STAC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STAC_HUMAN
• UniProt AC: Q99469
• Protein Name: SH3 and cysteine-rich domain-containing protein
• Gene Name: STAC
• Organism: Homo sapiens (Human).
• Sequence Length: 402
• Subcellular Localization: Cytoplasm, cytosol .
• Protein Description: Promotes expression of the ion channel CACNA1H at the cell membrane, and thereby contributes to the regulation of channel activity..
• Protein Sequence: MIPPSSPREDGVDGLPKEAVGAEQPPSPASTSSQESKLQKLKRSLSFKTKSLRSKSADNFFQRTNSEDMKLQAHMVAEISPSSSPLPAPGSLTSTPARAGLHPGGKAHAFQEYIFKKPTFCDVCNHMIVGTNAKHGLRCKACKMSIHHKCTDGLAPQRCMGKLPKGFRRYYSSPLLIHEQFGCIKEVMPIACGNKVDPVYETLRFGTSLAQRTKKGSSGSGSDSPHRTSTSDLVEVPEEANGPGGGYDLRKRSNSVFTYPENGTDDFRDPAKNINHQGSLSKDPLQMNTYVALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQRLQQNEKIFRCVRTFIGCKEQGQITLKENQICVSSEEEQDGFIRVLSGKKKGLIPLDVLENI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MIPPSSPREDGV ---CCCCCCCCCCCC	47.85	22199227
6	Phosphorylation	--MIPPSSPREDGVD --CCCCCCCCCCCCC	33.48	22199227
27	Phosphorylation	VGAEQPPSPASTSSQ CCCCCCCCCCCCCCH	39.52	28857561
30	Phosphorylation	EQPPSPASTSSQESK CCCCCCCCCCCHHHH	32.00	27732954
31	Phosphorylation	QPPSPASTSSQESKL CCCCCCCCCCHHHHH	34.21	27732954
32	Phosphorylation	PPSPASTSSQESKLQ CCCCCCCCCHHHHHH	27.77	27732954
33	Phosphorylation	PSPASTSSQESKLQK CCCCCCCCHHHHHHH	37.75	27732954
46	Phosphorylation	QKLKRSLSFKTKSLR HHHHHHHCCCCHHHH	26.41	24719451
49	Phosphorylation	KRSLSFKTKSLRSKS HHHHCCCCHHHHHCC	24.69	30576142
54	Phosphorylation	FKTKSLRSKSADNFF CCCHHHHHCCHHHHH	35.93	30576142
56	Phosphorylation	TKSLRSKSADNFFQR CHHHHHCCHHHHHHH	41.94	22199227
82	Phosphorylation	MVAEISPSSSPLPAP EEEECCCCCCCCCCC	36.34	22210691
91	Phosphorylation	SPLPAPGSLTSTPAR CCCCCCCCCCCCCCC	27.67	22210691
171	Phosphorylation	PKGFRRYYSSPLLIH CCCHHHHCCCCCHHH	10.81	27732954
172	Phosphorylation	KGFRRYYSSPLLIHE CCHHHHCCCCCHHHH	19.28	25884760
173	Phosphorylation	GFRRYYSSPLLIHEQ CHHHHCCCCCHHHHH	11.93	27732954
200	Phosphorylation	GNKVDPVYETLRFGT CCCCCHHHHHHHHCC	14.48	28674419
213	Phosphorylation	GTSLAQRTKKGSSGS CCHHHHHCCCCCCCC	25.65	-
224	Phosphorylation	SSGSGSDSPHRTSTS CCCCCCCCCCCCCCH	25.05	-
289	Phosphorylation	KDPLQMNTYVALYKF CCCCHHHHHHHEEEE	17.65	25690035
374	Phosphorylation	KENQICVSSEEEQDG ECCEEEECCHHHCCC	27.85	29978859
375	Phosphorylation	ENQICVSSEEEQDGF CCEEEECCHHHCCCE	28.73	29978859
387	Phosphorylation	DGFIRVLSGKKKGLI CCEEEECCCCCCCCE	45.79	29978859

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STAC_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STAC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STAC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LMNA_HUMAN	LMNA	physical	18654987
TRMO_HUMAN	C9orf156	physical	18654987
TRIP6_HUMAN	TRIP6	physical	18654987
SPN90_HUMAN	NCKIPSD	physical	18654987
LIMD1_HUMAN	LIMD1	physical	18654987
A4_HUMAN	APP	physical	21832049
KANK2_HUMAN	KANK2	physical	25416956
LZTS2_HUMAN	LZTS2	physical	25416956
K1958_HUMAN	KIAA1958	physical	25416956
1433Z_HUMAN	YWHAZ	physical	26186194
FBX11_HUMAN	FBXO11	physical	26186194
ANKL2_HUMAN	ANKLE2	physical	26186194
ANKL2_HUMAN	ANKLE2	physical	28514442
1433E_HUMAN	YWHAE	physical	28514442
1433Z_HUMAN	YWHAZ	physical	28514442
1433B_HUMAN	YWHAB	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.