dbPTM

ARRS_BOVIN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ARRS_BOVIN
UniProt AC	P08168
Protein Name	S-arrestin
Gene Name	SAG
Organism	Bos taurus (Bovine).
Sequence Length	404
Subcellular Localization	Isoform A: Cell projection, cilium, photoreceptor outer segment . Membrane Peripheral membrane protein . Highly expressed in photoreceptor outer segments in light-exposed retina (PubMed:7515057). Evenly distributed throughout rod photoreceptor cell
Protein Description	Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G-proteins by competing with G-proteins for the same binding site on RHO. [PubMed: 8003967]
Protein Sequence	MKANKPAPNHVIFKKISRDKSVTIYLGKRDYIDHVERVEPVDGVVLVDPELVKGKRVYVSLTCAFRYGQEDIDVMGLSFRRDLYFSQVQVFPPVGASGATTRLQESLIKKLGANTYPFLLTFPDYLPCSVMLQPAPQDVGKSCGVDFEIKAFATHSTDVEEDKIPKKSSVRLLIRKVQHAPRDMGPQPRAEASWQFFMSDKPLRLAVSLSKEIYYHGEPIPVTVAVTNSTEKTVKKIKVLVEQVTNVVLYSSDYYIKTVAAEEAQEKVPPNSSLTKTLTLVPLLANNRERRGIALDGKIKHEDTNLASSTIIKEGIDKTVMGILVSYQIKVKLTVSGLLGELTSSEVATEVPFRLMHPQPEDPDTAKESFQDENFVFEEFARQNLKDAGEYKEEKTDQEAAMDE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MKANKPAP -------CCCCCCCC	9.26	3478675
2	Acetylation	------MKANKPAPN ------CCCCCCCCC	61.74	-
5	Acetylation	---MKANKPAPNHVI ---CCCCCCCCCCEE	47.63	-
28	Acetylation	SVTIYLGKRDYIDHV CEEEEEECCHHCCCE	39.23	-
163	Acetylation	STDVEEDKIPKKSSV CCCCCCCCCCCCHHH	65.28	-
166	Acetylation	VEEDKIPKKSSVRLL CCCCCCCCCHHHHHH	69.62	-
167	Acetylation	EEDKIPKKSSVRLLI CCCCCCCCHHHHHHH	42.48	-
176	Acetylation	SVRLLIRKVQHAPRD HHHHHHHHHHCCCCC	38.97	-
201	Acetylation	WQFFMSDKPLRLAVS EEEHHCCCCCEEEEE	38.35	-
211	Acetylation	RLAVSLSKEIYYHGE EEEEEECCEEEECCC	54.12	-
230	Phosphorylation	TVAVTNSTEKTVKKI EEEECCCCHHHHHHH	43.50	-
232	Acetylation	AVTNSTEKTVKKIKV EECCCCHHHHHHHHH	59.72	-
235	Acetylation	NSTEKTVKKIKVLVE CCCHHHHHHHHHHHH	54.75	-
236	Acetylation	STEKTVKKIKVLVEQ CCHHHHHHHHHHHHH	43.34	-
238	Acetylation	EKTVKKIKVLVEQVT HHHHHHHHHHHHHHH	38.09	-
267	Acetylation	AAEEAQEKVPPNSSL CHHHHHHHCCCCCCH	48.22	-
276	Acetylation	PPNSSLTKTLTLVPL CCCCCHHCEEEHHHH	46.99	-
298	Acetylation	RGIALDGKIKHEDTN CCEECCCCCCCCCCC	48.53	-
300	Acetylation	IALDGKIKHEDTNLA EECCCCCCCCCCCCC	44.41	-
367	Acetylation	PEDPDTAKESFQDEN CCCCCCHHHHHCCCC	56.85	-
386	Acetylation	EFARQNLKDAGEYKE HHHHHHCHHHHCCCC	53.75	-
392	Acetylation	LKDAGEYKEEKTDQE CHHHHCCCCHHCHHH	55.91	-
395	Acetylation	AGEYKEEKTDQEAAM HHCCCCHHCHHHHHH	59.50	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ARRS_BOVIN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ARRS_BOVIN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ARRS_BOVIN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ARRS_BOVIN !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ARRS_BOVIN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Primary and secondary structure of bovine retinal S antigen (48-kDaprotein)."; Shinohara T., Dietzschold B., Craft C.M., Wistow G., Early J.J.,Donoso L.A., Horwitz J., Tao R.; Proc. Natl. Acad. Sci. U.S.A. 84:6975-6979(1987). Cited for: NUCLEOTIDE SEQUENCE [MRNA].	3478675 [Abstract]