GLT11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GLT11_HUMAN
• UniProt AC: Q8NCW6
• Protein Name: Polypeptide N-acetylgalactosaminyltransferase 11
• Gene Name: GALNT11
• Organism: Homo sapiens (Human).
• Sequence Length: 608
• Subcellular Localization: Golgi apparatus membrane ; Single-pass type II membrane protein .
• Protein Description: Polypeptide N-acetylgalactosaminyltransferase that catalyzes the initiation of protein O-linked glycosylation and is involved in left/right asymmetry by mediating O-glycosylation of NOTCH1. O-glycosylation of NOTCH1 promotes activation of NOTCH1, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). Polypeptide N-acetylgalactosaminyltransferases catalyze the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays the same enzyme activity toward MUC1, MUC4, and EA2 than GALNT1. Not involved in glycosylation of erythropoietin (EPO)..
• Protein Sequence: MGSVTVRYFCYGCLFTSATWTVLLFVYFNFSEVTQPLKNVPVKGSGPHGPSPKKFYPRFTRGPSRVLEPQFKANKIDDVIDSRVEDPEEGHLKFSSELGMIFNERDQELRDLGYQKHAFNMLISDRLGYHRDVPDTRNAACKEKFYPPDLPAASVVICFYNEAFSALLRTVHSVIDRTPAHLLHEIILVDDDSDFDDLKGELDEYVQKYLPGKIKVIRNTKREGLIRGRMIGAAHATGEVLVFLDSHCEVNVMWLQPLLAAIREDRHTVVCPVIDIISADTLAYSSSPVVRGGFNWGLHFKWDLVPLSELGRAEGATAPIKSPTMAGGLFAMNRQYFHELGQYDSGMDIWGGENLEISFRIWMCGGKLFIIPCSRVGHIFRKRRPYGSPEGQDTMTHNSLRLAHVWLDEYKEQYFSLRPDLKTKSYGNISERVELRKKLGCKSFKWYLDNVYPEMQISGSHAKPQQPIFVNRGPKRPKVLQRGRLYHLQTNKCLVAQGRPSQKGGLVVLKACDYSDPNQIWIYNEEHELVLNSLLCLDMSETRSSDPPRLMKCHGSGGSQQWTFGKNNRLYQVSVGQCLRAVDPLGQKGSVAMAICDGSSSQQWHLEG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MGSVTVRYFCYG ---CCCEEHHHEEHH	10.85	24719451
82	Phosphorylation	KIDDVIDSRVEDPEE CCHHHHHCCCCCCCC	27.40	25850435
95	Phosphorylation	EEGHLKFSSELGMIF CCCCCCCCHHHHCCC	22.70	-
388	Phosphorylation	RKRRPYGSPEGQDTM HCCCCCCCCCCCCCC	17.59	28857561
414	Phosphorylation	LDEYKEQYFSLRPDL HHHHHHHHHHCCCCC	9.02	-
425	Phosphorylation	RPDLKTKSYGNISER CCCCCCCCCCCHHHH	43.43	22210691
426	Phosphorylation	PDLKTKSYGNISERV CCCCCCCCCCHHHHH	18.75	22210691
428	N-linked_Glycosylation	LKTKSYGNISERVEL CCCCCCCCHHHHHHH	26.78	UniProtKB CARBOHYD
460	O-linked_Glycosylation	PEMQISGSHAKPQQP CCCCCCCCCCCCCCC	17.30	OGP
533	Phosphorylation	EHELVLNSLLCLDMS CHHHHHHHHEEECCC	20.68	-
540	Phosphorylation	SLLCLDMSETRSSDP HHEEECCCCCCCCCC	35.17	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GLT11_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GLT11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GLT11_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of GLT11_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.