	N-linked_Glycosylation	------MNGTEGPNF ------CCCCCCCCE	67.12	UniProtKB CARBOHYD
15	N-linked_Glycosylation	NFYVPFSNATGVVRS CEEECCCCCCCCCCC	41.73	28753425
136	Phosphorylation	VVLAIERYVVVCKPM HHHHHHHEEEEEEEC	5.70	-
296	Other	TIPAFFAKSAAIYNP CHHHHHHHHHHHHCH	35.16	-
301	Phosphorylation	FAKSAAIYNPVIYIM HHHHHHHHCHHHHHH	14.53	-
306	Phosphorylation	AIYNPVIYIMMNKQF HHHCHHHHHHCCHHH	5.29	28331001
322	S-palmitoylation	NCMLTTICCGKNPLG CCEEEEECCCCCCCC	2.05	30914787
323	S-palmitoylation	CMLTTICCGKNPLGD CEEEEECCCCCCCCC	8.43	30914787
334	Dephosphorylation	PLGDDEASATVSKTE CCCCCCHHCCCCCCC	23.56	11498053
334	Phosphorylation	PLGDDEASATVSKTE CCCCCCHHCCCCCCC	23.56	11910029
336	Phosphorylation	GDDEASATVSKTETS CCCCHHCCCCCCCCC	23.87	28753425
338	Phosphorylation	DEASATVSKTETSQV CCHHCCCCCCCCCCC	29.52	11910029
338	Dephosphorylation	DEASATVSKTETSQV CCHHCCCCCCCCCCC	29.52	8617805
340	Phosphorylation	ASATVSKTETSQVAP HHCCCCCCCCCCCCC	36.67	11910029
342	Phosphorylation	ATVSKTETSQVAPA- CCCCCCCCCCCCCC-	29.68	-
343	Phosphorylation	TVSKTETSQVAPA-- CCCCCCCCCCCCC--	19.20	11910029
343	Dephosphorylation	TVSKTETSQVAPA-- CCCCCCCCCCCCC--	19.20	8617805

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
334	S	Phosphorylation	Kinase	GRK1	Q15835	PhosphoELM
338	S	Phosphorylation	Kinase	GRK1	Q15835	PhosphoELM
343	S	Phosphorylation	Kinase	GRK1	Q15835	PhosphoELM
-	K	Ubiquitination	E3 ubiquitin ligase	UBR1	Q8IWV7	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of OPSD_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of OPSD_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
OPSD_HUMAN	RHO	physical	15509574
DNJB2_HUMAN	DNAJB2	physical	12754272
HSP74_HUMAN	HSPA4	physical	12754272

Drug and Disease Associations

• Kegg Disease
• H00527: Retinitis pigmentosa (RP)
• H00787: Congenital stationary night blindness (CSNB), including: CSNB type 1 (CSNB1); CSNB type 2 (CSNB2); C
• H00825: Familial flecked retina syndrome, including: Doyne honeycomb degeneration of retina (DHRD); Basal la
• OMIM Disease
• 613731: Retinitis pigmentosa 4 (RP4)
• 610445: Night blindness, congenital stationary, autosomal dominant 1 (CSNBAD1)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.