ESIP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ESIP1_HUMAN
• UniProt AC: Q96J88
• Protein Name: Epithelial-stromal interaction protein 1
• Gene Name: EPSTI1
• Organism: Homo sapiens (Human).
• Sequence Length: 318
• Protein Sequence: MNTRNRVVNSGLGASPASRPTRDPQDPSGRQGELSPVEDQREGLEAAPKGPSRESVVHAGQRRTSAYTLIAPNINRRNEIQRIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYKQKLKREESVRIKKEAEEAELQKMKAIQREKSNKLEEKKRLQENLRREAFREHQQYKTAEFLSKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSWAYRDSLKAEENRKLQKMKDEQHQKSELLELKRQQQEQERAKIHQTEHRRVNNAFLDRLQGKSQPGGLEQSGGCWNMNSGNSWGI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	TRNRVVNSGLGASPA CCCCHHCCCCCCCCC	24.64	-
15	Phosphorylation	VNSGLGASPASRPTR HCCCCCCCCCCCCCC	21.14	28348404
18	Phosphorylation	GLGASPASRPTRDPQ CCCCCCCCCCCCCCC	42.02	26714015
21	Phosphorylation	ASPASRPTRDPQDPS CCCCCCCCCCCCCCC	46.74	-
35	Phosphorylation	SGRQGELSPVEDQRE CCCCCCCCCHHHHHH	23.69	22617229
52	Phosphorylation	EAAPKGPSRESVVHA HCCCCCCCHHHHHCC	58.30	-
64	Phosphorylation	VHAGQRRTSAYTLIA HCCCCCCCCEEEEEC	21.65	28857561
65	Phosphorylation	HAGQRRTSAYTLIAP CCCCCCCCEEEEECC	19.91	26657352
67	Phosphorylation	GQRRTSAYTLIAPNI CCCCCCEEEEECCCC	11.22	28857561
68	Phosphorylation	QRRTSAYTLIAPNIN CCCCCEEEEECCCCC	16.05	28857561
113	Phosphorylation	VPRRLGGSQSETEVR CCCCCCCCCCHHHHH	28.83	28857561
115	Phosphorylation	RRLGGSQSETEVRQK CCCCCCCCHHHHHHH	48.46	23312004
172	Methylation	NKLEEKKRLQENLRR CHHHHHHHHHHHHHH	53.31	-
178	Methylation	KRLQENLRREAFREH HHHHHHHHHHHHHHH	46.07	-
199 (in isoform 2)	Phosphorylation	-	48.56	23090842
201 (in isoform 2)	Phosphorylation	-	30.02	23090842
205 (in isoform 2)	Phosphorylation	-	40.55	23090842
209 (in isoform 2)	Phosphorylation	-	23.66	23090842
218	Phosphorylation	VCGPQSSTWKLPILP CCCCCCCCCCCCCCC	31.68	-
254	Ubiquitination	KLQKMKDEQHQKSEL HHHHHCHHHHHHHHH	44.43	29967540
265	Ubiquitination	KSELLELKRQQQEQE HHHHHHHHHHHHHHH	38.49	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ESIP1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ESIP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ESIP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IPSP_HUMAN	SERPINA5	physical	28514442
SNTG2_HUMAN	SNTG2	physical	28514442
CYTT_HUMAN	CST2	physical	28514442
CYTS_HUMAN	CST4	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.