K2C74_HUMAN - dbPTM
K2C74_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID K2C74_HUMAN
UniProt AC Q7RTS7
Protein Name Keratin, type II cytoskeletal 74
Gene Name KRT74
Organism Homo sapiens (Human).
Sequence Length 529
Subcellular Localization
Protein Description Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable)..
Protein Sequence MSRQLNIKSSGDKGNFSVHSAVVPRKAVGSLASYCAAGRGAGAGFGSRSLYSLGGNRRISFNVAGGGVRAGGYGFRPGSGYGGGRASGFAGSMFGSVALGPACLSVCPPGGIHQVTVNKSLLAPLNVELDPEIQKVRAQEREQIKVLNDKFASFIDKVRFLEQQNQVLETKWELLQQLDLNNCKKNLEPILEGYISNLRKQLETLSGDRVRLDSELRSMRDLVEDYKKRYEVEINRRTTAENEFVVLKKDADAAYAVKVELQAKVDSLDKEIKFLKCLYDAEIAQIQTHASETSVILSMDNNRDLDLDSIIAEVRMHYEEIALKSKAEAEALYQTKIQELQLAASRHGDDLKHTRSEMVELNRLIQRIRCEIGNVKKQRASLETAIADAEQRGDNALKDAQAKLDELEGALHQAKEELARMLREYQELMSLKLALDMEIATYRKLLEGEECRMSGENPSSVSISVISSSSYSYHHPSSAGVDLGASAVAGSSGSTQSGQTKTTEARGGDLKDTQGKSTPASIPARKATR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
10PhosphorylationRQLNIKSSGDKGNFS
CCCCCCCCCCCCCCE		46.1118491316
17PhosphorylationSGDKGNFSVHSAVVP
CCCCCCCEEEEEECC		23.9527251275
20PhosphorylationKGNFSVHSAVVPRKA
CCCCEEEEEECCHHH		22.1727251275
73PhosphorylationGGVRAGGYGFRPGSG
CCCCCCCCCCCCCCC		16.5123403867
79PhosphorylationGYGFRPGSGYGGGRA
CCCCCCCCCCCCCCC		31.3723403867
81PhosphorylationGFRPGSGYGGGRASG
CCCCCCCCCCCCCCC		17.8123403867
145MethylationAQEREQIKVLNDKFA
HHHHHHHHHHHHHHH		40.1223644510
150UbiquitinationQIKVLNDKFASFIDK
HHHHHHHHHHHHHHH		41.5829967540
153PhosphorylationVLNDKFASFIDKVRF
HHHHHHHHHHHHHHH		26.3528355574
157UbiquitinationKFASFIDKVRFLEQQ
HHHHHHHHHHHHHHH		30.4121963094
157AcetylationKFASFIDKVRFLEQQ
HHHHHHHHHHHHHHH		30.417706019
196PhosphorylationPILEGYISNLRKQLE
HHHHHHHHHHHHHHH		22.7124719451
214PhosphorylationGDRVRLDSELRSMRD
CCHHHHHHHHHHHHH		43.0221406692
218PhosphorylationRLDSELRSMRDLVED
HHHHHHHHHHHHHHH		30.6923401153
226PhosphorylationMRDLVEDYKKRYEVE
HHHHHHHHHHHHEEE		12.6124719451
238PhosphorylationEVEINRRTTAENEFV
EEEEECCCCCCCEEE		27.41-
309PhosphorylationNRDLDLDSIIAEVRM
CCCCCHHHHHHHHHH		24.16-
324AcetylationHYEEIALKSKAEAEA
HHHHHHHCCHHHHHH		40.6719823699
333PhosphorylationKAEAEALYQTKIQEL
HHHHHHHHHHHHHHH		22.60-
335PhosphorylationEAEALYQTKIQELQL
HHHHHHHHHHHHHHH		19.29-
336AcetylationAEALYQTKIQELQLA
HHHHHHHHHHHHHHH		27.2019823707
354PhosphorylationHGDDLKHTRSEMVEL
CCCCCCCHHHHHHHH		34.0124719451
356PhosphorylationDDLKHTRSEMVELNR
CCCCCHHHHHHHHHH		31.0624719451
425PhosphorylationLARMLREYQELMSLK
HHHHHHHHHHHHHHH		10.8028348404
430PhosphorylationREYQELMSLKLALDM
HHHHHHHHHHHHHHH		34.67-
441PhosphorylationALDMEIATYRKLLEG
HHHHHHHHHHHHHCC		29.5328348404
444UbiquitinationMEIATYRKLLEGEEC
HHHHHHHHHHCCCCC		47.1922817900
452MethylationLLEGEECRMSGENPS
HHCCCCCCCCCCCCC		26.11-
472PhosphorylationVISSSSYSYHHPSSA
EEECCCCCCCCCCCC		21.6720860994
492PhosphorylationASAVAGSSGSTQSGQ
CCCCCCCCCCCCCCC		35.5320860994
513PhosphorylationRGGDLKDTQGKSTPA
CCCCCCCCCCCCCCC		37.3221188418
517PhosphorylationLKDTQGKSTPASIPA
CCCCCCCCCCCCCCC		46.58-
518PhosphorylationKDTQGKSTPASIPAR
CCCCCCCCCCCCCCC		26.76-
521PhosphorylationQGKSTPASIPARKAT
CCCCCCCCCCCCCCC		30.24-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of K2C74_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of K2C74_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of K2C74_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of K2C74_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
194300Woolly hair autosomal dominant (ADWH)
613981Hypotrichosis 3 (HYPT3)
614929Ectodermal dysplasia 7, hair/nail type (ECTD7)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of K2C74_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-218, AND MASSSPECTROMETRY.

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