HXC13_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HXC13_HUMAN
• UniProt AC: P31276
• Protein Name: Homeobox protein Hox-C13
• Gene Name: HOXC13
• Organism: Homo sapiens (Human).
• Sequence Length: 330
• Subcellular Localization: Nucleus.
• Protein Description: Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes (By similarity)..
• Protein Sequence: MTTSLLLHPRWPESLMYVYEDSAAESGIGGGGGGGGGGTGGAGGGCSGASPGKAPSMDGLGSSCPASHCRDLLPHPVLGRPPAPLGAPQGAVYTDIPAPEAARQCAPPPAPPTSSSATLGYGYPFGGSYYGCRLSHNVNLQQKPCAYHPGDKYPEPSGALPGDDLSSRAKEFAFYPSFASSYQAMPGYLDVSVVPGISGHPEPRHDALIPVEGYQHWALSNGWDSQVYCSKEQSQSAHLWKSPFPDVVPLQPEVSSYRRGRKKRVPYTKVQLKELEKEYAASKFITKEKRRRISATTNLSERQVTIWFQNRRVKEKKVVSKSKAPHLHST

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
143	Acetylation	HNVNLQQKPCAYHPG CCCCCCCCCCCCCCC	29.15	26051181
225	Phosphorylation	ALSNGWDSQVYCSKE HHHCCCCCEEEECHH	18.29	24972180
234	Phosphorylation	VYCSKEQSQSAHLWK EEECHHHHHCCCCCC	27.48	25159151
236	Phosphorylation	CSKEQSQSAHLWKSP ECHHHHHCCCCCCCC	23.93	28348404
241	Ubiquitination	SQSAHLWKSPFPDVV HHCCCCCCCCCCCCC	55.39	29967540
273	Ubiquitination	PYTKVQLKELEKEYA CCCHHHHHHHHHHHH	43.07	29967540
279	Phosphorylation	LKELEKEYAASKFIT HHHHHHHHHHHHHCC	20.66	27811184
282	Phosphorylation	LEKEYAASKFITKEK HHHHHHHHHHCCHHH	21.67	27811184
286	Phosphorylation	YAASKFITKEKRRRI HHHHHHCCHHHHHHC	35.96	27811184
294	Phosphorylation	KEKRRRISATTNLSE HHHHHHCCCCCCCCH	20.11	-
296	Phosphorylation	KRRRISATTNLSERQ HHHHCCCCCCCCHHH	14.93	-
300	Phosphorylation	ISATTNLSERQVTIW CCCCCCCCHHHEEEE	32.57	-
330	Phosphorylation	KAPHLHST------- CCCCCCCC-------	31.70	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HXC13_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HXC13_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HXC13_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NR2E3_HUMAN	NR2E3	physical	20211142
RHXF2_HUMAN	RHOXF2	physical	20211142
ELF1_HUMAN	ELF1	physical	18692240

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.