PBX3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PBX3_HUMAN
• UniProt AC: P40426
• Protein Name: Pre-B-cell leukemia transcription factor 3
• Gene Name: PBX3
• Organism: Homo sapiens (Human).
• Sequence Length: 434
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'..
• Protein Sequence: MDDQSRMLQTLAGVNLAGHSVQGGMALPPPPHGHEGADGDGRKQDIGDILHQIMTITDQSLDEAQAKKHALNCHRMKPALFSVLCEIKEKTGLSIRGAQEEDPPDPQLMRLDNMLLAEGVSGPEKGGGSAAAAAAAAASGGSSDNSIEHSDYRAKLTQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQVSNWFGNKRIRYKKNIGKFQEEANLYAAKTAVTAAHAVAAAVQNNQTNSPTTPNSGSSGSFNLPNSGDMFMNMQSLNGDSYQGSQVGANVQSQVDTLRHVINQTGGYSDGLGGNSLYSPHNLNANGGWQDATTPSSVTSPTEGPGSVHSDTSN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
82	Phosphorylation	RMKPALFSVLCEIKE HHCHHHHHHHHHHHH	18.28	24719451
90	Ubiquitination	VLCEIKEKTGLSIRG HHHHHHHHHCCCCCC	42.78	-
121	Phosphorylation	MLLAEGVSGPEKGGG CHHHCCCCCCCCCCH	60.53	18187866
129	Phosphorylation	GPEKGGGSAAAAAAA CCCCCCHHHHHHHHH	20.29	23186163
139	Phosphorylation	AAAAAAASGGSSDNS HHHHHHHHCCCCCCC	38.67	28555341
189	Phosphorylation	MNLLREQSRTRPISP HHHHHHHHCCCCCCH	30.76	22468782
195	Phosphorylation	QSRTRPISPKEIERM HHCCCCCCHHHHHHH	32.38	24719451
197	Ubiquitination	RTRPISPKEIERMVG CCCCCCHHHHHHHHH	65.61	-
211	Phosphorylation	GIIHRKFSSIQMQLK HHHHHHHCHHHHHHH	29.57	-
212	Phosphorylation	IIHRKFSSIQMQLKQ HHHHHHCHHHHHHHH	21.70	-
307	Phosphorylation	FQEEANLYAAKTAVT HHHHHHHHHHHHHHH	12.34	25159151
427	Phosphorylation	SPTEGPGSVHSDTSN CCCCCCCCCCCCCCC	21.57	23090842
430	Phosphorylation	EGPGSVHSDTSN--- CCCCCCCCCCCC---	40.19	23090842
432	Phosphorylation	PGSVHSDTSN----- CCCCCCCCCC-----	32.93	23090842
433	Phosphorylation	GSVHSDTSN------ CCCCCCCCC------	45.60	23090842

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PBX3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PBX3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PBX3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ATRAP_HUMAN	AGTRAP	physical	16189514
ZNHI3_HUMAN	ZNHIT3	physical	20211142
ATRAP_HUMAN	AGTRAP	physical	19060904
PRAF1_HUMAN	RABAC1	physical	19060904
TPM3_HUMAN	TPM3	physical	25416956
TRAF1_HUMAN	TRAF1	physical	25416956
AR6P1_HUMAN	ARL6IP1	physical	25416956
MAGC2_HUMAN	MAGEC2	physical	25416956
TRI44_HUMAN	TRIM44	physical	25416956
ATRAP_HUMAN	AGTRAP	physical	25416956
MAL2_HUMAN	MAL2	physical	25416956
FSD2_HUMAN	FSD2	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-121, AND MASSSPECTROMETRY.
PubMed: 18187866