IL27B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IL27B_HUMAN
• UniProt AC: Q14213
• Protein Name: Interleukin-27 subunit beta
• Gene Name: EBI3
• Organism: Homo sapiens (Human).
• Sequence Length: 229
• Subcellular Localization: Secreted.
• Protein Description: Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines..
• Protein Sequence: MTPQLLLALVLWASCPPCSGRKGPPAALTLPRVQCRASRYPIAVDCSWTLPPAPNSTSPVSFIATYRLGMAARGHSWPCLQQTPTSTSCTITDVQLFSMAPYVLNVTAVHPWGSSSSFVPFITEHIIKPDPPEGVRLSPLAERQLQVQWEPPGSWPFPEIFSLKYWIRYKRQGAARFHRVGPIEATSFILRAVRPRARYYVQVAAQDLTDYGELSDWSLPATATMSLGK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	Phosphorylation	KGPPAALTLPRVQCR CCCCCCEECCCEEEC	29.95	24719451
55	N-linked_Glycosylation	WTLPPAPNSTSPVSF EECCCCCCCCCCCEE	61.09	UniProtKB CARBOHYD
105	N-linked_Glycosylation	SMAPYVLNVTAVHPW HCCCEEEEEEEECCC	21.03	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IL27B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IL27B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IL27B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CALX_HUMAN	CANX	physical	8551575
I27RA_HUMAN	IL27RA	physical	12121660
IL27A_HUMAN	IL27	physical	12121660

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.