FA83A_HUMAN - dbPTM
FA83A_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FA83A_HUMAN
UniProt AC Q86UY5
Protein Name Protein FAM83A {ECO:0000305}
Gene Name FAM83A {ECO:0000312|HGNC:HGNC:28210}
Organism Homo sapiens (Human).
Sequence Length 434
Subcellular Localization Cytoplasm .
Protein Description Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both RAS/MAPK and PI3K/AKT/TOR signaling cascades downstream of EGFR. Required for the RAS/MAPK signaling cascade activation upon EGFR stimulation, it also activates both signaling cascades independently of EGFR activation..
Protein Sequence MSRSRHLGKIRKRLEDVKSQWVRPARADFSDNESARLATDALLDGGSEAYWRVLSQEGEVDFLSSVEAQYIQAQAREPPCPPDTLGGAEAGPKGLDSSSLQSGTYFPVASEGSEPALLHSWASAEKPYLKEKSSATVYFQTVKHNNIRDLVRRCITRTSQVLVILMDVFTDVEIFCDILEAANKRGVFVCVLLDQGGVKLFQEMCDKVQISDSHLKNISIRSVEGEIYCAKSGRKFAGQIREKFIISDWRFVLSGSYSFTWLCGHVHRNILSKFTGQAVELFDEEFRHLYASSKPVMGLKSPRLVAPVPPGAAPANGRLSSSSGSASDRTSSNPFSGRSAGSHPGTRSVSASSGPCSPAAPHPPPPPRFQPHQGPWGAPSPQAHLSPRPHDGPPAAVYSNLGAYRPTRLQLEQLGLVPRLTPTWRPFLQASPHF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSRSRHLGK
------CCCHHHHHH		38.6819413330
4Phosphorylation----MSRSRHLGKIR
----CCCHHHHHHHH		19.4219413330
18UbiquitinationRKRLEDVKSQWVRPA
HHHHHHHHHCCCCCC		49.6129967540
30PhosphorylationRPARADFSDNESARL
CCCCCCCCCCHHHHH		39.8225262027
34PhosphorylationADFSDNESARLATDA
CCCCCCHHHHHHHHH		25.5825262027
47PhosphorylationDALLDGGSEAYWRVL
HHHHCCCCHHHHHHH		25.2823917254
50PhosphorylationLDGGSEAYWRVLSQE
HCCCCHHHHHHHCCC		6.9523186163
55PhosphorylationEAYWRVLSQEGEVDF
HHHHHHHCCCCCCEE		24.2726434776
64PhosphorylationEGEVDFLSSVEAQYI
CCCCEEHHHHHHHHH		32.1226434776
93UbiquitinationGGAEAGPKGLDSSSL
CCCCCCCCCCCHHHC		71.7929967540
97PhosphorylationAGPKGLDSSSLQSGT
CCCCCCCHHHCCCCC		27.2026356563
98PhosphorylationGPKGLDSSSLQSGTY
CCCCCCHHHCCCCCE		34.4326356563
99PhosphorylationPKGLDSSSLQSGTYF
CCCCCHHHCCCCCEE		34.0926356563
102PhosphorylationLDSSSLQSGTYFPVA
CCHHHCCCCCEEECC		38.0926356563
104PhosphorylationSSSLQSGTYFPVASE
HHHCCCCCEEECCCC		27.5126356563
105PhosphorylationSSLQSGTYFPVASEG
HHCCCCCEEECCCCC		14.9226356563
110PhosphorylationGTYFPVASEGSEPAL
CCEEECCCCCCCCCC		42.6026356563
113PhosphorylationFPVASEGSEPALLHS
EECCCCCCCCCCCCC		36.0326356563
120PhosphorylationSEPALLHSWASAEKP
CCCCCCCCCHHCCCC		25.0626356563
123PhosphorylationALLHSWASAEKPYLK
CCCCCCHHCCCCCCC		30.6026356563
126UbiquitinationHSWASAEKPYLKEKS
CCCHHCCCCCCCCCC		38.3829967540
128PhosphorylationWASAEKPYLKEKSSA
CHHCCCCCCCCCCCC		41.2826356563
130UbiquitinationSAEKPYLKEKSSATV
HCCCCCCCCCCCCEE		58.2029967540
133PhosphorylationKPYLKEKSSATVYFQ
CCCCCCCCCCEEEEE		26.7119835603
134PhosphorylationPYLKEKSSATVYFQT
CCCCCCCCCEEEEEE		38.7419835603
136PhosphorylationLKEKSSATVYFQTVK
CCCCCCCEEEEEECC		20.0719835603
138PhosphorylationEKSSATVYFQTVKHN
CCCCCEEEEEECCCC		5.8928152594
141PhosphorylationSATVYFQTVKHNNIR
CCEEEEEECCCCCHH		22.9427259358
179UbiquitinationVEIFCDILEAANKRG
HHHHHHHHHHHHHCC		2.0429967540
211PhosphorylationMCDKVQISDSHLKNI
HHHHCCCCHHHHCCC		18.9030631047
213PhosphorylationDKVQISDSHLKNISI
HHCCCCHHHHCCCEE		24.7530631047
216UbiquitinationQISDSHLKNISIRSV
CCCHHHHCCCEEEEE		46.9729967540
228PhosphorylationRSVEGEIYCAKSGRK
EEECCEEEEECCCCC		5.0923917254
231UbiquitinationEGEIYCAKSGRKFAG
CCEEEEECCCCCCCC		50.2929967540
235UbiquitinationYCAKSGRKFAGQIRE
EEECCCCCCCCHHHH		42.9929967540
238UbiquitinationKSGRKFAGQIREKFI
CCCCCCCCHHHHCEE		26.9529967540
283 (in isoform 2)Phosphorylation-68.1129743597
286 (in isoform 2)Phosphorylation-5.8529743597
290PhosphorylationDEEFRHLYASSKPVM
CHHHHHHHHHCCCCC		9.79-
292PhosphorylationEFRHLYASSKPVMGL
HHHHHHHHCCCCCCC		25.9026434776
293PhosphorylationFRHLYASSKPVMGLK
HHHHHHHCCCCCCCC		32.5726434776
294AcetylationRHLYASSKPVMGLKS
HHHHHHCCCCCCCCC		38.8530588709
294UbiquitinationRHLYASSKPVMGLKS
HHHHHHCCCCCCCCC		38.8529967540
301PhosphorylationKPVMGLKSPRLVAPV
CCCCCCCCCCEEECC		21.9425106551
320PhosphorylationAPANGRLSSSSGSAS
CCCCCCCCCCCCCCC		27.1522496350
327PhosphorylationSSSSGSASDRTSSNP
CCCCCCCCCCCCCCC		29.3523186163
330PhosphorylationSGSASDRTSSNPFSG
CCCCCCCCCCCCCCC		41.3123927012
331PhosphorylationGSASDRTSSNPFSGR
CCCCCCCCCCCCCCC		29.0723927012
332PhosphorylationSASDRTSSNPFSGRS
CCCCCCCCCCCCCCC		48.1623927012
336PhosphorylationRTSSNPFSGRSAGSH
CCCCCCCCCCCCCCC		34.26-
342PhosphorylationFSGRSAGSHPGTRSV
CCCCCCCCCCCCCEE		26.6524719451
342 (in isoform 3)Phosphorylation-26.6524719451
348PhosphorylationGSHPGTRSVSASSGP
CCCCCCCEECCCCCC		21.9121082442
350PhosphorylationHPGTRSVSASSGPCS
CCCCCEECCCCCCCC		24.5520873877
352PhosphorylationGTRSVSASSGPCSPA
CCCEECCCCCCCCCC		28.4621082442
353PhosphorylationTRSVSASSGPCSPAA
CCEECCCCCCCCCCC		46.6118669648
357PhosphorylationSASSGPCSPAAPHPP
CCCCCCCCCCCCCCC		22.2525159151
380PhosphorylationQGPWGAPSPQAHLSP
CCCCCCCCCCCCCCC		29.1620873877
386PhosphorylationPSPQAHLSPRPHDGP
CCCCCCCCCCCCCCC		14.7020873877
398PhosphorylationDGPPAAVYSNLGAYR
CCCCCHHHCCCCCCC		6.2622817900
399PhosphorylationGPPAAVYSNLGAYRP
CCCCHHHCCCCCCCC		20.98-
404PhosphorylationVYSNLGAYRPTRLQL
HHCCCCCCCCCCHHH		18.48-
407PhosphorylationNLGAYRPTRLQLEQL
CCCCCCCCCHHHHHC		34.71-
431PhosphorylationWRPFLQASPHF----
CHHHHHCCCCC----		13.1223186163
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FA83A_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FA83A_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FA83A_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MGT5B_HUMANMGAT5Bphysical
25416956
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FA83A_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-348; SER-352 ANDSER-353, AND MASS SPECTROMETRY.

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