TRMO_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRMO_HUMAN
• UniProt AC: Q9BU70
• Protein Name: tRNA (adenine(37)-N6)-methyltransferase {ECO:0000305}
• Gene Name: TRMO {ECO:0000303|PubMed:25063302, ECO:0000312|HGNC:HGNC:30967}
• Organism: Homo sapiens (Human).
• Sequence Length: 441
• Protein Description: S-adenosyl-L-methionine-dependent methyltransferase responsible for the addition of the methyl group in the formation of N6-methyl-N6-threonylcarbamoyladenosine at position 37 (m(6)t(6)A37) of the tRNA anticodon loop of tRNA(Ser)(GCU). [PubMed: 25063302 The methyl group of m(6)t(6)A37 may improve the efficiency of the tRNA decoding ability. May bind to tRNA (By similarity]
• Protein Sequence: MRGLEESGPRPTATPCGCVKPALETGNLLTEPVGYLESCFSAKNGTPRQPSICSYSRACLRIRKRIFNNPEHSLMGLEQFSHVWILFVFHKNGHLSCKAKVQPPRLNGAKTGVFSTRSPHRPNAIGLTLAKLEKVEGGAIYLSGIDMIHGTPVLDIKPYIAEYDSPQNVMEPLADFNLQNNQHTPNTVSQSDSKTDSCDQRQLSGCDEPQPHHSTKRKPKCPEDRTSEENYLTHSDTARIQQAFPMHREIAVDFGLESRRDQSSSVAEEQIGPYCPEKSFSEKGTDKKLERVEGAAVLQGSRAETQPMAPHCPAGRADGAPRSVVPAWVTEAPVATLEVRFTPHAEMDLGQLSSQDVGQASFKYFQSAEEAKRAIEAVLSADPRSVYRRKLCQDRLFYFTVDIAHVTCWFGDGFAEVLRIKPASEPVHMTGPVGSLVSLGS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
100	Ubiquitination	GHLSCKAKVQPPRLN CCEEEEEEECCCCCC		-
110	Ubiquitination	PPRLNGAKTGVFSTR CCCCCCCCEECEECC		-
118	Phosphorylation	TGVFSTRSPHRPNAI EECEECCCCCCCCCC		25159151
163	Phosphorylation	IKPYIAEYDSPQNVM CCCCEECCCCCCCCC		-
184	Phosphorylation	NLQNNQHTPNTVSQS CCCCCCCCCCCCCCC		25159151
204	Phosphorylation	SCDQRQLSGCDEPQP CCCHHHHCCCCCCCC		-
214	Phosphorylation	DEPQPHHSTKRKPKC CCCCCCCCCCCCCCC		25627689
215	Phosphorylation	EPQPHHSTKRKPKCP CCCCCCCCCCCCCCC		25627689
231	Phosphorylation	DRTSEENYLTHSDTA CCCCCCCCCCHHHHH		22468782
235	Phosphorylation	EENYLTHSDTARIQQ CCCCCCHHHHHHHHH		22468782
237	Phosphorylation	NYLTHSDTARIQQAF CCCCHHHHHHHHHHC		-
265	Phosphorylation	SRRDQSSSVAEEQIG CCCCCCCCHHHHHHC		28555341
361	Phosphorylation	SQDVGQASFKYFQSA CCCHHHHHHHHHHCH		24719451
363	Ubiquitination	DVGQASFKYFQSAEE CHHHHHHHHHHCHHH		-
372	Ubiquitination	FQSAEEAKRAIEAVL HHCHHHHHHHHHHHH		-
380	Phosphorylation	RAIEAVLSADPRSVY HHHHHHHHCCHHHHH		30257219
421	Ubiquitination	FAEVLRIKPASEPVH HHHCCEEEECCCCEE		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TRMO_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRMO_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRMO_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RHPN2_HUMAN	RHPN2	physical	26186194
STA5B_HUMAN	STAT5B	physical	28514442
RHPN2_HUMAN	RHPN2	physical	28514442
VP26B_HUMAN	VPS26B	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.