CFA53_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CFA53_HUMAN
• UniProt AC: Q96M91
• Protein Name: Cilia- and flagella-associated protein 53 {ECO:0000312|HGNC:HGNC:26530}
• Gene Name: CFAP53 {ECO:0000312|HGNC:HGNC:26530}
• Organism: Homo sapiens (Human).
• Sequence Length: 514
• Subcellular Localization: Cell projection, cilium .
• Protein Description: May play a role in the beating of primary cilia and thereby be involved in the establishment of organ laterality during embryogenesis..
• Protein Sequence: MYSQRFGTVQREVKGPTPKVVIVRSKPPKGQGAEHHLERIRRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQEVLSTHQVLPQNIHPMRKACPSKLPP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
112	Phosphorylation	LALEENEYFTEMQLK HHHHHCHHHHHHHHH		19835603
135	Acetylation	DRMREKTKLLKEKNE HHHHHHHHHHHHHCH		20167786
138	Acetylation	REKTKLLKEKNEKER HHHHHHHHHHCHHHH		20167786
194	Acetylation	NEELSRQKLVEEQMF CHHHHHHHHHHHHHH		7674263
284	Phosphorylation	KQKAKQETRTILQKA HHHHHHHHHHHHHHH		23917254
286	O-linked_Glycosylation	KAKQETRTILQKALQ HHHHHHHHHHHHHHH		30379171
286	Phosphorylation	KAKQETRTILQKALQ HHHHHHHHHHHHHHH		23917254
312	Acetylation	DEQDLNMKLVQRALQ CHHHHHHHHHHHHHH		25038526
427	Acetylation	KHINESLKELNCEEK HHHHHHHHHCCHHHH		25038526
434	Acetylation	KELNCEEKENFARRQ HHCCHHHHHHHHHHH		25038526
486	Acetylation	ANKMCLDKVQEVLST HHHHHHHHHHHHHHH		25038526

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CFA53_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CFA53_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CFA53_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 614779: Heterotaxy, visceral, 6, autosomal (HTX6)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.