METRL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: METRL_HUMAN
• UniProt AC: Q641Q3
• Protein Name: Meteorin-like protein
• Gene Name: METRNL
• Organism: Homo sapiens (Human).
• Sequence Length: 311
• Subcellular Localization: Secreted.
• Protein Description: Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures (By similarity)..
• Protein Sequence: MRGAARAAWGRAGQPWPRPPAPGPPPPPLPLLLLLLAGLLGGAGAQYSSDRCSWKGSGLTHEAHRKEVEQVYLRCAAGAVEWMYPTGALIVNLRPNTFSPARHLTVCIRSFTDSSGANIYLEKTGELRLLVPDGDGRPGRVQCFGLEQGGLFVEATPQQDIGRRTTGFQYELVRRHRASDLHELSAPCRPCSDTEVLLAVCTSDFAVRGSIQQVTHEPERQDSAIHLRVSRLYRQKSRVFEPVPEGDGHWQGRVRTLLECGVRPGHGDFLFTGHMHFGEARLGCAPRFKDFQRMYRDAQERGLNPCEVGTD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
86	Phosphorylation	AVEWMYPTGALIVNL CEEEEEECCCEEEEC	20.00	22468782
97	Phosphorylation	IVNLRPNTFSPARHL EEECCCCCCCCCCEE	28.33	22468782
215	O-linked_Glycosylation	RGSIQQVTHEPERQD HCCEEECCCCCHHHC	19.04	55826621
223	Phosphorylation	HEPERQDSAIHLRVS CCCHHHCCHHHHHHH	22.30	24719451
230	Phosphorylation	SAIHLRVSRLYRQKS CHHHHHHHHHHHCCC	15.33	24719451
233	Phosphorylation	HLRVSRLYRQKSRVF HHHHHHHHHCCCCCE	15.19	24719451
281	Methylation	HMHFGEARLGCAPRF ECCCCCCCCCCCCCH	27.58	24387993

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of METRL_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of METRL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of METRL_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of METRL_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.