ZFX_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZFX_HUMAN
• UniProt AC: P17010
• Protein Name: Zinc finger X-chromosomal protein
• Gene Name: ZFX
• Organism: Homo sapiens (Human).
• Sequence Length: 805
• Subcellular Localization: Nucleus.
• Protein Description: Probable transcriptional activator..
• Protein Sequence: MDEDGLELQQEPNSFFDATGADGTHMDGDQIVVEVQETVFVSDVVDSDITVHNFVPDDPDSVVIQDVIEDVVIEDVQCPDIMEEADVSETVIIPEQVLDSDVTEEVSLAHCTVPDDVLASDITSASMSMPEHVLTGDSIHVSDVGHVGHVGHVEHVVHDSVVEAEIVTDPLTTDVVSEEVLVADCASEAVIDANGIPVDQQDDDKGNCEDYLMISLDDAGKIEHDGSSGMTMDTESEIDPCKVDGTCPEVIKVYIFKADPGEDDLGGTVDIVESEPENDHGVELLDQNSSIRVPREKMVYMTVNDSQPEDEDLNVAEIADEVYMEVIVGEEDAAAAAAAAAVHEQQMDDNEIKTFMPIAWAAAYGNNSDGIENRNGTASALLHIDESAGLGRLAKQKPKKRRRPDSRQYQTAIIIGPDGHPLTVYPCMICGKKFKSRGFLKRHMKNHPEHLAKKKYRCTDCDYTTNKKISLHNHLESHKLTSKAEKAIECDECGKHFSHAGALFTHKMVHKEKGANKMHKCKFCEYETAEQGLLNRHLLAVHSKNFPHICVECGKGFRHPSELKKHMRIHTGEKPYQCQYCEYRSADSSNLKTHVKTKHSKEMPFKCDICLLTFSDTKEVQQHALIHQESKTHQCLHCDHKSSNSSDLKRHIISVHTKDYPHKCDMCDKGFHRPSELKKHVAAHKGKKMHQCRHCDFKIADPFVLSRHILSVHTKDLPFRCKRCRKGFRQQSELKKHMKTHSGRKVYQCEYCEYSTTDASGFKRHVISIHTKDYPHRCEYCKKGFRRPSEKNQHIMRHHKEVGLP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
211	Phosphorylation	DKGNCEDYLMISLDD CCCCCCEEEEEEECC	3.95	28102081
215	Phosphorylation	CEDYLMISLDDAGKI CCEEEEEEECCCCCC	16.27	28102081
252	Ubiquitination	GTCPEVIKVYIFKAD CCCCCCEEEEEEECC	33.87	-
257	Sumoylation	VIKVYIFKADPGEDD CEEEEEEECCCCCCC	42.18	-
268	Phosphorylation	GEDDLGGTVDIVESE CCCCCCCEEEEEECC	17.13	30266825
274	Phosphorylation	GTVDIVESEPENDHG CEEEEEECCCCCCCC	47.78	23401153
289	Phosphorylation	VELLDQNSSIRVPRE CEEECCCCCCCCCHH	22.85	30576142
290	Phosphorylation	ELLDQNSSIRVPREK EEECCCCCCCCCHHH	23.20	26126808
425	Phosphorylation	DGHPLTVYPCMICGK CCCCCEEEEEEECCC	5.86	-
456	Phosphorylation	EHLAKKKYRCTDCDY HHHHHCCCCCCCCCC	21.57	29449344
459	Phosphorylation	AKKKYRCTDCDYTTN HHCCCCCCCCCCCCC	30.57	29449344
463	Phosphorylation	YRCTDCDYTTNKKIS CCCCCCCCCCCCEEE	23.07	29449344
464	Phosphorylation	RCTDCDYTTNKKISL CCCCCCCCCCCEEEE	15.61	29449344
465	Phosphorylation	CTDCDYTTNKKISLH CCCCCCCCCCEEEEH	38.52	29449344
468	Sumoylation	CDYTTNKKISLHNHL CCCCCCCEEEEHHHH	39.33	-
468	Ubiquitination	CDYTTNKKISLHNHL CCCCCCCEEEEHHHH	39.33	-
468	Sumoylation	CDYTTNKKISLHNHL CCCCCCCEEEEHHHH	39.33	-
479	Ubiquitination	HNHLESHKLTSKAEK HHHHHHCCCCHHHHH	63.84	-
486 (in isoform 2)	Ubiquitination	-	60.57	21890473
543	Phosphorylation	RHLLAVHSKNFPHIC HHHHHHHCCCCCCEE	23.77	26055452
571	Phosphorylation	KKHMRIHTGEKPYQC HHHCEECCCCCCCCC	44.67	29496963
580	Phosphorylation	EKPYQCQYCEYRSAD CCCCCCCEEECCCCC	8.55	-
592	Ubiquitination	SADSSNLKTHVKTKH CCCCCCCCHHEECCC	40.61	-
593	O-linked_Glycosylation	ADSSNLKTHVKTKHS CCCCCCCHHEECCCC	34.76	30379171
597	Phosphorylation	NLKTHVKTKHSKEMP CCCHHEECCCCCCCC	32.66	26270265
600	Phosphorylation	THVKTKHSKEMPFKC HHEECCCCCCCCCCC	31.69	26270265
649	Sumoylation	SSNSSDLKRHIISVH CCCCHHHHHHEEEEE	47.09	-
649	Sumoylation	SSNSSDLKRHIISVH CCCCHHHHHHEEEEE	47.09	-
654	Phosphorylation	DLKRHIISVHTKDYP HHHHHEEEEECCCCC	13.77	20068231
657	Phosphorylation	RHIISVHTKDYPHKC HHEEEEECCCCCCCC	24.37	20068231
678	Ubiquitination	FHRPSELKKHVAAHK CCCHHHHHHHHHHHC	36.46	-
714	Phosphorylation	RHILSVHTKDLPFRC CCEEEEECCCCCHHC	24.89	18669648
715	Ubiquitination	HILSVHTKDLPFRCK CEEEEECCCCCHHCH	42.25	21890473
754	Ubiquitination	YQCEYCEYSTTDASG EEEECEECCCCCCCC	14.04	21890473
754 (in isoform 1)	Ubiquitination	-	14.04	21890473
768	Phosphorylation	GFKRHVISIHTKDYP CCCEEEEEEECCCCC	13.76	27732954
771	Phosphorylation	RHVISIHTKDYPHRC EEEEEEECCCCCCCC	24.76	30576142
789	Phosphorylation	KKGFRRPSEKNQHIM CCCCCCCCHHHHHHH	60.43	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZFX_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZFX_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZFX_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ZFX_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-274, AND MASSSPECTROMETRY.
PubMed: 19690332

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-274, AND MASSSPECTROMETRY.
PubMed: 18669648

"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-274, AND MASSSPECTROMETRY.
PubMed: 15302935