HXC6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HXC6_HUMAN
• UniProt AC: P09630
• Protein Name: Homeobox protein Hox-C6
• Gene Name: HOXC6
• Organism: Homo sapiens (Human).
• Sequence Length: 235
• Subcellular Localization: Nucleus.
• Protein Description: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis..
• Protein Sequence: MNSYFTNPSLSCHLAGGQDVLPNVALNSTAYDPVRHFSTYGAAVAQNRIYSTPFYSPQENVVFSSSRGPYDYGSNSFYQEKDMLSNCRQNTLGHNTQTSIAQDFSSEQGRTAPQDQKASIQIYPWMQRMNSHSGVGYGADRRRGRQIYSRYQTLELEKEFHFNRYLTRRRRIEIANALCLTERQIKIWFQNRRMKWKKESNLTSTLSGGGGGATADSLGGKEEKREETEEEKQKE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
66	Phosphorylation	ENVVFSSSRGPYDYG CCEEEECCCCCCCCC	39.81	24719451
76 (in isoform 2)	Ubiquitination	-	27.33	21890473
76	Ubiquitination	PYDYGSNSFYQEKDM CCCCCCCCCHHHHHH	27.33	21890473
113	Ubiquitination	SEQGRTAPQDQKASI CCCCCCCCCCHHHHH	37.35	22817900
115	Ubiquitination	QGRTAPQDQKASIQI CCCCCCCCHHHHHHH	51.38	22817900
116 (in isoform 2)	Ubiquitination	-	37.66	21890473
116	Ubiquitination	GRTAPQDQKASIQIY CCCCCCCHHHHHHHH	37.66	22817900
131	Phosphorylation	PWMQRMNSHSGVGYG HHHHHHHCCCCCCCC	15.08	27251275
137	Phosphorylation	NSHSGVGYGADRRRG HCCCCCCCCCCHHHC	13.51	-
149	Phosphorylation	RRGRQIYSRYQTLEL HHCHHHHHHHHHHHH	26.58	24719451
158	Ubiquitination	YQTLELEKEFHFNRY HHHHHHHHHHHHHHH	77.60	21890473
158 (in isoform 1)	Ubiquitination	-	77.60	21890473
164	Methylation	EKEFHFNRYLTRRRR HHHHHHHHHHHHHHH	27.22	-
165	Phosphorylation	KEFHFNRYLTRRRRI HHHHHHHHHHHHHHH	17.33	-
195	Ubiquitination	WFQNRRMKWKKESNL HHHCCCCCEEEHHCC	54.79	22817900
197	Ubiquitination	QNRRMKWKKESNLTS HCCCCCEEEHHCCCC	40.94	22817900
198	Acetylation	NRRMKWKKESNLTST CCCCCEEEHHCCCCC	66.32	20167786
198	Ubiquitination	NRRMKWKKESNLTST CCCCCEEEHHCCCCC	66.32	22817900
198 (in isoform 1)	Ubiquitination	-	66.32	21890473
200	Phosphorylation	RMKWKKESNLTSTLS CCCEEEHHCCCCCCC	46.12	22210691
203	Phosphorylation	WKKESNLTSTLSGGG EEEHHCCCCCCCCCC	24.74	25954137
204	Phosphorylation	KKESNLTSTLSGGGG EEHHCCCCCCCCCCC	30.43	25954137
205	Phosphorylation	KESNLTSTLSGGGGG EHHCCCCCCCCCCCC	21.51	25954137
207	Phosphorylation	SNLTSTLSGGGGGAT HCCCCCCCCCCCCCC	35.17	22210691
214	Phosphorylation	SGGGGGATADSLGGK CCCCCCCCHHHCCCC	33.98	22210691
217	Phosphorylation	GGGATADSLGGKEEK CCCCCHHHCCCCHHH	26.84	22210691
221	Acetylation	TADSLGGKEEKREET CHHHCCCCHHHHHHH	61.98	20167786

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HXC6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HXC6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HXC6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.