EDNRA_HUMAN - dbPTM
EDNRA_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID EDNRA_HUMAN
UniProt AC P25101
Protein Name Endothelin-1 receptor {ECO:0000305}
Gene Name EDNRA {ECO:0000312|HGNC:HGNC:3179}
Organism Homo sapiens (Human).
Sequence Length 427
Subcellular Localization Cell membrane
Multi-pass membrane protein.
Protein Description Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3..
Protein Sequence METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRSSHKDSMN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
29N-linked_GlycosylationNPERYSTNLSNHVDD
CHHHHCCCCCCCCCC		35.22UniProtKB CARBOHYD
62N-linked_GlycosylationTNLVLPSNGSMHNYC
CCEECCCCCCCCCCC		44.62UniProtKB CARBOHYD
167PhosphorylationLFPFLQKSSVGITVL
HHHHHCCCCCCCHHH		19.8022210691
184PhosphorylationCALSVDRYRAVASWS
HHCCCHHHHHHHHHH		9.8422817900
244PhosphorylationKTCMLNATSKFMEFY
CEEEHHCCHHHHHHH		31.2325072903
245PhosphorylationTCMLNATSKFMEFYQ
EEEHHCCHHHHHHHH		22.8325072903
251PhosphorylationTSKFMEFYQDVKDWW
CHHHHHHHHHHHHHH		7.1825072903
263PhosphorylationDWWLFGFYFCMPLVC
HHHHHHHHHHHHHHH		9.03-
275PhosphorylationLVCTAIFYTLMTCEM
HHHHHHHHHHHHHHH		7.89-
289PhosphorylationMLNRRNGSLRIALSE
HHHHCCCCHHHHHHH		20.3022817900
295PhosphorylationGSLRIALSEHLKQRR
CCHHHHHHHHHHHHH		17.5929396449
331PhosphorylationLSRILKKTVYNEMDK
HHHHHHHHHHHHCCC		27.0029496907
333PhosphorylationRILKKTVYNEMDKNR
HHHHHHHHHHCCCCH		15.6129496907
338AcetylationTVYNEMDKNRCELLS
HHHHHCCCCHHHHHH		45.017708215
382PhosphorylationKFKNCFQSCLCCCCY
HHHHHHHHHHHHHHH		6.7122817900
383S-palmitoylationFKNCFQSCLCCCCYQ
HHHHHHHHHHHHHHC		2.0410074362
385S-palmitoylationNCFQSCLCCCCYQSK
HHHHHHHHHHHHCCC		1.6410074362
386S-palmitoylationCFQSCLCCCCYQSKS
HHHHHHHHHHHCCCC		0.8610074362
387S-palmitoylationFQSCLCCCCYQSKSL
HHHHHHHHHHCCCCC		2.0610074362
388S-palmitoylationQSCLCCCCYQSKSLM
HHHHHHHHHCCCCCE		1.8510074362
389PhosphorylationSCLCCCCYQSKSLMT
HHHHHHHHCCCCCEE		11.2522817900
391PhosphorylationLCCCCYQSKSLMTSV
HHHHHHCCCCCEEEC		9.5722817900
393PhosphorylationCCCYQSKSLMTSVPM
HHHHCCCCCEEECCC		28.7222817900
396PhosphorylationYQSKSLMTSVPMNGT
HCCCCCEEECCCCCC		31.6830576142
397PhosphorylationQSKSLMTSVPMNGTS
CCCCCEEECCCCCCE		15.4022817900
403PhosphorylationTSVPMNGTSIQWKNH
EECCCCCCEEEECCC		20.0430576142
404PhosphorylationSVPMNGTSIQWKNHD
ECCCCCCEEEECCCC		17.7428857561
417PhosphorylationHDQNNHNTDRSSHKD
CCCCCCCCCCCCCCC		25.8222817900
420PhosphorylationNNHNTDRSSHKDSMN
CCCCCCCCCCCCCCC		39.3422817900
421PhosphorylationNHNTDRSSHKDSMN-
CCCCCCCCCCCCCC-		35.1422817900
425PhosphorylationDRSSHKDSMN-----
CCCCCCCCCC-----		25.6514636059
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
391SPhosphorylationKinaseGRK2P25098
PSP
393SPhosphorylationKinaseGRK2P25098
PSP
396TPhosphorylationKinaseGRK2P25098
PSP
397SPhosphorylationKinaseGRK2P25098
PSP
403TPhosphorylationKinaseGRK2P25098
PSP
404SPhosphorylationKinaseGRK2P25098
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of EDNRA_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of EDNRA_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
KAT5_HUMANKAT5physical
11262386
HDAC7_HUMANHDAC7physical
11262386
CSN5_HUMANCOPS5physical
20034471
VPS11_HUMANVPS11physical
9645692
EDN1_HUMANEDN1physical
7509919
ARL5B_HUMANARL5Bphysical
26186194
SNG2_HUMANSYNGR2physical
26186194
NU1M_HUMANND1physical
26186194
EBP_HUMANEBPphysical
26186194
MTX1_HUMANMTX1physical
26186194
LMBR1_HUMANLMBR1physical
26186194
COX1_HUMANCOX1physical
26186194
PXMP2_HUMANPXMP2physical
26186194
MCL1_HUMANMCL1physical
26186194
VKORL_HUMANVKORC1L1physical
26186194
B2L11_HUMANBCL2L11physical
26186194
B2L11_HUMANBCL2L11physical
28514442
MCL1_HUMANMCL1physical
28514442
MTX1_HUMANMTX1physical
28514442
ARL5B_HUMANARL5Bphysical
28514442
LMBR1_HUMANLMBR1physical
28514442
NU1M_HUMANND1physical
28514442
EBP_HUMANEBPphysical
28514442
SNG2_HUMANSYNGR2physical
28514442
COX1_HUMANCOX1physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
616367Mandibulofacial dysostosis with alopecia (MFDA)
Kegg Drug
D01227 Bosentan hydrate (JAN); Bosentan (USAN); Tracleer (TN)
D03009 Atrasentan hydrochloride (USAN)
D03953 Edonentan (USAN); Edonentan monohydrate
D07077 Ambrisentan (JAN/INN); Letairis (TN); Volibris (TN)
D07171 Sitaxentan (USAN/INN)
D07538 Bosentan (INN)
D07682 Clazosentan sodium (JAN)
D07741 Zibotentan (JAN/USAN/INN)
D08517 Sitaxentan sodium (USAN); Thelin (TN)
D10135 Macitentan (USAN)
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of EDNRA_HUMAN

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