PLCB2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLCB2_RAT
• UniProt AC: O89040
• Protein Name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
• Gene Name: Plcb2 {ECO:0000250|UniProtKB:Q00722}
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 1183
• Protein Description: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This protein may be involved in the transduction of bitter taste stimuli..
• Protein Sequence: MSLLNPVLLPPKVKAYLSQGERFIKWDDETSIASPVILRVDPKGYYLYWTHQSKEMEFLDVTSIRDTRFGKFAKIPKSQKLREVFNMDFPDNHFLLKTFTVVSGPDMVGLTFHNFVSYKENVGKDWAEDVLALAKHPMTANASRSTFLDKILVKLKMQLSPEGKIPVKNFFQMFPADRKRVEAALSACHLAKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQKQRDPRLNSLLFPPARPEQVQALIDKYEPSGINVQRGQLSPEGMVWFLCGPENSVLAHDTLRIHQDMTQPLNHYFINSSHNTYLTAGQFSGPSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDILFKEAVEAIAESAFKTSPYPVILSFENHVDSPRQQAKMAEYCRTMFGETLLTEPLENFPLKPGMPLPSPEDLRGKILIKNKKNQFSGPASPNKKPDGVSEGGFPSSVPVEEDTGWTAEDRTEVEEGEEEEEVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFISFEFSAQKNRSYLVSSFTELKAYELLSKASMQFVDYNKRQMSRVYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEFMRRQDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKLSPTANSINPVWKEEPFIFEKILVPELASLRIAVMEEGGKFIGHRIIPINALHSGYHHLCLRSESNMPLTMPALFVFLEMKDYVPDTWADLTVALANPIKYFSAHDKKSVKLKEVTGSLPEKLFSGIPVASQSNGAPVSAGNGSTAPGTKAKEEATKEVAEPQTTSLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLAELQDPAASCKLRPGKGSRKKRIVPCEETIVVPREVLEGPDPRVQDLKDRLEQELQQQGEEQYRSVLKRKEQHVTEQIAKMMELAREKQAAELKSFKETSETDTKEMKKKLEAKRLERIQAMTKVTTDKVAQERLKREINNSHIQEVVQAVKQMTETLERHQEKLEEKQTACLEQIQAMEKQFQEKALAEYEAKMKGLEAEVKESMRACFKACFPTEAEEKPERPCEASEESCPQEPLVNKTDTQESRL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
461	Ubiquitination	LRGKILIKNKKNQFS HCCCEEEECCCCCCC	60.30	-
468	Phosphorylation	KNKKNQFSGPASPNK ECCCCCCCCCCCCCC	33.82	30181290
472	Phosphorylation	NQFSGPASPNKKPDG CCCCCCCCCCCCCCC	31.94	30181290
889	Phosphorylation	KEVAEPQTTSLEELR HHHCCCCCCCHHHHH	29.12	30181290
890	Phosphorylation	EVAEPQTTSLEELRE HHCCCCCCCHHHHHH	26.52	30181290
891	Phosphorylation	VAEPQTTSLEELREL HCCCCCCCHHHHHHH	36.85	30181290
952	Phosphorylation	KLRPGKGSRKKRIVP CCCCCCCCCCCCEEE	44.40	-
1130	Acetylation	AEYEAKMKGLEAEVK HHHHHHHHCCHHHHH	60.69	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PLCB2_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLCB2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLCB2_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of PLCB2_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.