dbPTM

FRM4A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FRM4A_HUMAN
UniProt AC	Q9P2Q2
Protein Name	FERM domain-containing protein 4A
Gene Name	FRMD4A {ECO:0000312\|HGNC:HGNC:25491}
Organism	Homo sapiens (Human).
Sequence Length	1039
Subcellular Localization	Cytoplasm, cytoskeleton. Cell junction, adherens junction . Cell junction, tight junction . Colocalized with CYTH1 at adherens junction and tight junction. Colocalized with PARD3 during the process of epithelial polarization.
Protein Description	Scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex (By similarity). Plays a redundant role with FRMD4B in epithelial polarization (By similarity). May regulate MAPT secretion by activating ARF6-signaling. [PubMed: 27044754]
Protein Sequence	MAVQLVPDSALGLLMMTEGRRCQVHLLDDRKLELLVQPKLLAKELLDLVASHFNLKEKEYFGIAFTDETGHLNWLQLDRRVLEHDFPKKSGPVVLYFCVRFYIESISYLKDNATIELFFLNAKSCIYKELIDVDSEVVFELASYILQEAKGDFSSNEVVRSDLKKLPALPTQALKEHPSLAYCEDRVIEHYKKLNGQTRGQAIVNYMSIVESLPTYGVHYYAVKDKQGIPWWLGLSYKGIFQYDYHDKVKPRKIFQWRQLENLYFREKKFSVEVHDPRRASVTRRTFGHSGIAVHTWYACPALIKSIWAMAISQHQFYLDRKQSKSKIHAARSLSEIAIDLTETGTLKTSKLANMGSKGKIISGSSGSLLSSGSQESDSSQSAKKDMLAALKSRQEALEETLRQRLEELKKLCLREAELTGKLPVEYPLDPGEEPPIVRRRIGTAFKLDEQKILPKGEEAELERLEREFAIQSQITEAARRLASDPNVSKKLKKQRKTSYLNALKKLQEIENAINENRIKSGKKPTQRASLIIDDGNIASEDSSLSDALVLEDEDSQVTSTISPLHSPHKGLPPRPPSHNRPPPPQSLEGLRQMHYHRNDYDKSPIKPKMWSESSLDEPYEKVKKRSSHSHSSSHKRFPSTGSCAEAGGGSNSLQNSPIRGLPHWNSQSSMPSTPDLRVRSPHYVHSTRSVDISPTRLHSLALHFRHRSSSLESQGKLLGSENDTGSPDFYTPRTRSSNGSDPMDDCSSCTSHSSSEHYYPAQMNANYSTLAEDSPSKARQRQRQRQRAAGALGSASSGSMPNLAARGGAGGAGGAGGGVYLHSQSQPSSQYRIKEYPLYIEGGATPVVVRSLESDQEGHYSVKAQFKTSNSYTAGGLFKESWRGGGGDEGDTGRLTPSRSQILRTPSLGREGAHDKGAGRAAVSDELRQWYQRSTASHKEHSRLSHTSSTSSDSGSQYSTSSQSTFVAHSRVTRMPQMCKATSAALPQSQRSSTPSSEIGATPPSSPHHILTWQTGEATENSPILDGSESPPHQSTDE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	AVQLVPDSALGLLMM CCEECCHHHHHHHHH	21.23	24043423
17	Phosphorylation	ALGLLMMTEGRRCQV HHHHHHHCCCCEEEE	22.71	24043423
56	Acetylation	VASHFNLKEKEYFGI HHHHCCCCCHHEEEE	68.77	7667125
66	Phosphorylation	EYFGIAFTDETGHLN HEEEEEEECCCCCCC	24.73	20058876
69	Phosphorylation	GIAFTDETGHLNWLQ EEEEECCCCCCCHHH	32.48	20058876
90	Phosphorylation	EHDFPKKSGPVVLYF HCCCCCCCCCCHHEE	55.23	-
96	Phosphorylation	KSGPVVLYFCVRFYI CCCCCHHEEEEEHHH	5.37	-
324	Phosphorylation	FYLDRKQSKSKIHAA HHHCHHHHHHHHHHH	41.76	24719451
333	Phosphorylation	SKIHAARSLSEIAID HHHHHHHHHHHHCEE	31.36	29255136
335	Phosphorylation	IHAARSLSEIAIDLT HHHHHHHHHHCEEEC	28.36	29255136
342	Phosphorylation	SEIAIDLTETGTLKT HHHCEEECCCCCCCH	27.96	28102081
357	Phosphorylation	SKLANMGSKGKIISG HHHCCCCCCCCEEEC	27.71	25954137
363	Phosphorylation	GSKGKIISGSSGSLL CCCCCEEECCCCCCC	35.77	25850435
365	Phosphorylation	KGKIISGSSGSLLSS CCCEEECCCCCCCCC	25.41	25954137
366	Phosphorylation	GKIISGSSGSLLSSG CCEEECCCCCCCCCC	35.61	25850435
368	Phosphorylation	IISGSSGSLLSSGSQ EEECCCCCCCCCCCC	28.25	25850435
371	Phosphorylation	GSSGSLLSSGSQESD CCCCCCCCCCCCCCC	37.64	29255136
372	Phosphorylation	SSGSLLSSGSQESDS CCCCCCCCCCCCCCC	42.29	29255136
374	Phosphorylation	GSLLSSGSQESDSSQ CCCCCCCCCCCCCCH	32.49	29255136
377	Phosphorylation	LSSGSQESDSSQSAK CCCCCCCCCCCHHHH	34.85	29255136
379	Phosphorylation	SGSQESDSSQSAKKD CCCCCCCCCHHHHHH	39.29	25850435
380	Phosphorylation	GSQESDSSQSAKKDM CCCCCCCCHHHHHHH	32.90	25850435
382	Phosphorylation	QESDSSQSAKKDMLA CCCCCCHHHHHHHHH	43.96	25850435
530	Phosphorylation	KKPTQRASLIIDDGN CCCCCCEEEEEECCC	23.45	24275569
587	Phosphorylation	NRPPPPQSLEGLRQM CCCCCCCCHHHHHHH	33.87	22210691
601	Phosphorylation	MHYHRNDYDKSPIKP HHHCCCCCCCCCCCH	28.90	23403867
604	Phosphorylation	HRNDYDKSPIKPKMW CCCCCCCCCCCHHHC	29.03	22617229
612	Phosphorylation	PIKPKMWSESSLDEP CCCHHHCCCCCCCCC	24.89	23186163
614	Phosphorylation	KPKMWSESSLDEPYE CHHHCCCCCCCCCHH	30.59	29507054
615	Phosphorylation	PKMWSESSLDEPYEK HHHCCCCCCCCCHHH	35.47	28102081
620	Phosphorylation	ESSLDEPYEKVKKRS CCCCCCCHHHHHHHC	26.74	29978859
627	Phosphorylation	YEKVKKRSSHSHSSS HHHHHHHCCCCCCCC	41.08	29083192
628	Phosphorylation	EKVKKRSSHSHSSSH HHHHHHCCCCCCCCC	32.80	29083192
630	Phosphorylation	VKKRSSHSHSSSHKR HHHHCCCCCCCCCCC	27.32	29449344
632	Phosphorylation	KRSSHSHSSSHKRFP HHCCCCCCCCCCCCC	36.23	29449344
633	Phosphorylation	RSSHSHSSSHKRFPS HCCCCCCCCCCCCCC	30.91	29083192
634	Phosphorylation	SSHSHSSSHKRFPST CCCCCCCCCCCCCCC	35.72	29083192
640	Phosphorylation	SSHKRFPSTGSCAEA CCCCCCCCCCCCCCC	42.56	29255136
641	Phosphorylation	SHKRFPSTGSCAEAG CCCCCCCCCCCCCCC	33.09	25884760
643	Phosphorylation	KRFPSTGSCAEAGGG CCCCCCCCCCCCCCC	15.39	29255136
651	Phosphorylation	CAEAGGGSNSLQNSP CCCCCCCCCCCCCCC	26.90	24114839
653	Phosphorylation	EAGGGSNSLQNSPIR CCCCCCCCCCCCCCC	32.79	25850435
657	Phosphorylation	GSNSLQNSPIRGLPH CCCCCCCCCCCCCCC	14.56	29255136
667	Phosphorylation	RGLPHWNSQSSMPST CCCCCCCCCCCCCCC	26.67	23403867
669	Phosphorylation	LPHWNSQSSMPSTPD CCCCCCCCCCCCCCC	28.55	23403867
670	Phosphorylation	PHWNSQSSMPSTPDL CCCCCCCCCCCCCCC	27.37	23403867
673	Phosphorylation	NSQSSMPSTPDLRVR CCCCCCCCCCCCCCC	43.88	23403867
674	Phosphorylation	SQSSMPSTPDLRVRS CCCCCCCCCCCCCCC	18.23	23403867
681	Phosphorylation	TPDLRVRSPHYVHST CCCCCCCCCCCCCCC	17.11	28796482
684	Phosphorylation	LRVRSPHYVHSTRSV CCCCCCCCCCCCCCE	11.84	28796482
687	Phosphorylation	RSPHYVHSTRSVDIS CCCCCCCCCCCEECC	18.57	28796482
688	Phosphorylation	SPHYVHSTRSVDISP CCCCCCCCCCEECCC	16.46	28796482
690	Phosphorylation	HYVHSTRSVDISPTR CCCCCCCCEECCCHH	24.99	29255136
694	Phosphorylation	STRSVDISPTRLHSL CCCCEECCCHHHHHH	18.76	30266825
696	Phosphorylation	RSVDISPTRLHSLAL CCEECCCHHHHHHHH	38.79	30266825
700	Phosphorylation	ISPTRLHSLALHFRH CCCHHHHHHHHHHHH	21.67	22617229
709	Phosphorylation	ALHFRHRSSSLESQG HHHHHHCCCCHHHCC	20.39	29514088
710	Phosphorylation	LHFRHRSSSLESQGK HHHHHCCCCHHHCCE	38.61	27251789
711	Phosphorylation	HFRHRSSSLESQGKL HHHHCCCCHHHCCEE	37.09	27794612
714	Phosphorylation	HRSSSLESQGKLLGS HCCCCHHHCCEECCC	49.91	29514088
721	Phosphorylation	SQGKLLGSENDTGSP HCCEECCCCCCCCCC	32.94	30266825
725	Phosphorylation	LLGSENDTGSPDFYT ECCCCCCCCCCCCCC	51.66	30266825
727	Phosphorylation	GSENDTGSPDFYTPR CCCCCCCCCCCCCCC	24.32	30266825
731	Phosphorylation	DTGSPDFYTPRTRSS CCCCCCCCCCCCCCC	24.18	30266825
732	Phosphorylation	TGSPDFYTPRTRSSN CCCCCCCCCCCCCCC	13.29	30266825
737	Phosphorylation	FYTPRTRSSNGSDPM CCCCCCCCCCCCCCC	27.78	28787133
738	Phosphorylation	YTPRTRSSNGSDPMD CCCCCCCCCCCCCCC	41.75	28787133
741	Phosphorylation	RTRSSNGSDPMDDCS CCCCCCCCCCCCCCH	42.67	28787133
748	Phosphorylation	SDPMDDCSSCTSHSS CCCCCCCHHCCCCCC	35.13	28787133
768	Phosphorylation	PAQMNANYSTLAEDS CCCCCCCHHHHCCCC	10.71	-
795	Phosphorylation	RAAGALGSASSGSMP HHHHHHHCCCCCCCC	26.31	27794612
797	Phosphorylation	AGALGSASSGSMPNL HHHHHCCCCCCCCCH	36.61	29255136
798	Phosphorylation	GALGSASSGSMPNLA HHHHCCCCCCCCCHH	34.30	29255136
800	Phosphorylation	LGSASSGSMPNLAAR HHCCCCCCCCCHHHC	32.77	29255136
821	Phosphorylation	GGAGGGVYLHSQSQP CCCCCCEEECCCCCC	11.28	27642862
824	Phosphorylation	GGGVYLHSQSQPSSQ CCCEEECCCCCCCCC	29.00	23312004
826	Phosphorylation	GVYLHSQSQPSSQYR CEEECCCCCCCCCCC	47.26	23312004
829	Phosphorylation	LHSQSQPSSQYRIKE ECCCCCCCCCCCEEE	23.57	23312004
830	Phosphorylation	HSQSQPSSQYRIKEY CCCCCCCCCCCEEEC	37.60	23312004
832	Phosphorylation	QSQPSSQYRIKEYPL CCCCCCCCCEEECCE	19.09	23312004
837	Phosphorylation	SQYRIKEYPLYIEGG CCCCEEECCEEEECC	8.11	27642862
840	Phosphorylation	RIKEYPLYIEGGATP CEEECCEEEECCCCC	7.76	27642862
846	Phosphorylation	LYIEGGATPVVVRSL EEEECCCCCEEEEEC	21.64	25850435
852	Phosphorylation	ATPVVVRSLESDQEG CCCEEEEECCCCCCC	25.53	28796482
855	Phosphorylation	VVVRSLESDQEGHYS EEEEECCCCCCCCEE	50.30	28796482
861	Phosphorylation	ESDQEGHYSVKAQFK CCCCCCCEEEEEEEE	26.47	28796482
862	Phosphorylation	SDQEGHYSVKAQFKT CCCCCCEEEEEEEEC	16.09	28796482
868	Methylation	YSVKAQFKTSNSYTA EEEEEEEECCCCEEC	38.68	-
870	Phosphorylation	VKAQFKTSNSYTAGG EEEEEECCCCEECCE	25.11	25072903
872	Phosphorylation	AQFKTSNSYTAGGLF EEEECCCCEECCEEE	24.51	29978859
873	Phosphorylation	QFKTSNSYTAGGLFK EEECCCCEECCEEEE	12.59	23186163
874	Phosphorylation	FKTSNSYTAGGLFKE EECCCCEECCEEEEC	20.74	29978859
893	Phosphorylation	GGGDEGDTGRLTPSR CCCCCCCCCCCCCCH	34.75	29255136
897	Phosphorylation	EGDTGRLTPSRSQIL CCCCCCCCCCHHHHH	20.18	29255136
899	Phosphorylation	DTGRLTPSRSQILRT CCCCCCCCHHHHHCC	39.05	29255136
901	Phosphorylation	GRLTPSRSQILRTPS CCCCCCHHHHHCCCC	26.38	23403867
906	Phosphorylation	SRSQILRTPSLGREG CHHHHHCCCCCCCCC	17.49	23403867
908	Phosphorylation	SQILRTPSLGREGAH HHHHCCCCCCCCCCC	42.73	23403867
925	Phosphorylation	GAGRAAVSDELRQWY CCCHHHHCHHHHHHH	22.20	22199227
948	Phosphorylation	EHSRLSHTSSTSSDS HHCCCCCCCCCCCCC	22.46	28857561
949	Phosphorylation	HSRLSHTSSTSSDSG HCCCCCCCCCCCCCC	26.62	28857561
950	Phosphorylation	SRLSHTSSTSSDSGS CCCCCCCCCCCCCCC	33.20	28857561
951	Phosphorylation	RLSHTSSTSSDSGSQ CCCCCCCCCCCCCCC	31.83	28857561
952	Phosphorylation	LSHTSSTSSDSGSQY CCCCCCCCCCCCCCC	33.81	28857561
953	Phosphorylation	SHTSSTSSDSGSQYS CCCCCCCCCCCCCCC	35.56	27251789
955	Phosphorylation	TSSTSSDSGSQYSTS CCCCCCCCCCCCCCC	42.14	-
957	Phosphorylation	STSSDSGSQYSTSSQ CCCCCCCCCCCCCCC	29.87	-
961	Phosphorylation	DSGSQYSTSSQSTFV CCCCCCCCCCCCEEE	27.71	27251789
966	Phosphorylation	YSTSSQSTFVAHSRV CCCCCCCEEEECCCC	17.94	27251789
971	Phosphorylation	QSTFVAHSRVTRMPQ CCEEEECCCCCCCHH	20.78	25332170
983	Phosphorylation	MPQMCKATSAALPQS CHHHHHHHHHCCCHH	12.37	27251275
984	Phosphorylation	PQMCKATSAALPQSQ HHHHHHHHHCCCHHH	19.19	27251275
990	Phosphorylation	TSAALPQSQRSSTPS HHHCCCHHHHCCCCH	26.14	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of FRM4A_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of FRM4A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FRM4A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
YETS4_HUMAN	YEATS4	physical	22068108

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FRM4A_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-628; SER-694 ANDSER-800, AND MASS SPECTROMETRY.	19369195 [Abstract]