| UniProt ID | EPHA6_HUMAN | |
|---|---|---|
| UniProt AC | Q9UF33 | |
| Protein Name | Ephrin type-A receptor 6 | |
| Gene Name | EPHA6 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1036 | |
| Subcellular Localization |
Membrane Single-pass type I membrane protein. |
|
| Protein Description | Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity).. | |
| Protein Sequence | MGGCEVREFLLQFGFFLPLLTAWPGDCSHVSNNQVVLLDTTTVLGELGWKTYPLNGWDAITEMDEHNRPIHTYQVCNVMEPNQNNWLRTNWISRDAAQKIYVEMKFTLRDCNSIPWVLGTCKETFNLFYMESDESHGIKFKPNQYTKIDTIAADESFTQMDLGDRILKLNTEIREVGPIERKGFYLAFQDIGACIALVSVRVFYKKCPFTVRNLAMFPDTIPRVDSSSLVEVRGSCVKSAEERDTPKLYCGADGDWLVPLGRCICSTGYEEIEGSCHACRPGFYKAFAGNTKCSKCPPHSLTYMEATSVCQCEKGYFRAEKDPPSMACTRPPSAPRNVVFNINETALILEWSPPSDTGGRKDLTYSVICKKCGLDTSQCEDCGGGLRFIPRHTGLINNSVIVLDFVSHVNYTFEIEAMNGVSELSFSPKPFTAITVTTDQDAPSLIGVVRKDWASQNSIALSWQAPAFSNGAILDYEIKYYEKEHEQLTYSSTRSKAPSVIITGLKPATKYVFHIRVRTATGYSGYSQKFEFETGDETSDMAAEQGQILVIATAAVGGFTLLVILTLFFLITGRCQWYIKAKMKSEEKRRNHLQNGHLRFPGIKTYIDPDTYEDPSLAVHEFAKEIDPSRIRIERVIGAGEFGEVCSGRLKTPGKREIPVAIKTLKGGHMDRQRRDFLREASIMGQFDHPNIIRLEGVVTKRSFPAIGVEAFCPSFLRAGFLNSIQAPHPVPGGGSLPPRIPAGRPVMIVVEYMENGSLDSFLRKHDGHFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEAAYTTTGGKIPIRWTAPEAIAYRKFSSASDAWSYGIVMWEVMSYGERPYWEMSNQDVILSIEEGYRLPAPMGCPASLHQLMLHCWQKERNHRPKFTDIVSFLDKLIRNPSALHTLVEDILVMPESPGEVPEYPLFVTVGDWLDSIKMGQYKNNFVAAGFTTFDLISRMSIDDIRRIGVILIGHQRRIVSSIQTLRLHMMHIQEKGFHV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 4 (in isoform 3) | Phosphorylation | - | 6.85 | - | |
| 4 (in isoform 2) | Phosphorylation | - | 6.85 | - | |
| 9 (in isoform 3) | Phosphorylation | - | 6.05 | 29514088 | |
| 9 (in isoform 2) | Phosphorylation | - | 6.05 | 29514088 | |
| 12 (in isoform 3) | Phosphorylation | - | 38.27 | - | |
| 12 (in isoform 2) | Phosphorylation | - | 38.27 | - | |
| 89 | Phosphorylation | NQNNWLRTNWISRDA CCCCCCCCCCCCHHH | 27.87 | - | |
| 93 | Phosphorylation | WLRTNWISRDAAQKI CCCCCCCCHHHHHHH | 28.58 | - | |
| 107 | Phosphorylation | IYVEMKFTLRDCNSI HHEEEEEEECCCCCC | 4.97 | 24719451 | |
| 120 | Phosphorylation | SIPWVLGTCKETFNL CCCCEEEECHHHEEE | 3.39 | 21130716 | |
| 199 | Phosphorylation | GACIALVSVRVFYKK HHHHHHEEHHHHHHC | 4.76 | 24719451 | |
| 300 | Phosphorylation | CSKCPPHSLTYMEAT CCCCCCCCEEEEEEC | 3.46 | - | |
| 333 | Phosphorylation | MACTRPPSAPRNVVF CCCCCCCCCCCEEEE | 16.91 | 22468782 | |
| 343 | N-linked_Glycosylation | RNVVFNINETALILE CEEEEEECCCEEEEE | 31.49 | UniProtKB CARBOHYD | |
| 397 | N-linked_Glycosylation | PRHTGLINNSVIVLD CCCCCCCCCEEEEEE | 30.57 | UniProtKB CARBOHYD | |
| 410 | N-linked_Glycosylation | LDFVSHVNYTFEIEA EEECCCCCEEEEEEE | 16.24 | UniProtKB CARBOHYD | |
| 427 | Phosphorylation | GVSELSFSPKPFTAI CCEEEEECCCCCEEE | 46.45 | 24719451 | |
| 588 | Acetylation | AKMKSEEKRRNHLQN HHCCCHHHHHHHHCC | 48.16 | 18586043 | |
| 606 | Phosphorylation | RFPGIKTYIDPDTYE CCCCCCCEECCCCCC | 8.20 | - | |
| 612 | Phosphorylation | TYIDPDTYEDPSLAV CEECCCCCCCHHHHH | 66.59 | 27196784 | |
| 664 | Phosphorylation | EIPVAIKTLKGGHMD CCCEEEEECCCCCCH | 4.05 | - | |
| 715 | Phosphorylation | GVEAFCPSFLRAGFL CCEEECHHHHHHCCC | 3.02 | - | |
| 736 | Phosphorylation | HPVPGGGSLPPRIPA CCCCCCCCCCCCCCC | 8.39 | 24719451 | |
| 784 | Phosphorylation | GMLRGIASGMKYLSD HHHHHHHHHCHHHHH | 13.95 | 22210691 | |
| 788 | Phosphorylation | GIASGMKYLSDMGYV HHHHHCHHHHHCCCC | 2.67 | 22817900 | |
| 794 | Phosphorylation | KYLSDMGYVHRDLAA HHHHHCCCCCHHHHH | 2.18 | - | |
| 808 | Phosphorylation | ARNILVNSNLVCKVS HHCEEECCCEEEEEC | 31.15 | - | |
| 815 | Phosphorylation | SNLVCKVSDFGLSRV CCEEEEECHHCHHHH | 44.62 | - | |
| 820 | Phosphorylation | KVSDFGLSRVLEDDP EECHHCHHHHCCCCC | 41.92 | 19369195 | |
| 831 | Phosphorylation | EDDPEAAYTTTGGKI CCCCCCEEECCCCCC | 17.10 | - | |
| 850 | Phosphorylation | TAPEAIAYRKFSSAS ECCHHHHHCCCCCHH | 25.23 | - | |
| 978 | Phosphorylation | DSIKMGQYKNNFVAA HHCCCCCCCCCCEEC | 37.21 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of EPHA6_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of EPHA6_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of EPHA6_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of EPHA6_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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