ZN277_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN277_HUMAN
• UniProt AC: Q9NRM2
• Protein Name: Zinc finger protein 277
• Gene Name: ZNF277
• Organism: Homo sapiens (Human).
• Sequence Length: 450
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation..
• Protein Sequence: MAASKTQGAVARMQEDRDGSCSTVGGVGYGDSKDCILEPLSLPESPGGTTTLEGSPSVPCIFCEEHFPVAEQDKLLKHMIIEHKIVIADVKLVADFQRYILYWRKRFTEQPITDFCSVIRINSTAPFEEQENYFLLCDVLPEDRILREELQKQRLREILEQQQQERNDTNFHGVCMFCNEEFLGNRSVILNHMAREHAFNIGLPDNIVNCNEFLCTLQKKLDNLQCLYCEKTFRDKNTLKDHMRKKQHRKINPKNREYDRFYVINYLELGKSWEEVQLEDDRELLDHQEDDWSDWEEHPASAVCLFCEKQAETIEKLYVHMEDAHEFDLLKIKSELGLNFYQQVKLVNFIRRQVHQCRCYGCHVKFKSKADLRTHMEETKHTSLLPDRKTWDQLEYYFPTYENDTLLCTLSDSESDLTAQEQNENVPIISEDTSKLYALKQSSILNQLLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAASKTQGA ------CCCCCCCHH	22.05	22814378
4	Phosphorylation	----MAASKTQGAVA ----CCCCCCCHHHH	27.05	20068231
5	Ubiquitination	---MAASKTQGAVAR ---CCCCCCCHHHHH	39.89	22505724
6	Phosphorylation	--MAASKTQGAVARM --CCCCCCCHHHHHC	29.73	29052541
41	Phosphorylation	DCILEPLSLPESPGG CCEEEECCCCCCCCC	53.22	28122231
45	Phosphorylation	EPLSLPESPGGTTTL EECCCCCCCCCCEEC	27.23	28348404
49	Phosphorylation	LPESPGGTTTLEGSP CCCCCCCCEECCCCC	23.63	28348404
50	Phosphorylation	PESPGGTTTLEGSPS CCCCCCCEECCCCCC	32.43	28348404
51	Phosphorylation	ESPGGTTTLEGSPSV CCCCCCEECCCCCCC	23.73	28348404
55	Phosphorylation	GTTTLEGSPSVPCIF CCEECCCCCCCCEEE	12.48	28122231
57	Phosphorylation	TTLEGSPSVPCIFCE EECCCCCCCCEEEEC	40.15	28122231
99	Nitration	LVADFQRYILYWRKR HHHHHHHHHHHHHHC	5.63	-
102	Nitration	DFQRYILYWRKRFTE HHHHHHHHHHHCCCC	8.13	-
152	Ubiquitination	ILREELQKQRLREIL HHHHHHHHHHHHHHH	50.43	-
293	Phosphorylation	DHQEDDWSDWEEHPA HCCCCCCCHHCCCCH	39.58	-
374	Phosphorylation	KSKADLRTHMEETKH CCHHHHHHHHHHHCC	32.64	20363803
379	O-linked_Glycosylation	LRTHMEETKHTSLLP HHHHHHHHCCCCCCC	18.15	30379171
433	Phosphorylation	VPIISEDTSKLYALK CCEECCCHHHHHHHH	24.57	26074081
434	Phosphorylation	PIISEDTSKLYALKQ CEECCCHHHHHHHHH	32.74	26074081
437	Phosphorylation	SEDTSKLYALKQSSI CCCHHHHHHHHHHHH	17.39	26074081
442	Phosphorylation	KLYALKQSSILNQLL HHHHHHHHHHHHHHC	20.12	26074081
443	Phosphorylation	LYALKQSSILNQLLL HHHHHHHHHHHHHCC	28.71	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN277_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN277_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN277_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ACOT2_HUMAN	ACOT2	physical	17353931
ZBT7B_HUMAN	ZBTB7B	physical	20211142
ZN768_HUMAN	ZNF768	physical	20211142
MBD3_HUMAN	MBD3	physical	25416956
NUTM1_HUMAN	NUTM1	physical	25416956
UBE2T_HUMAN	UBE2T	physical	26186194
RN123_HUMAN	RNF123	physical	26186194
UBE2T_HUMAN	UBE2T	physical	28514442
RN123_HUMAN	RNF123	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.