BORC5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BORC5_HUMAN
• UniProt AC: Q969J3
• Protein Name: BLOC-1-related complex subunit 5 {ECO:0000305}
• Gene Name: BORCS5 {ECO:0000312|HGNC:HGNC:17950}
• Organism: Homo sapiens (Human).
• Sequence Length: 196
• Subcellular Localization: Lysosome membrane ; Lipid-anchor ; Cytoplasmic side .
• Protein Description: As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. Thereby, it may indirectly play a role in cell spreading and motility..
• Protein Sequence: MGSEQSSEAESRPNDLNSSVTPSPAKHRAKMDDIVVVAQGSQASRNVSNDPDVIKLQEIPTFQPLLKGLLSGQTSPTNAKLEKLDSQQVLQLCLRYQDHLHQCAEAVAFDQNALVKRIKEMDLSVETLFSFMQERQKRYAKYAEQIQKVNEMSAILRRIQMGIDQTVPLLDRLNSMLPEGERLEPFSMKPDRELRL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGSEQSSEA ------CCCCCCCCC		25807930
6	Phosphorylation	--MGSEQSSEAESRP --CCCCCCCCCCCCC		-
18	Phosphorylation	SRPNDLNSSVTPSPA CCCCCCCCCCCCCHH		22199227
19	Phosphorylation	RPNDLNSSVTPSPAK CCCCCCCCCCCCHHH		27732954
21	Phosphorylation	NDLNSSVTPSPAKHR CCCCCCCCCCHHHHH		27732954
23	Phosphorylation	LNSSVTPSPAKHRAK CCCCCCCCHHHHHCC		22199227
30	Ubiquitination	SPAKHRAKMDDIVVV CHHHHHCCCCCEEEE		-
48	Phosphorylation	SQASRNVSNDPDVIK CHHHCCCCCCCCCCH		27499020
67	Ubiquitination	PTFQPLLKGLLSGQT CCHHHHHHHHHCCCC		-
71	Phosphorylation	PLLKGLLSGQTSPTN HHHHHHHCCCCCCCC		30266825
74	Phosphorylation	KGLLSGQTSPTNAKL HHHHCCCCCCCCHHH		30266825
75	Phosphorylation	GLLSGQTSPTNAKLE HHHCCCCCCCCHHHH		25159151
77	Phosphorylation	LSGQTSPTNAKLEKL HCCCCCCCCHHHHHC		30266825
80	Ubiquitination	QTSPTNAKLEKLDSQ CCCCCCHHHHHCCHH		-
161	Sulfoxidation	AILRRIQMGIDQTVP HHHHHHHHCCCCHHH		21406390
175	Phosphorylation	PLLDRLNSMLPEGER HHHHHHHHCCCCCCC		23917254
187	Phosphorylation	GERLEPFSMKPDREL CCCCCCCCCCCCCCC		24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BORC5_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
2	G	Myristoylation	Myristoylation at Gly-2 mediates attachment to lysosome membranes.	25807930

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BORC5_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of BORC5_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.