K1C12_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: K1C12_HUMAN
• UniProt AC: Q99456
• Protein Name: Keratin, type I cytoskeletal 12
• Gene Name: KRT12
• Organism: Homo sapiens (Human).
• Sequence Length: 494
• Protein Description: May play a unique role in maintaining the normal corneal epithelial function. Together with KRT3, essential for the maintenance of corneal epithelium integrity (By similarity)..
• Protein Sequence: MDLSNNTMSLSVRTPGLSRRLSSQSVIGRPRGMSASSVGSGYGGSAFGFGASCGGGFSAASMFGSSSGFGGGSGSSMAGGLGAGYGRALGGGSFGGLGMGFGGSPGGGSLGILSGNDGGLLSGSEKETMQNLNDRLASYLDKVRALEEANTELENKIREWYETRGTGTADASQSDYSKYYPLIEDLRNKIISASIGNAQLLLQIDNARLAAEDFRMKYENELALRQGVEADINGLRRVLDELTLTRTDLEMQIESLNEELAYMKKNHEDELQSFRVGGPGEVSVEMDAAPGVDLTRLLNDMRAQYETIAEQNRKDAEAWFIEKSGELRKEISTNTEQLQSSKSEVTDLRRAFQNLEIELQSQLAMKKSLEDSLAEAEGDYCAQLSQVQQLISNLEAQLLQVRADAERQNVDHQRLLNVKARLELEIETYRRLLDGEAQGDGLEESLFVTDSKSQAQSTDSSKDPTKTRKIKTVVQEMVNGEVVSSQVQEIEELM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MDLSNNTMSLS ----CCCCCCCEEEE	24.62	29978859
7	Phosphorylation	-MDLSNNTMSLSVRT -CCCCCCCEEEEECC	16.64	29978859
9	Phosphorylation	DLSNNTMSLSVRTPG CCCCCCEEEEECCCC	18.56	20860994
11	Phosphorylation	SNNTMSLSVRTPGLS CCCCEEEEECCCCHH	11.40	29978859
14	Phosphorylation	TMSLSVRTPGLSRRL CEEEEECCCCHHHCC	21.39	24043423
18	Phosphorylation	SVRTPGLSRRLSSQS EECCCCHHHCCCCCC	22.67	24043423
22	Phosphorylation	PGLSRRLSSQSVIGR CCHHHCCCCCCCCCC	25.23	26699800
128	Phosphorylation	LSGSEKETMQNLNDR CCCCHHHHHHHHHHH	34.81	28355574
138	Phosphorylation	NLNDRLASYLDKVRA HHHHHHHHHHHHHHH	30.71	25106551
139	Phosphorylation	LNDRLASYLDKVRAL HHHHHHHHHHHHHHH	17.20	21082442
142	Ubiquitination	RLASYLDKVRALEEA HHHHHHHHHHHHHHH	30.90	21987572
142	Acetylation	RLASYLDKVRALEEA HHHHHHHHHHHHHHH	30.90	24790013
161	Phosphorylation	ENKIREWYETRGTGT HHHHHHHHHHCCCCC	11.58	-
163	Phosphorylation	KIREWYETRGTGTAD HHHHHHHHCCCCCCC	20.78	-
179	Phosphorylation	SQSDYSKYYPLIEDL CHHHHHHHHHHHHHH	12.36	20860994
180	Phosphorylation	QSDYSKYYPLIEDLR HHHHHHHHHHHHHHH	8.69	22817900
189	Ubiquitination	LIEDLRNKIISASIG HHHHHHHHHHHEECC	34.68	-
262	Phosphorylation	SLNEELAYMKKNHED HHHHHHHHHHHCCHH	23.30	-
314	Ubiquitination	TIAEQNRKDAEAWFI HHHHHHHHHHHHHHH	69.69	22817900
343	Phosphorylation	EQLQSSKSEVTDLRR HHHHHCHHHHHHHHH	38.97	24719451
429	Phosphorylation	LELEIETYRRLLDGE HHHHHHHHHHHHCCC	4.87	-
457	Phosphorylation	DSKSQAQSTDSSKDP CCHHHCCCCCCCCCC	36.88	22210691
458	Phosphorylation	SKSQAQSTDSSKDPT CHHHCCCCCCCCCCC	28.02	22210691
460	Phosphorylation	SQAQSTDSSKDPTKT HHCCCCCCCCCCCCH	39.10	29083192
461	Phosphorylation	QAQSTDSSKDPTKTR HCCCCCCCCCCCCHH	43.84	29083192
465	Phosphorylation	TDSSKDPTKTRKIKT CCCCCCCCCHHHHHH	56.00	29083192
467	Phosphorylation	SSKDPTKTRKIKTVV CCCCCCCHHHHHHHH	39.41	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of K1C12_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of K1C12_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of K1C12_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of K1C12_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 122100: Corneal dystrophy, Meesmann (MECD)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00400: Griseofulvin