UniProt ID | BCAR3_HUMAN | |
---|---|---|
UniProt AC | O75815 | |
Protein Name | Breast cancer anti-estrogen resistance protein 3 | |
Gene Name | BCAR3 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 825 | |
Subcellular Localization | ||
Protein Description | May act as an adapter protein and couple activated growth factor receptors to a signaling pathway that regulates the proliferation in breast cancer cells. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins.. | |
Protein Sequence | MAAGKFASLPRNMPVNHQFPLASSMDLLSSRSPLAEHRPDAYQDVSIHGTLPRKKKGPPPIRSCDDFSHMGTLPHSKSPRQNSPVTQDGIQESPWQDRHGETFTFRDPHLLDPTVEYVKFSKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPLRCLEEHYGTSPGQAREGSLTKGRPDVAKRLSLTMGGVQAREQNLPRGNLLRNKEKSGSQPACLDHMQDRRALSLKAHQSESYLPIGCKLPPQSSGVDTSPCPNSPVFRTGSEPALSPAVVRRVSSDARAGEALRGSDSQLCPKPPPKPCKVPFLKVPSSPSAWLNSEANYCELNPAFATGCGRGAKLPSCAQGSHTELLTAKQNEAPGPRNSGVNYLILDDDDRERPWEPAAAQMEKGQWDKGEFVTPLLETVSSFRPNEFESKFLPPENKPLETAMLKRAKELFTNNDPKVIAQHVLSMDCRVARILGVSEEMRRNMGVSSGLELITLPHGHQLRLDIIERHNTMAIGIAVDILGCTGTLEDRAATLSKIIQVAVELKDSMGDLYSFSALMKALEMPQITRLEKTWTALRHQYTQTAILYEKQLKPFSKLLHEGRESTCVPPNNVSVPLLMPLVTLMERQAVTFEGTDMWEKNDQSCEIMLNHLATARFMAEAADSYRMNAERILAGFQPDEEMNEICKTEFQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQAEL | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
2 | Acetylation | ------MAAGKFASL ------CCCCCCCCC | 25.56 | 22814378 | |
5 | Methylation | ---MAAGKFASLPRN ---CCCCCCCCCCCC | 32.79 | - | |
8 | Phosphorylation | MAAGKFASLPRNMPV CCCCCCCCCCCCCCC | 41.88 | 25394399 | |
29 | Phosphorylation | ASSMDLLSSRSPLAE CHHHHHHHCCCCHHH | 30.88 | 24719451 | |
30 | Phosphorylation | SSMDLLSSRSPLAEH HHHHHHHCCCCHHHH | 36.43 | 24719451 | |
32 | Phosphorylation | MDLLSSRSPLAEHRP HHHHHCCCCHHHHCC | 26.64 | 25159151 | |
42 | Phosphorylation | AEHRPDAYQDVSIHG HHHCCCCCCCCCCCC | 16.78 | 21082442 | |
46 | Phosphorylation | PDAYQDVSIHGTLPR CCCCCCCCCCCCCCC | 19.70 | 28442448 | |
50 | Phosphorylation | QDVSIHGTLPRKKKG CCCCCCCCCCCCCCC | 21.30 | 30576142 | |
55 | Acetylation | HGTLPRKKKGPPPIR CCCCCCCCCCCCCCC | 65.33 | 30587161 | |
56 | Acetylation | GTLPRKKKGPPPIRS CCCCCCCCCCCCCCC | 78.62 | 30587167 | |
63 | Phosphorylation | KGPPPIRSCDDFSHM CCCCCCCCCCCCCCC | 23.71 | 20068231 | |
68 | Phosphorylation | IRSCDDFSHMGTLPH CCCCCCCCCCCCCCC | 21.40 | 20068231 | |
72 | Phosphorylation | DDFSHMGTLPHSKSP CCCCCCCCCCCCCCC | 29.55 | 23403867 | |
76 | Phosphorylation | HMGTLPHSKSPRQNS CCCCCCCCCCCCCCC | 32.65 | 20068231 | |
78 | Phosphorylation | GTLPHSKSPRQNSPV CCCCCCCCCCCCCCC | 28.47 | 20201521 | |
83 | Phosphorylation | SKSPRQNSPVTQDGI CCCCCCCCCCCCCCC | 16.65 | 22167270 | |
86 | Phosphorylation | PRQNSPVTQDGIQES CCCCCCCCCCCCCCC | 25.07 | 22167270 | |
93 | Phosphorylation | TQDGIQESPWQDRHG CCCCCCCCCCCCCCC | 18.31 | 23403867 | |
104 | Phosphorylation | DRHGETFTFRDPHLL CCCCCEEEECCHHHC | 25.77 | - | |
114 | Phosphorylation | DPHLLDPTVEYVKFS CHHHCCCCCEEEECC | 26.15 | 28152594 | |
117 | Phosphorylation | LLDPTVEYVKFSKER HCCCCCEEEECCCHH | 12.47 | 21082442 | |
119 | Ubiquitination | DPTVEYVKFSKERHI CCCCEEEECCCHHCC | 42.91 | - | |
121 | Phosphorylation | TVEYVKFSKERHIMD CCEEEECCCHHCCCC | 28.08 | 28152594 | |
122 | Ubiquitination | VEYVKFSKERHIMDR CEEEECCCHHCCCCC | 63.00 | - | |
130 | Phosphorylation | ERHIMDRTPEKLKKE HHCCCCCCHHHHHHH | 31.38 | 17001009 | |
145 | Phosphorylation | LEEELLLSSEDLRSH HHHHHCCCCHHHHHH | 31.48 | 25072903 | |
146 | Phosphorylation | EEELLLSSEDLRSHA HHHHCCCCHHHHHHH | 34.79 | 25072903 | |
164 | Phosphorylation | GRIPRQVSENLVQRD CCCCHHHHHHHHHCC | 16.66 | 27251275 | |
179 | Phosphorylation | GDFLVRDSLSSPGNF CCEEEEECCCCCCCE | 21.42 | 23663014 | |
181 | Phosphorylation | FLVRDSLSSPGNFVL EEEEECCCCCCCEEE | 38.14 | 23663014 | |
182 | Phosphorylation | LVRDSLSSPGNFVLT EEEECCCCCCCEEEE | 41.96 | 25159151 | |
189 | Phosphorylation | SPGNFVLTCQWKNLA CCCCEEEEEEECHHH | 9.43 | 20068231 | |
204 | Phosphorylation | QHFKINRTVLRLSEA HHHCCCHHHHHHHHH | 21.28 | 30576142 | |
209 | Phosphorylation | NRTVLRLSEAYSRVQ CHHHHHHHHHHHHHH | 17.47 | 26356563 | |
212 | Phosphorylation | VLRLSEAYSRVQYQF HHHHHHHHHHHHHEE | 7.92 | 28102081 | |
213 | Phosphorylation | LRLSEAYSRVQYQFE HHHHHHHHHHHHEEE | 32.78 | 28152594 | |
242 | Phosphorylation | VGNRRPISQQSGAII ECCCCCCCCCCCCEE | 25.50 | 24114839 | |
245 | Phosphorylation | RRPISQQSGAIIFQP CCCCCCCCCCEEEEE | 23.66 | 24114839 | |
266 | Phosphorylation | LRCLEEHYGTSPGQA CHHHHHHHCCCCCCC | 25.94 | 21945579 | |
268 | Phosphorylation | CLEEHYGTSPGQARE HHHHHHCCCCCCCCC | 25.28 | 21945579 | |
269 | Phosphorylation | LEEHYGTSPGQAREG HHHHHCCCCCCCCCC | 23.75 | 21945579 | |
277 | Phosphorylation | PGQAREGSLTKGRPD CCCCCCCCCCCCCCC | 28.28 | 24719451 | |
290 | Phosphorylation | PDVAKRLSLTMGGVQ CCHHHHHCCHHCHHH | 26.31 | 30266825 | |
292 | Phosphorylation | VAKRLSLTMGGVQAR HHHHHCCHHCHHHHH | 15.47 | 23927012 | |
315 | Phosphorylation | LLRNKEKSGSQPACL CCCCCCCCCCCCCHH | 44.78 | 23403867 | |
317 | Phosphorylation | RNKEKSGSQPACLDH CCCCCCCCCCCHHHH | 39.83 | 25849741 | |
332 | Phosphorylation | MQDRRALSLKAHQSE HHHHHHHHCCCCCCC | 27.17 | 24719451 | |
334 | Methylation | DRRALSLKAHQSESY HHHHHHCCCCCCCCC | 40.21 | 24129315 | |
338 | Phosphorylation | LSLKAHQSESYLPIG HHCCCCCCCCCCCCC | 20.74 | 21945579 | |
340 | Phosphorylation | LKAHQSESYLPIGCK CCCCCCCCCCCCCCC | 36.90 | 21945579 | |
341 | Phosphorylation | KAHQSESYLPIGCKL CCCCCCCCCCCCCCC | 16.67 | 21945579 | |
352 | Phosphorylation | GCKLPPQSSGVDTSP CCCCCCCCCCCCCCC | 34.53 | 23090842 | |
353 | Phosphorylation | CKLPPQSSGVDTSPC CCCCCCCCCCCCCCC | 37.27 | 23090842 | |
357 | Phosphorylation | PQSSGVDTSPCPNSP CCCCCCCCCCCCCCC | 31.96 | 22199227 | |
358 | Phosphorylation | QSSGVDTSPCPNSPV CCCCCCCCCCCCCCC | 21.75 | 25159151 | |
363 | Phosphorylation | DTSPCPNSPVFRTGS CCCCCCCCCCCCCCC | 13.95 | 25159151 | |
368 | Phosphorylation | PNSPVFRTGSEPALS CCCCCCCCCCCCCCC | 33.33 | 30266825 | |
370 | Phosphorylation | SPVFRTGSEPALSPA CCCCCCCCCCCCCHH | 39.53 | 30266825 | |
375 | Phosphorylation | TGSEPALSPAVVRRV CCCCCCCCHHHHHHH | 16.96 | 25159151 | |
383 | Phosphorylation | PAVVRRVSSDARAGE HHHHHHHCCCCHHHH | 22.23 | 28655764 | |
395 | Phosphorylation | AGEALRGSDSQLCPK HHHHHCCCCCCCCCC | 27.88 | 28857561 | |
397 | Phosphorylation | EALRGSDSQLCPKPP HHHCCCCCCCCCCCC | 27.10 | 27794612 | |
417 | Phosphorylation | VPFLKVPSSPSAWLN CCEEECCCCHHHHHC | 58.84 | 26356563 | |
418 | Phosphorylation | PFLKVPSSPSAWLNS CEEECCCCHHHHHCC | 19.46 | 26356563 | |
420 | Phosphorylation | LKVPSSPSAWLNSEA EECCCCHHHHHCCCC | 33.74 | 26356563 | |
425 | Phosphorylation | SPSAWLNSEANYCEL CHHHHHCCCCCCEEC | 35.60 | 27259358 | |
429 | Phosphorylation | WLNSEANYCELNPAF HHCCCCCCEECCHHH | 8.37 | 27259358 | |
442 | Methylation | AFATGCGRGAKLPSC HHHCCCCCCCCCCCC | 46.07 | 24129315 | |
448 | Phosphorylation | GRGAKLPSCAQGSHT CCCCCCCCCCCCCCC | 32.30 | 27251275 | |
453 | Phosphorylation | LPSCAQGSHTELLTA CCCCCCCCCCHHEEC | 18.37 | 28857561 | |
455 | Phosphorylation | SCAQGSHTELLTAKQ CCCCCCCCHHEECCC | 29.99 | 28857561 | |
459 | Phosphorylation | GSHTELLTAKQNEAP CCCCHHEECCCCCCC | 44.42 | 24719451 | |
471 | Phosphorylation | EAPGPRNSGVNYLIL CCCCCCCCCCCEEEE | 45.45 | 25159151 | |
475 | Phosphorylation | PRNSGVNYLILDDDD CCCCCCCEEEECCCC | 7.85 | 27642862 | |
541 | Malonylation | TAMLKRAKELFTNND HHHHHHHHHHHHCCC | 60.01 | 26320211 | |
541 | Acetylation | TAMLKRAKELFTNND HHHHHHHHHHHHCCC | 60.01 | 26051181 | |
541 | Ubiquitination | TAMLKRAKELFTNND HHHHHHHHHHHHCCC | 60.01 | - | |
617 | Phosphorylation | AVDILGCTGTLEDRA HHHHHCCCCCHHHHH | 31.25 | 19690332 | |
619 | Phosphorylation | DILGCTGTLEDRAAT HHHCCCCCHHHHHHH | 14.60 | 22817900 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of BCAR3_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of BCAR3_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of BCAR3_HUMAN !! |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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Phosphorylation | |
Reference | PubMed |
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-32; SER-83; SER-290;SER-358; SER-363 AND SER-375, AND MASS SPECTROMETRY. | |
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-290, AND MASSSPECTROMETRY. | |
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-182 AND SER-375, ANDMASS SPECTROMETRY. | |
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-130, AND MASSSPECTROMETRY. | |
"An extensive survey of tyrosine phosphorylation revealing new sitesin human mammary epithelial cells."; Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A.,Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D.,Wiley H.S., Qian W.-J.; J. Proteome Res. 8:3852-3861(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-212 AND TYR-266, ANDMASS SPECTROMETRY. | |
"Multiple reaction monitoring for robust quantitative proteomicanalysis of cellular signaling networks."; Wolf-Yadlin A., Hautaniemi S., Lauffenburger D.A., White F.M.; Proc. Natl. Acad. Sci. U.S.A. 104:5860-5865(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-266, AND MASSSPECTROMETRY. |