BTBD3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BTBD3_HUMAN
• UniProt AC: Q9Y2F9
• Protein Name: BTB/POZ domain-containing protein 3
• Gene Name: BTBD3
• Organism: Homo sapiens (Human).
• Sequence Length: 522
• Subcellular Localization: Cytoplasm, cytosol. Nucleus. Translocates from the cytosol to the nucleus in response to neuronal activity..
• Protein Description: Acts as a key regulator of dendritic field orientation during development of sensory cortex. Also directs dendrites toward active axon terminals when ectopically expressed (By similarity)..
• Protein Sequence: MVDDKEKNMKCLTFFLMLPETVKNRSKKSSKKANTSSSSSNSSKLPPVCYEIITLKTKKKKMAADIFPRKKPANSSSTSVQQYHQQNLSNNNLIPAPNWQGLYPTIRERNAMMFNNDLMADVHFVVGPPGGTQRLPGHKYVLAVGSSVFHAMFYGELAEDKDEIRIPDVEPAAFLAMLKYIYCDEIDLAADTVLATLYAAKKYIVPHLARACVNFLETSLSAKNACVLLSQSCLFEEPDLTQRCWEVIDAQAELALKSEGFCDIDFQTLESILRRETLNAKEIVVFEAALNWAEVECQRQDLALSIENKRKVLGKALYLIRIPTMALDDFANGAAQSGVLTLNETNDIFLWYTAAKKPELQFVSKARKGLVPQRCHRFQSCAYRSNQWRYRGRCDSIQFAVDKRVFIAGFGLYGSSCGSAEYSAKIELKRQGVVLGQNLSKYFSDGSSNTFPVWFEYPVQIEPDTFYTASVILDGNELSYFGQEGMTEVQCGKVTVQFQCSSDSTNGTGVQGGQIPELIFYA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26	Phosphorylation	PETVKNRSKKSSKKA HHHHHHCCHHCCCCC	54.55	-
27	Ubiquitination	ETVKNRSKKSSKKAN HHHHHCCHHCCCCCC	54.13	-
29	Phosphorylation	VKNRSKKSSKKANTS HHHCCHHCCCCCCCC	51.64	-
30	Phosphorylation	KNRSKKSSKKANTSS HHCCHHCCCCCCCCC	47.24	-
36	Phosphorylation	SSKKANTSSSSSNSS CCCCCCCCCCCCCCC	28.20	-
37	Phosphorylation	SKKANTSSSSSNSSK CCCCCCCCCCCCCCC	32.00	-
38	Phosphorylation	KKANTSSSSSNSSKL CCCCCCCCCCCCCCC	37.24	-
39	Phosphorylation	KANTSSSSSNSSKLP CCCCCCCCCCCCCCC	35.17	-
40	Phosphorylation	ANTSSSSSNSSKLPP CCCCCCCCCCCCCCC	42.55	-
42	Phosphorylation	TSSSSSNSSKLPPVC CCCCCCCCCCCCCCE	30.69	-
43	Phosphorylation	SSSSSNSSKLPPVCY CCCCCCCCCCCCCEE	42.32	-
132	Phosphorylation	VVGPPGGTQRLPGHK EECCCCCCCCCCCCC	19.21	25072903
201	Ubiquitination	LATLYAAKKYIVPHL HHHHHHHHHHHHHHH	37.63	-
202	Ubiquitination	ATLYAAKKYIVPHLA HHHHHHHHHHHHHHH	35.17	-
223	Ubiquitination	LETSLSAKNACVLLS HHHHCCHHHHHHHCC	41.52	-
254	Ubiquitination	VIDAQAELALKSEGF HHHHHHHHHHCCCCC	8.30	21890473
268	Phosphorylation	FCDIDFQTLESILRR CCCCCHHHHHHHHHH	32.27	22468782
271	Phosphorylation	IDFQTLESILRRETL CCHHHHHHHHHHCCC	30.00	22468782
309	Ubiquitination	LALSIENKRKVLGKA HHHEEHHHHHHHHHH	40.58	-
315	Ubiquitination	NKRKVLGKALYLIRI HHHHHHHHHHHHHCC	30.93	21890473
318	Phosphorylation	KVLGKALYLIRIPTM HHHHHHHHHHCCCCH	12.63	-
357	Ubiquitination	LWYTAAKKPELQFVS EEEECCCCCHHHHHH	38.71	-
365	Ubiquitination	PELQFVSKARKGLVP CHHHHHHHHCCCCCC	47.08	-
368	Ubiquitination	QFVSKARKGLVPQRC HHHHHHCCCCCCCCC	62.55	-
403	Ubiquitination	SIQFAVDKRVFIAGF CCCEECCCCEEEEEE	43.81	-
419	Phosphorylation	LYGSSCGSAEYSAKI ECCCCCCCCHHHEEE	23.43	-
422	Phosphorylation	SSCGSAEYSAKIELK CCCCCCHHHEEEEEE	17.41	-
440	Phosphorylation	VVLGQNLSKYFSDGS EEECEEHHHHCCCCC	32.62	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BTBD3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BTBD3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BTBD3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of BTBD3_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.