PE2R2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PE2R2_HUMAN
• UniProt AC: P43116
• Protein Name: Prostaglandin E2 receptor EP2 subtype
• Gene Name: PTGER2
• Organism: Homo sapiens (Human).
• Sequence Length: 358
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle..
• Protein Sequence: MGNASNDSQSEDCETRQWLPPGESPAISSVMFSAGVLGNLIALALLARRWRGDVGCSAGRRSSLSLFHVLVTELVFTDLLGTCLISPVVLASYARNQTLVALAPESRACTYFAFAMTFFSLATMLMLFAMALERYLSIGHPYFYQRRVSRSGGLAVLPVIYAVSLLFCSLPLLDYGQYVQYCPGTWCFIRHGRTAYLQLYATLLLLLIVSVLACNFSVILNLIRMHRRSRRSRCGPSLGSGRGGPGARRRGERVSMAEETDHLILLAIMTITFAVCSLPFTIFAYMNETSSRKEKWDLQALRFLSINSIIDPWVFAILRPPVLRLMRSVLCCRISLRTQDATQTSCSTQSDASKQADL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	N-linked_Glycosylation	-----MGNASNDSQS -----CCCCCCCCCC	38.61	UniProtKB CARBOHYD
6	N-linked_Glycosylation	--MGNASNDSQSEDC --CCCCCCCCCCCCC	51.01	UniProtKB CARBOHYD
10	Phosphorylation	NASNDSQSEDCETRQ CCCCCCCCCCCCCCC	39.08	-
15	Phosphorylation	SQSEDCETRQWLPPG CCCCCCCCCCCCCCC	34.20	-
33	Phosphorylation	AISSVMFSAGVLGNL CHHHHHHCHHHHHHH	13.15	-
57	Phosphorylation	WRGDVGCSAGRRSSL HCCCCCCCCCCCHHH	28.03	-
62	Phosphorylation	GCSAGRRSSLSLFHV CCCCCCCHHHHHHHH	33.98	-
77	Phosphorylation	LVTELVFTDLLGTCL HHHHHHHHHHHHHHH	20.47	26074081
82	Phosphorylation	VFTDLLGTCLISPVV HHHHHHHHHHHCHHH	12.24	26074081
86	Phosphorylation	LLGTCLISPVVLASY HHHHHHHCHHHHHHH	9.93	26074081
96	N-linked_Glycosylation	VLASYARNQTLVALA HHHHHHCCCCEEEEC	30.89	UniProtKB CARBOHYD
98	Phosphorylation	ASYARNQTLVALAPE HHHHCCCCEEEECCC	27.09	22468782
106	Phosphorylation	LVALAPESRACTYFA EEEECCCHHHHHHHH	24.90	22468782
194	Phosphorylation	CFIRHGRTAYLQLYA EEEECCCHHHHHHHH	25.01	-
196	Phosphorylation	IRHGRTAYLQLYATL EECCCHHHHHHHHHH	8.38	-
237	Phosphorylation	RRSRCGPSLGSGRGG CHHCCCCCCCCCCCC	30.55	29978859
240	Phosphorylation	RCGPSLGSGRGGPGA CCCCCCCCCCCCCCC	30.52	28450419
287	N-linked_Glycosylation	FTIFAYMNETSSRKE HHHHHHHCCCCCCHH	36.40	UniProtKB CARBOHYD
305	Phosphorylation	LQALRFLSINSIIDP HHHHHHHCCHHCCCH	19.60	27732954
308	Phosphorylation	LRFLSINSIIDPWVF HHHHCCHHCCCHHHH	21.17	27732954

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PE2R2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PE2R2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PE2R2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PE2R2_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.