DRD4_HUMAN - dbPTM
DRD4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DRD4_HUMAN
UniProt AC P21917
Protein Name D(4) dopamine receptor
Gene Name DRD4
Organism Homo sapiens (Human).
Sequence Length 467
Subcellular Localization Cell membrane
Multi-pass membrane protein .
Protein Description Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Activated by dopamine, but also by epinephrine and norepinephrine, and by numerous synthetic agonists and drugs. [PubMed: 9003072]
Protein Sequence MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPGLPPDPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPRGPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3N-linked_Glycosylation-----MGNRSTADAD
-----CCCCCCCCCC		33.17UniProtKB CARBOHYD
6Phosphorylation--MGNRSTADADGLL
--CCCCCCCCCCCCC		25.8922210691
27PhosphorylationAGASAGASAGLAGQG
CCCCCCHHHCCCHHH		23.1922210691
63MethylationCVSVATERALQTPTN
EEEHHHHHHHCCCCC		35.92-
67PhosphorylationATERALQTPTNSFIV
HHHHHHCCCCCHHHH		32.6924248375
69PhosphorylationERALQTPTNSFIVSL
HHHHCCCCCHHHHHH		47.0524248375
75PhosphorylationPTNSFIVSLAAADLL
CCCHHHHHHHHHHHH		13.8924248375
93PhosphorylationLVLPLFVYSEVQGGA
HHHHHHHHHHHCCCC		7.5624248375
94PhosphorylationVLPLFVYSEVQGGAW
HHHHHHHHHHCCCCH		26.4524248375
104PhosphorylationQGGAWLLSPRLCDAL
CCCCHHHCHHHHHHH		13.0524719451
159PhosphorylationQLLLIGATWLLSAAV
HHHHHHHHHHHHHHH		16.07-
163PhosphorylationIGATWLLSAAVAAPV
HHHHHHHHHHHHHHH		16.41-
239PhosphorylationGRAPRRPSGPGPPSP
CCCCCCCCCCCCCCC		56.6719932171
245PhosphorylationPSGPGPPSPTPPAPR
CCCCCCCCCCCCCCC		44.5319932171
373PhosphorylationAAALPPQTPPQTRRR
HHCCCCCCCCCCHHH		42.5929978859
377PhosphorylationPPQTPPQTRRRRRAK
CCCCCCCCHHHHHHH		31.7329978859
419S-palmitoylationVVHITQALCPACSVP
HHHHHHHHCHHHCCC		2.3027659709
467S-palmitoylationRKALRACC-------
HHHHHHHC-------		6.4527659709
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseKLHL12Q53G59
PMID:20100572
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DRD4_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DRD4_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CLIC6_HUMANCLIC6physical
14499480
KCNJ3_HUMANKCNJ3physical
12297500
KCNJ9_HUMANKCNJ9physical
12297500
KCNJ5_HUMANKCNJ5physical
12297500
GRB2_HUMANGRB2physical
9843378
NCK1_HUMANNCK1physical
9843378
ARRB2_HUMANARRB2physical
20100572
CHIP_HUMANSTUB1physical
20974815
KLH12_HUMANKLHL12physical
18303015
KLH12_HUMANKLHL12physical
26717573
CUL3_HUMANCUL3physical
26717573
KLH12_HUMANKLHL12physical
27155323
ARRB2_HUMANARRB2physical
27155323
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D00059 Levodopa (JP16/USP/INN); Dopar (TN)
D00283 Clozapine (JAN/USP/INN); Clozaril (TN)
D00454 Olanzapine (JAN/USAN/INN); Zyprexa (TN)
D00458 Quetiapine fumarate (JP16/USAN); Seroquel (TN)
D00559 Pramipexole hydrochloride hydrate (JAN); Pramipexole hydrochloride (USAN); Mirapex (TN)
D00633 Dopamine hydrochloride (JP16/USP); Actopamin (TN); Intropin (TN)
D01468 Nemonapride (JAN/INN); Emilace (TN)
D02656 Fananserin (USAN/INN)
D02676 Oxiperomide (USAN/INN)
D03891 Dopexamine (USAN/INN)
D05575 Pramipexole (USAN/INN)
D05891 Sonepiprazole mesylate (USAN)
D06623 Olanzapine pamoate (USAN); Olanzapine pamoate monohydrate
D07870 Dopamine (INN); Medopa (TN)
D08456 Quetiapine (INN); Norsic (TN)
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DRD4_HUMAN

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Related Literatures of Post-Translational Modification

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