dbPTM

BEX1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	BEX1_HUMAN
UniProt AC	Q9HBH7
Protein Name	Protein BEX1
Gene Name	BEX1
Organism	Homo sapiens (Human).
Sequence Length	125
Subcellular Localization	Nucleus. Cytoplasm. Shuttles between the cytoplasm and the nucleus..
Protein Description	Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (By similarity)..
Protein Sequence	MESKEKRAVNSLSMENANQENEEKEQVANKGEPLALPLDAGEYCVPRGNRRRFRVRQPILQYRWDMMHRLGEPQARMREENMERIGEEVRQLMEKLREKQLSHSLRAVSTDPPHHDHHDEFCLMP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
43	Phosphorylation	LPLDAGEYCVPRGNR EECCCCCCCCCCCCC	9.60	27642862
95	Ubiquitination	EVRQLMEKLREKQLS HHHHHHHHHHHHHHH	38.59	27667366
99	Ubiquitination	LMEKLREKQLSHSLR HHHHHHHHHHHHHHH	50.54	27667366
102	Phosphorylation	KLREKQLSHSLRAVS HHHHHHHHHHHHHHC	14.45	-
104	Phosphorylation	REKQLSHSLRAVSTD HHHHHHHHHHHHCCC	19.04	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of BEX1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
102	S	Phosphorylation		-
Phosphorylation of Ser-102 protects it from the proteasome (By similarity).

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of BEX1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
TEX11_HUMAN	TEX11	physical	25416956

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of BEX1_HUMAN

Related Literatures of Post-Translational Modification