MYH7B_HUMAN - dbPTM
MYH7B_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MYH7B_HUMAN
UniProt AC A7E2Y1
Protein Name Myosin-7B
Gene Name MYH7B
Organism Homo sapiens (Human).
Sequence Length 1983
Subcellular Localization Membrane
Peripheral membrane protein .
Protein Description Involved in muscle contraction..
Protein Sequence MSGNKRGSRASCPHRGAECLLPWAALNLQGFQLLLLHPSATAMMDVSELGESARYLRQGYQEMTKVHTIPWDGKKRVWVPDEQDAYVEAEVKSEATGGRVTVETKDQKVLMVREAELQPMNPPRFDLLEDMAMMTHLNEASVLHNLRQRYARWMIYTYSGLFCVTINPYKWLPVYTASVVAAYKGKRRSDSPPHIYAVADNAYNDMLRNRDNQSMLITGESGAGKTVNTKRVIQYFAIVAALGDGPGKKAQFLATKTGGTLEDQIIEANPAMEAFGNAKTLRNDNSSRFGKFIRIHFGPSGKLASADIDSYLLEKSRVIFQLPGERSYHVYYQILSGRKPELQDMLLLSMNPYDYHFCSQGVITVDNMNDGEELIATDHAMDILGFSVDEKCACYKIVGALLHFGNMKFKQKQREEQAEADGTESADKAAYLMGVSSGDLLKGLLHPRVRVGNEYVTKGQSVEQVVFAVGALAKATYDRLFRWLVSRINQTLDTKLPRQFFIGVLDIAGFEIFEFNSFEQLCINFTNEKLQQFFNQHMFVLEQEEYKREGIDWVFIDFGLDLQPCIDLIEKPLGILSILEEECMFPKASDASFRAKLYDNHAGKSPNFQQPRPDKKRKYQAHFEVVHYAGVVPYSIVGWLEKNKDPLNETVVPIFQKSQNRLLATLYENYAGSCSTEPPKSGVKEKRKKAASFQTVSQLHKENLNKLMTNLRATQPHFVRCIVPNENKTPGVMDAFLVLHQLRCNGVLEGIRICRQGFPNRLLYTDFRQRYRILNPSAIPDDTFMDSRKATEKLLGSLDLDHTQYQFGHTKVFFKAGLLGVLEELRDQRLAKVLTLLQARSRGRLMRLEYQRLLGGRDALFTIQWNIRAFNAVKNWSWMKLFFKMKPLLRSAQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLELTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAKYRKAQHELDDAEERADMAETQANKLRARTRDALGPKHKE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Phosphorylation---MSGNKRGSRASC
---CCCCCCCCCCCC		23.8824043423
8UbiquitinationMSGNKRGSRASCPHR
CCCCCCCCCCCCCCC		23.8223000965
10PhosphorylationGNKRGSRASCPHRGA
CCCCCCCCCCCCCCC		19.0924043423
26PhosphorylationCLLPWAALNLQGFQL
HHHCHHHHCCCCCEE		31.55-
44PhosphorylationHPSATAMMDVSELGE
CCCCCCCCCHHHHHH		13.7020068231
77UbiquitinationPWDGKKRVWVPDEQD
CCCCCCCEECCCCCC		36.8223000965
86PhosphorylationVPDEQDAYVEAEVKS
CCCCCCCEEEEEEEE		5.8920068231
108PhosphorylationTVETKDQKVLMVREA
EEEECCCEEEEEEEH		7.68-
133PhosphorylationDLLEDMAMMTHLNEA
CHHHHHHHHHHCCHH		8.47-
172PhosphorylationTINPYKWLPVYTASV
EECCCCCCEEEEHHH		23.0821955146
176PhosphorylationYKWLPVYTASVVAAY
CCCCEEEEHHHHHHH		30.8221955146
179PhosphorylationLPVYTASVVAAYKGK
CEEEEHHHHHHHCCC		34.9821955146
184PhosphorylationASVVAAYKGKRRSDS
HHHHHHHCCCCCCCC		20.3321955146
187PhosphorylationVAAYKGKRRSDSPPH
HHHHCCCCCCCCCCC		18.8521955146
193PhosphorylationKRRSDSPPHIYAVAD
CCCCCCCCCEEEEEC		5.48-
237UbiquitinationKRVIQYFAIVAALGD
HHHHHHHHHHHHHCC		52.68-
244PhosphorylationAIVAALGDGPGKKAQ
HHHHHHCCCCCHHHE		26.2529514088
245PhosphorylationIVAALGDGPGKKAQF
HHHHHCCCCCHHHEE		37.5729514088
249UbiquitinationLGDGPGKKAQFLATK
HCCCCCHHHEEEEEC		34.60-
267UbiquitinationTLEDQIIEANPAMEA
CHHHHHHHCCHHHHH		31.6023000965
279UbiquitinationMEAFGNAKTLRNDNS
HHHHCCCCCCCCCCC		35.3123000965
291UbiquitinationDNSSRFGKFIRIHFG
CCCCCCCEEEEEEEC		16.68-
315UbiquitinationIDSYLLEKSRVIFQL
HHHHHHHCCEEEEEC		3.31-
381PhosphorylationLIATDHAMDILGFSV
EEEECCHHHHHCCCC		27.58-
383PhosphorylationATDHAMDILGFSVDE
EECCHHHHHCCCCCC		41.42-
386AcetylationHAMDILGFSVDEKCA
CHHHHHCCCCCCCHH		34.33-
389PhosphorylationDILGFSVDEKCACYK
HHHCCCCCCCHHHHH		11.33-
400AcetylationACYKIVGALLHFGNM
HHHHHHHHHHHHCCC		55.60-
413PhosphorylationNMKFKQKQREEQAEA
CCCHHHHHHHHHHHH		19.8826437602
415PhosphorylationKFKQKQREEQAEADG
CHHHHHHHHHHHHCC		28.6726437602
455PhosphorylationRVRVGNEYVTKGQSV
CEEECCCEECCCCCH		29.5927251275
563PhosphorylationIDFGLDLQPCIDLIE
EECCCCCHHHHHHHH		24.94-
608PhosphorylationHAGKSPNFQQPRPDK
CCCCCCCCCCCCCCC		26.23-
625PhosphorylationKYQAHFEVVHYAGVV
HHHHHEEEEECCCCC		9.58-
631PhosphorylationEVVHYAGVVPYSIVG
EEEECCCCCCHHHHH		9.20-
650PhosphorylationNKDPLNETVVPIFQK
CCCCCCCCHHHHHHH		23.81-
667PhosphorylationNRLLATLYENYAGSC
HHHHHHHHHHCCCCC		41.3519764811
709PhosphorylationENLNKLMTNLRATQP
HHHHHHHHHHHHCCC		1.64-
735PhosphorylationKTPGVMDAFLVLHQL
CCCCHHHHHHHHHHH		37.4430257219
793PhosphorylationDSRKATEKLLGSLDL
CCHHHHHHHHCCCCC		28.54-
849PhosphorylationRGRLMRLEYQRLLGG
CCCHHHHHHHHHHCC		25.38-
876UbiquitinationAFNAVKNWSWMKLFF
HHHHCCCCCHHHHHH		46.23-
925AcetylationKRQELEETHVSITQE
HHHHHHHHCCCCHHH		40.5327452117
1098PhosphorylationKKLRMDTERAKRKLE
HHHCCCHHHHHHHHH		13.3924719451
1244PhosphorylationTVAALRRKQAEGAAE
HHHHHHHHHHHHHHH		29.19-
1246PhosphorylationAALRRKQAEGAAELG
HHHHHHHHHHHHHHH		35.68-
1281PhosphorylationRMEVDDLAANVETLT
HHHHHHHHHHHHHHH		26.1423312004
1282PhosphorylationMEVDDLAANVETLTR
HHHHHHHHHHHHHHH		24.8123312004
1289PhosphorylationANVETLTRAKASAEK
HHHHHHHHHHHHHHH		36.3922210691
1291PhosphorylationVETLTRAKASAEKLC
HHHHHHHHHHHHHHH		40.7422210691
1295PhosphorylationTRAKASAEKLCRTYE
HHHHHHHHHHHHHHH		19.3122210691
1311UbiquitinationQLSEAKIKVEELQRQ
HHHHHHHHHHHHHHH		19.06-
1354UbiquitinationISQLSRGKALAAQSL
HHHHHHHHHHHHHHH		39.4230230243
1373UbiquitinationRQLEEESKAKSALAH
HHHHHHHHHHHHHHH		19.9430230243
1390PhosphorylationQALRHDCDLLREQHE
HHHHHHHHHHHHHHH		19.8920068231
1397AcetylationDLLREQHEEEAEAQA
HHHHHHHHHHHHHHH		54.44-
1398AcetylationLLREQHEEEAEAQAE
HHHHHHHHHHHHHHH		61.13-
1399AcetylationLREQHEEEAEAQAEL
HHHHHHHHHHHHHHH		37.98-
1412UbiquitinationELQRLLSKANAEVAQ
HHHHHHHHHHHHHHH		53.5830230243
1419PhosphorylationKANAEVAQWRSKYEA
HHHHHHHHHHHHHHH		36.9326437602
1420PhosphorylationANAEVAQWRSKYEAD
HHHHHHHHHHHHHHH		50.4426437602
1423UbiquitinationEVAQWRSKYEADAIQ
HHHHHHHHHHHHHHH		56.9930230243
1432PhosphorylationEADAIQRTEELEEAK
HHHHHHHHHHHHHHH		42.35-
1548UbiquitinationLEALETLKRENKNLQ
HHHHHHHHHHCCCHH		19.2830230243
1552UbiquitinationETLKRENKNLQEEIS
HHHHHHCCCHHHHHH		50.8930230243
1606UbiquitinationALELEETKTLRIQLE
CCCHHHHCEEEEEEE		19.8430230243
1618UbiquitinationQLELSQVKAEVDRKL
EEEHHHHHHHHHHHH		11.0930230243
1686PhosphorylationGHATRQATEAQAATR
HHHHHHHHHHHHHHH		23.3124076635
1725PhosphorylationEQAQALERRASLLAA
HHHHHHHHHHHHHHH		25.70-
1767PhosphorylationERLNLLHSQNTGLLN
HHHHHHHHCCCCCCC		25.1730576142
1777AcetylationTGLLNQKKKLEADLA
CCCCCHHHHHHHHHH		58.5030586197
1778UbiquitinationGLLNQKKKLEADLAQ
CCCCHHHHHHHHHHH		73.5530230243
1782PhosphorylationQKKKLEADLAQLSGE
HHHHHHHHHHHHHHH		27.7526437602
1783PhosphorylationKKKLEADLAQLSGEV
HHHHHHHHHHHHHHH		23.2126437602
1809PhosphorylationEKAKKAITDAAMMAE
HHHHHHHHHHHHHHH		38.70-
1820UbiquitinationMMAEELKKEQDTSAH
HHHHHHHHHHCCHHH		41.9730230243
1897UbiquitinationRKHERRVKELAYQAE
HHHHHHHHHHHHHHH		25.7630230243
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MYH7B_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MYH7B_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MYH7B_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SMYD1_HUMANSMYD1physical
23455924
ACON_HUMANACO2physical
26344197
ACTN4_HUMANACTN4physical
26344197
ALDOA_HUMANALDOAphysical
26344197
ALDOC_HUMANALDOCphysical
26344197
KCRB_HUMANCKBphysical
26344197
GPD1L_HUMANGPD1Lphysical
26344197
TPM1_HUMANTPM1physical
26344197
TPM3_HUMANTPM3physical
26344197
TPM4_HUMANTPM4physical
26344197
CA2D1_HUMANCACNA2D1physical
26496610
IMA3_HUMANKPNA4physical
26496610
RBBP5_HUMANRBBP5physical
26496610
SEC62_HUMANSEC62physical
26496610
FXR1_HUMANFXR1physical
26496610
BCLF1_HUMANBCLAF1physical
26496610
PDCD6_HUMANPDCD6physical
26496610
SRRM1_HUMANSRRM1physical
26496610
NCBP2_HUMANNCBP2physical
26496610
RT27_HUMANMRPS27physical
26496610
TP4AP_HUMANTRPC4APphysical
26496610
CSN7B_HUMANCOPS7Bphysical
26496610
PDIP3_HUMANPOLDIP3physical
26496610
PGAM5_HUMANPGAM5physical
26496610
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MYH7B_HUMAN

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Related Literatures of Post-Translational Modification

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