DEF5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DEF5_HUMAN
• UniProt AC: Q01523
• Protein Name: Defensin-5
• Gene Name: DEFA5
• Organism: Homo sapiens (Human).
• Sequence Length: 94
• Subcellular Localization: Secreted . Cytoplasmic vesicle, secretory vesicle . Peptides HD5(20-94), HD5(23-94) and HD5(29-94) are found within tissues, HD5(20-94) being the predominant intracellular form. Peptides HD5(56-94) and HD5(63-94) are found in the extracellular milieu
• Protein Description: Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing..
• Protein Sequence: MRTIAILAAILLVALQAQAESLQERADEATTQKQSGEDNQDLAISFAGNGLSALRTSGSQARATCYCRTGRCATRESLSGVCEISGRLYRLCCR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
30	Phosphorylation	QERADEATTQKQSGE HHHHHHHHHHHHCCC	27.93	25690035

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DEF5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DEF5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DEF5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DTX1_HUMAN	DTX1	physical	21988832
RHG19_HUMAN	ARHGAP19	physical	28514442
FA35A_HUMAN	FAM35A	physical	28514442
WAPL_HUMAN	WAPAL	physical	28514442
SUSD5_HUMAN	SUSD5	physical	28514442
HSP7E_HUMAN	HSPA14	physical	28514442
CILP2_HUMAN	CILP2	physical	28514442
GLCE_HUMAN	GLCE	physical	28514442
IP6K1_HUMAN	IP6K1	physical	28514442
KAISO_HUMAN	ZBTB33	physical	28514442
C170B_HUMAN	CEP170B	physical	28514442
PYC_HUMAN	PC	physical	28514442
VIR_HUMAN	KIAA1429	physical	28514442
ZN277_HUMAN	ZNF277	physical	28514442
KLD10_HUMAN	KLHDC10	physical	28514442
T132A_HUMAN	TMEM132A	physical	28514442
TGBR3_HUMAN	TGFBR3	physical	28514442
CSTN1_HUMAN	CLSTN1	physical	28514442
XAGE3_HUMAN	XAGE3	physical	28514442
TMTC3_HUMAN	TMTC3	physical	28514442
PLXA2_HUMAN	PLXNA2	physical	28514442
HTRA1_HUMAN	HTRA1	physical	28514442
FKB14_HUMAN	FKBP14	physical	28514442
EMIL2_HUMAN	EMILIN2	physical	28514442
METRL_HUMAN	METRNL	physical	28514442
METRN_HUMAN	METRN	physical	28514442
PLXB2_HUMAN	PLXNB2	physical	28514442
GSK3B_HUMAN	GSK3B	physical	28514442
PTPRK_HUMAN	PTPRK	physical	28514442
VATD_HUMAN	ATP6V1D	physical	28514442
FRAS1_HUMAN	FRAS1	physical	28514442
SULF2_HUMAN	SULF2	physical	28514442
QSOX1_HUMAN	QSOX1	physical	28514442
C1QRF_HUMAN	C1QL1	physical	28514442
BMI1_HUMAN	BMI1	physical	28514442
LOXL2_HUMAN	LOXL2	physical	28514442
MICA_HUMAN	MICA	physical	28514442
FKBP7_HUMAN	FKBP7	physical	28514442
NRP2_HUMAN	NRP2	physical	28514442
REN3B_HUMAN	UPF3B	physical	28514442
KTU_HUMAN	DNAAF2	physical	28514442
C1QL4_HUMAN	C1QL4	physical	28514442
RL24_HUMAN	RPL24	physical	28514442
PLXA1_HUMAN	PLXNA1	physical	28514442
FREM2_HUMAN	FREM2	physical	28514442
NUD19_HUMAN	NUDT19	physical	28514442
LTBP1_HUMAN	LTBP1	physical	28514442
MCMBP_HUMAN	MCMBP	physical	28514442
RS3_HUMAN	RPS3	physical	28514442
H6ST1_HUMAN	HS6ST1	physical	28514442
EFTU_HUMAN	TUFM	physical	28514442
EPHA6_HUMAN	EPHA6	physical	28514442
GALT7_HUMAN	GALNT7	physical	28514442
DEFM_HUMAN	PDF	physical	28514442
P85A_HUMAN	PIK3R1	physical	28514442
PADC1_HUMAN	PRADC1	physical	28514442
NID1_HUMAN	NID1	physical	28514442
CD109_HUMAN	CD109	physical	28514442
RDH13_HUMAN	RDH13	physical	28514442
PK3CA_HUMAN	PIK3CA	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.