dbPTM

EDN1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	EDN1_HUMAN
UniProt AC	P05305
Protein Name	Endothelin-1
Gene Name	EDN1
Organism	Homo sapiens (Human).
Sequence Length	212
Subcellular Localization	Secreted.
Protein Description	Endothelins are endothelium-derived vasoconstrictor peptides..
Protein Sequence	MDYLLMIFSLLFVACQGAPETAVLGAELSAVGENGGEKPTPSPPWRLRRSKRCSCSSLMDKECVYFCHLDIIWVNTPEHVVPYGLGSPRSKRALENLLPTKATDRENRCQCASQKDKKCWNFCQAGKELRAEDIMEKDWNNHKKGKDCSKLGKKCIYQQLVRGRKIRRSSEEHLRQTRSETMRNSVKSSFHDPKLKGKPSRERYVTHNRAHW

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
87	Phosphorylation	VVPYGLGSPRSKRAL CCCCCCCCHHHHHHH	23.37	20562096
100	O-linked_Glycosylation	ALENLLPTKATDREN HHHHHCCCCCCCCCC	33.03	55828383
118	"N6,N6-dimethyllysine"	CASQKDKKCWNFCQA CCCCCCHHHHHHHHH	55.40	-
118	Methylation	CASQKDKKCWNFCQA CCCCCCHHHHHHHHH	55.40	-
127	"N6,N6-dimethyllysine"	WNFCQAGKELRAEDI HHHHHHCCCCCHHHH	57.50	-
127	Methylation	WNFCQAGKELRAEDI HHHHHHCCCCCHHHH	57.50	-
143	Ubiquitination	EKDWNNHKKGKDCSK HHCCCCCCCCCCHHH	66.40	-
144	Ubiquitination	KDWNNHKKGKDCSKL HCCCCCCCCCCHHHH	64.74	-
169	Phosphorylation	RGRKIRRSSEEHLRQ HCCCCCCCCHHHHHH	32.05	28270605
170	Phosphorylation	GRKIRRSSEEHLRQT CCCCCCCCHHHHHHH	45.23	28270605
177	Phosphorylation	SEEHLRQTRSETMRN CHHHHHHHHHHHHHH	29.72	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of EDN1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of EDN1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of EDN1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BAG6_HUMAN	BAG6	physical	16169070
CSN6_HUMAN	COPS6	physical	16169070
EDN1_HUMAN	EDN1	physical	15568807

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
612798	Question mark ears, isolated (QME)
615706	Auriculocondylar syndrome 3 (ARCND3)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of EDN1_HUMAN

Related Literatures of Post-Translational Modification