dbPTM

ASXL2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ASXL2_HUMAN
UniProt AC	Q76L83
Protein Name	Putative Polycomb group protein ASXL2
Gene Name	ASXL2
Organism	Homo sapiens (Human).
Sequence Length	1435
Subcellular Localization	Nucleus .
Protein Description	Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3..
Protein Sequence	MREKGRRKKGRTWAEAAKTVLEKYPNTPMSHKEILQVIQREGLKEIRSGTSPLACLNAMLHTNSRGEEGIFYKVPGRMGVYTLKKDVPDGVKELSEGSEESSDGQSDSQSSENSSSSSDGGSNKEGKKSRWKRKVSSSSPQSGCPSPTIPAGKVISPSQKHSKKALKQALKQQQQKKQQQQCRPSISISSNQHLSLKTVKAASDSVPAKPATWEGKQSDGQTGSPQNSNSSFSSSVKVENTLLGLGKKSFQRSERLHTRQMKRTKCADIDVETPDSILVNTNLRALINKHTFSVLPGDCQQRLLLLLPEVDRQVGPDGLMKLNGSALNNEFFTSAAQGWKERLSEGEFTPEMQVRIRQEIEKEKKVEPWKEQFFESYYGQSSGLSLEDSKKLTASPSDPKVKKTPAEQPKSMPVSEASLIRIVPVVSQSECKEEALQMSSPGRKEECESQGEVQPNFSTSSEPLLSSALNTHELSSILPIKCPKDEDLLEQKPVTSAEQESEKNHLTTASNYNKSESQESLVTSPSKPKSPGVEKPIVKPTAGAGPQETNMKEPLATLVDQSPESLKRKSSLTQEEAPVSWEKRPRVTENRQHQQPFQVSPQPFLNRGDRIQVRKVPPLKIPVSRISPMPFHPSQVSPRARFPVSITSPNRTGARTLADIKAKAQLVKAQRAAAAAAAAAAAAASVGGTIPGPGPGGGQGPGEGGEGQTARGGSPGSDRVSETGKGPTLELAGTGSRGGTRELLPCGPETQPQSETKTTPSQAQPHSVSGAQLQQTPPVPPTPAVSGACTSVPSPAHIEKLDNEKLNPTRATATVASVSHPQGPSSCRQEKAPSPTGPALISGASPVHCAADGTVELKAGPSKNIPNPSASSKTDASVPVAVTPSPLTSLLTTATLEKLPVPQVSATTAPAGSAPPSSTLPAASSLKTPGTSLNMNGPTLRPTSSIPANNPLVTQLLQGKDVPMEQILPKPLTKVEMKTVPLTAKEERGMGALIATNTTENSTREEVNERQSHPATQQQLGKTLQSKQLPQVPRPLQLFSAKELRDSSIDTHQYHEGLSKATQDQILQTLIQRVRRQNLLSVVPPSQFNFAHSGFQLEDISTSQRFMLGFAGRRTSKPAMAGHYLLNISTYGRGSESFRRTHSVNPEDRFCLSSPTEALKMGYTDCKNATGESSSSKEDDTDEESTGDEQESVTVKEEPQVSQSAGKGDTSSGPHSRETLSTSDCLASKNVKAEIPLNEQTTLSKENYLFTRGQTFDEKTLARDLIQAAQKQMAHAVRGKAIRSSPELFSSTVLPLPADSPTHQPLLLPPLQTPKLYGSPTQIGPSYRGMINVSTSSDMDHNSAVPGSQVSSNVGDVMSFSVTVTTIPASQAMNPSSHGQTIPVQAFSEENSIEGTPSKCYCRLKAMIMCKGCGAFCHDDCIGPSKLCVSCLVVR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
48	Phosphorylation	EGLKEIRSGTSPLAC HCHHHHHCCCCHHHH	52.68	27080861
50	Phosphorylation	LKEIRSGTSPLACLN HHHHHCCCCHHHHHH	28.55	27080861
51	Phosphorylation	KEIRSGTSPLACLNA HHHHCCCCHHHHHHH	22.80	25159151
62	Phosphorylation	CLNAMLHTNSRGEEG HHHHHHHCCCCCCCC	30.81	-
64	Phosphorylation	NAMLHTNSRGEEGIF HHHHHCCCCCCCCCE	42.70	-
95	Phosphorylation	PDGVKELSEGSEESS CCHHHHHCCCCCCCC	40.79	-
98	Phosphorylation	VKELSEGSEESSDGQ HHHHCCCCCCCCCCC	33.85	-
102	Phosphorylation	SEGSEESSDGQSDSQ CCCCCCCCCCCCCCC	49.38	30576142
102	Ubiquitination	SEGSEESSDGQSDSQ CCCCCCCCCCCCCCC	49.38	23503661
104	Ubiquitination	GSEESSDGQSDSQSS CCCCCCCCCCCCCCC	30.73	23000965
105	Neddylation	SEESSDGQSDSQSSE CCCCCCCCCCCCCCC	49.40	32015554
105	Ubiquitination	SEESSDGQSDSQSSE CCCCCCCCCCCCCCC	49.40	23000965
105 (in isoform 2)	Ubiquitination	-	49.40	21890473
110	Neddylation	DGQSDSQSSENSSSS CCCCCCCCCCCCCCC	43.50	32015554
110	Ubiquitination	DGQSDSQSSENSSSS CCCCCCCCCCCCCCC	43.50	23000965
110 (in isoform 2)	Ubiquitination	-	43.50	21890473
117	Phosphorylation	SSENSSSSSDGGSNK CCCCCCCCCCCCCCC	34.10	30576142
122	Phosphorylation	SSSSDGGSNKEGKKS CCCCCCCCCCCCCHH	50.70	30576142
136	Phosphorylation	SRWKRKVSSSSPQSG HHHHCCCCCCCCCCC	27.77	30266825
137	Phosphorylation	RWKRKVSSSSPQSGC HHHCCCCCCCCCCCC	37.51	30266825
138	Phosphorylation	WKRKVSSSSPQSGCP HHCCCCCCCCCCCCC	38.23	30266825
139	Phosphorylation	KRKVSSSSPQSGCPS HCCCCCCCCCCCCCC	28.98	30266825
142	Phosphorylation	VSSSSPQSGCPSPTI CCCCCCCCCCCCCCC	45.83	30266825
146	Phosphorylation	SPQSGCPSPTIPAGK CCCCCCCCCCCCCCC	38.46	30266825
148	Phosphorylation	QSGCPSPTIPAGKVI CCCCCCCCCCCCCCC	43.88	30266825
156	Phosphorylation	IPAGKVISPSQKHSK CCCCCCCCCCHHHHH	22.83	26657352
158	Phosphorylation	AGKVISPSQKHSKKA CCCCCCCCHHHHHHH	45.10	30266825
163	Acetylation	SPSQKHSKKALKQAL CCCHHHHHHHHHHHH	41.61	12655617
167	Acetylation	KHSKKALKQALKQQQ HHHHHHHHHHHHHHH	38.08	12655625
195	Phosphorylation	ISSNQHLSLKTVKAA CCCCCCEEECEEHHH	26.20	24719451
209	Acetylation	ASDSVPAKPATWEGK HCCCCCCCCCCCCCC	29.17	26051181
218	Phosphorylation	ATWEGKQSDGQTGSP CCCCCCCCCCCCCCC	47.39	28450419
222	Phosphorylation	GKQSDGQTGSPQNSN CCCCCCCCCCCCCCC	45.19	28450419
224	Phosphorylation	QSDGQTGSPQNSNSS CCCCCCCCCCCCCCC	27.05	25159151
228	Phosphorylation	QTGSPQNSNSSFSSS CCCCCCCCCCCCCCC	32.61	28450419
230	Phosphorylation	GSPQNSNSSFSSSVK CCCCCCCCCCCCCEE	32.36	23186163
231	Phosphorylation	SPQNSNSSFSSSVKV CCCCCCCCCCCCEEE	33.14	23186163
233	Phosphorylation	QNSNSSFSSSVKVEN CCCCCCCCCCEEEEE	24.53	23186163
240	Ubiquitination	SSSVKVENTLLGLGK CCCEEEEECCHHCCH	38.73	23503661
242	Ubiquitination	SVKVENTLLGLGKKS CEEEEECCHHCCHHH	5.57	23000965
243	Ubiquitination	VKVENTLLGLGKKSF EEEEECCHHCCHHHH	5.11	23000965
247	Acetylation	NTLLGLGKKSFQRSE ECCHHCCHHHHHHHH	50.73	25953088
248	Ubiquitination	TLLGLGKKSFQRSER CCHHCCHHHHHHHHH	55.49	23000965
258	Phosphorylation	QRSERLHTRQMKRTK HHHHHHHHHHHHCCC	27.47	24719451
289	Ubiquitination	NLRALINKHTFSVLP CHHHHHHHCCCCCCC	36.71	29967540
304	Ubiquitination	GDCQQRLLLLLPEVD CCHHHHHHHHCHHHC	3.27	23503661
306	Ubiquitination	CQQRLLLLLPEVDRQ HHHHHHHHCHHHCCC	8.27	23000965
307	Neddylation	QQRLLLLLPEVDRQV HHHHHHHCHHHCCCC	3.24	32015554
307	Ubiquitination	QQRLLLLLPEVDRQV HHHHHHHCHHHCCCC	3.24	23000965
312	Neddylation	LLLPEVDRQVGPDGL HHCHHHCCCCCCCCH	37.96	32015554
312	Ubiquitination	LLLPEVDRQVGPDGL HHCHHHCCCCCCCCH	37.96	23000965
334	Ubiquitination	LNNEFFTSAAQGWKE HCCHHHHHHHHHHHH	19.22	23503661
336	Ubiquitination	NEFFTSAAQGWKERL CHHHHHHHHHHHHHH	14.26	23000965
337	Ubiquitination	EFFTSAAQGWKERLS HHHHHHHHHHHHHHC	58.98	23000965
342	Ubiquitination	AAQGWKERLSEGEFT HHHHHHHHHCCCCCC	39.52	23000965
361	Ubiquitination	VRIRQEIEKEKKVEP HHHHHHHHHHCCCCH	55.18	23503661
362	Ubiquitination	RIRQEIEKEKKVEPW HHHHHHHHHCCCCHH	79.20	23503661
363	Ubiquitination	IRQEIEKEKKVEPWK HHHHHHHHCCCCHHH	45.37	23000965
364	Ubiquitination	RQEIEKEKKVEPWKE HHHHHHHCCCCHHHH	73.51	23000965
365	Neddylation	QEIEKEKKVEPWKEQ HHHHHHCCCCHHHHH	53.58	32015554
365	Ubiquitination	QEIEKEKKVEPWKEQ HHHHHHCCCCHHHHH	53.58	23000965
365 (in isoform 1)	Ubiquitination	-	53.58	21890473
369	Ubiquitination	KEKKVEPWKEQFFES HHCCCCHHHHHHHHH	11.87	23000965
370	Neddylation	EKKVEPWKEQFFESY HCCCCHHHHHHHHHH	52.97	32015554
370	Ubiquitination	EKKVEPWKEQFFESY HCCCCHHHHHHHHHH	52.97	23000965
370 (in isoform 1)	Ubiquitination	-	52.97	21890473
376	Phosphorylation	WKEQFFESYYGQSSG HHHHHHHHHHCCCCC	20.64	-
393	Phosphorylation	LEDSKKLTASPSDPK HHHHCCCCCCCCCCC	33.69	30266825
395	Phosphorylation	DSKKLTASPSDPKVK HHCCCCCCCCCCCCC	21.50	23401153
397	Phosphorylation	KKLTASPSDPKVKKT CCCCCCCCCCCCCCC	65.14	30266825
411	O-linked_Glycosylation	TPAEQPKSMPVSEAS CCCCCCCCCCCCHHH	34.69	30059200
411	Phosphorylation	TPAEQPKSMPVSEAS CCCCCCCCCCCCHHH	34.69	28555341
415	O-linked_Glycosylation	QPKSMPVSEASLIRI CCCCCCCCHHHHEEE	22.90	30059200
415	Phosphorylation	QPKSMPVSEASLIRI CCCCCCCCHHHHEEE	22.90	22210691
429	Phosphorylation	IVPVVSQSECKEEAL EEEEECHHHHHHHHH	37.14	22210691
439	Phosphorylation	KEEALQMSSPGRKEE HHHHHHCCCCCCHHH	22.03	25849741
440	Phosphorylation	EEALQMSSPGRKEEC HHHHHCCCCCCHHHH	26.49	29255136
449	Phosphorylation	GRKEECESQGEVQPN CCHHHHHCCCCCCCC	55.96	27251275
515	Phosphorylation	TASNYNKSESQESLV CCCCCCCCCCCHHCC	38.55	30266825
517	Phosphorylation	SNYNKSESQESLVTS CCCCCCCCCHHCCCC	46.46	17525332
520	Phosphorylation	NKSESQESLVTSPSK CCCCCCHHCCCCCCC	22.09	30266825
523	Phosphorylation	ESQESLVTSPSKPKS CCCHHCCCCCCCCCC	39.97	30266825
524	Phosphorylation	SQESLVTSPSKPKSP CCHHCCCCCCCCCCC	21.50	30266825
526	Phosphorylation	ESLVTSPSKPKSPGV HHCCCCCCCCCCCCC	62.45	30266825
530	Phosphorylation	TSPSKPKSPGVEKPI CCCCCCCCCCCCCCC	35.10	29255136
541	Phosphorylation	EKPIVKPTAGAGPQE CCCCCCCCCCCCCCC	31.82	23927012
549	Phosphorylation	AGAGPQETNMKEPLA CCCCCCCCCCCCCHH	35.05	27251275
557	Phosphorylation	NMKEPLATLVDQSPE CCCCCHHHHHCCCHH	34.69	25850435
562	Phosphorylation	LATLVDQSPESLKRK HHHHHCCCHHHHHHH	26.60	19664994
565	Phosphorylation	LVDQSPESLKRKSSL HHCCCHHHHHHHCCC	42.44	30266825
570	Phosphorylation	PESLKRKSSLTQEEA HHHHHHHCCCCCCCC	34.31	23401153
571	Phosphorylation	ESLKRKSSLTQEEAP HHHHHHCCCCCCCCC	38.17	23401153
573	Phosphorylation	LKRKSSLTQEEAPVS HHHHCCCCCCCCCCC	35.56	30266825
574	Phosphorylation	KRKSSLTQEEAPVSW HHHCCCCCCCCCCCH	52.40	33259812
580	Phosphorylation	TQEEAPVSWEKRPRV CCCCCCCCHHHCCCC	28.58	25159151
600	Phosphorylation	HQQPFQVSPQPFLNR CCCCCCCCCCCCCCC	13.66	30266825
627	Phosphorylation	KIPVSRISPMPFHPS CCCCCCCCCCCCCHH	17.65	29978859
634	Phosphorylation	SPMPFHPSQVSPRAR CCCCCCHHHCCCCCC	34.34	28450419
637	Phosphorylation	PFHPSQVSPRARFPV CCCHHHCCCCCCCCE	10.88	25159151
639	Methylation	HPSQVSPRARFPVSI CHHHCCCCCCCCEEC	30.78	-
641	Asymmetric dimethylarginine	SQVSPRARFPVSITS HHCCCCCCCCEECCC	37.37	-
641	Methylation	SQVSPRARFPVSITS HHCCCCCCCCEECCC	37.37	-
645	Phosphorylation	PRARFPVSITSPNRT CCCCCCEECCCCCCC	22.01	28122231
647	Phosphorylation	ARFPVSITSPNRTGA CCCCEECCCCCCCCC	30.53	25159151
648	Phosphorylation	RFPVSITSPNRTGAR CCCEECCCCCCCCCC	20.64	25159151
652	Phosphorylation	SITSPNRTGARTLAD ECCCCCCCCCCCHHH	41.66	23322592
709	Phosphorylation	GEGGEGQTARGGSPG CCCCCCCCCCCCCCC	29.22	22210691
714	Phosphorylation	GQTARGGSPGSDRVS CCCCCCCCCCCCCCC	28.98	23401153
717	Phosphorylation	ARGGSPGSDRVSETG CCCCCCCCCCCCCCC	26.15	24732914
721	Phosphorylation	SPGSDRVSETGKGPT CCCCCCCCCCCCCCC	30.27	24732914
723	Phosphorylation	GSDRVSETGKGPTLE CCCCCCCCCCCCCEE	36.37	24732914
725	Acetylation	DRVSETGKGPTLELA CCCCCCCCCCCEEEC	69.96	26051181
728	Phosphorylation	SETGKGPTLELAGTG CCCCCCCCEEECCCC	41.34	24732914
728 (in isoform 2)	Ubiquitination	-	41.34	21890473
776	Phosphorylation	SGAQLQQTPPVPPTP CCCCCCCCCCCCCCC	19.32	33259812
794	Phosphorylation	GACTSVPSPAHIEKL CCCCCCCCHHHHHHH	32.34	28348404
812	Phosphorylation	KLNPTRATATVASVS CCCCCCCEEEEEEEC	21.41	23312004
814	Phosphorylation	NPTRATATVASVSHP CCCCCEEEEEEECCC	16.55	23312004
817	Phosphorylation	RATATVASVSHPQGP CCEEEEEEECCCCCC	21.59	23312004
819	Phosphorylation	TATVASVSHPQGPSS EEEEEEECCCCCCCC	27.27	23312004
825	Phosphorylation	VSHPQGPSSCRQEKA ECCCCCCCCCCCCCC	49.23	23312004
826	Phosphorylation	SHPQGPSSCRQEKAP CCCCCCCCCCCCCCC	19.22	23312004
834	Phosphorylation	CRQEKAPSPTGPALI CCCCCCCCCCCCCCC	39.70	29255136
836	Phosphorylation	QEKAPSPTGPALISG CCCCCCCCCCCCCCC	61.20	29255136
842	Phosphorylation	PTGPALISGASPVHC CCCCCCCCCCCCCEE	29.20	30266825
845	Phosphorylation	PALISGASPVHCAAD CCCCCCCCCCEECCC	30.86	29255136
854	Phosphorylation	VHCAADGTVELKAGP CEECCCCCEEEEECC	16.03	29255136
862	Phosphorylation	VELKAGPSKNIPNPS EEEEECCCCCCCCCC	37.10	24505115
883	Phosphorylation	ASVPVAVTPSPLTSL CCCCEEECCCCHHHH	14.33	27251275
885	Phosphorylation	VPVAVTPSPLTSLLT CCEEECCCCHHHHHH	24.15	27251275
888	Phosphorylation	AVTPSPLTSLLTTAT EECCCCHHHHHHHHC	22.25	27251275
889	Phosphorylation	VTPSPLTSLLTTATL ECCCCHHHHHHHHCH	29.12	27251275
895	Phosphorylation	TSLLTTATLEKLPVP HHHHHHHCHHCCCCC	33.10	24719451
973	Phosphorylation	QILPKPLTKVEMKTV HCCCCCCCEEEEEEC	41.38	29449344
983	Phosphorylation	EMKTVPLTAKEERGM EEEECCCCCCHHHCC	29.61	22210691
996	Phosphorylation	GMGALIATNTTENST CCEEEEEECCCCCCC	26.55	24719451
1002	Phosphorylation	ATNTTENSTREEVNE EECCCCCCCHHHHHH	23.70	22210691
1003	Phosphorylation	TNTTENSTREEVNER ECCCCCCCHHHHHHH	54.40	22210691
1022	Acetylation	ATQQQLGKTLQSKQL HHHHHHHHHHHHCCC	55.44	25953088
1042	Acetylation	PLQLFSAKELRDSSI CHHEEEHHHHHHCCC	56.96	26051181
1047	Phosphorylation	SAKELRDSSIDTHQY EHHHHHHCCCCHHHH	23.82	28348404
1048	Phosphorylation	AKELRDSSIDTHQYH HHHHHHCCCCHHHHH	28.86	28348404
1054	Phosphorylation	SSIDTHQYHEGLSKA CCCCHHHHHHHHCHH	8.34	-
1059	Phosphorylation	HQYHEGLSKATQDQI HHHHHHHCHHHHHHH	30.97	-
1117	Acetylation	FAGRRTSKPAMAGHY HCCCCCCCCCHHCEE	35.86	26051181
1129	Phosphorylation	GHYLLNISTYGRGSE CEEEEEEECCCCCCH	17.95	23322592
1130	Phosphorylation	HYLLNISTYGRGSES EEEEEEECCCCCCHH	26.63	23322592
1141	Phosphorylation	GSESFRRTHSVNPED CCHHHCCCCCCCHHH	17.78	23403867
1143	Phosphorylation	ESFRRTHSVNPEDRF HHHCCCCCCCHHHCC	23.99	23403867
1153	Phosphorylation	PEDRFCLSSPTEALK HHHCCCCCCHHHHHH	35.14	30266825
1154	Phosphorylation	EDRFCLSSPTEALKM HHCCCCCCHHHHHHC	23.93	29255136
1156	Phosphorylation	RFCLSSPTEALKMGY CCCCCCHHHHHHCCC	35.52	30266825
1163	Phosphorylation	TEALKMGYTDCKNAT HHHHHCCCCCCCCCC	8.91	26074081
1164	Phosphorylation	EALKMGYTDCKNATG HHHHCCCCCCCCCCC	29.23	26074081
1173	Phosphorylation	CKNATGESSSSKEDD CCCCCCCCCCCCCCC	36.54	-
1174	Phosphorylation	KNATGESSSSKEDDT CCCCCCCCCCCCCCC	34.04	-
1175	Phosphorylation	NATGESSSSKEDDTD CCCCCCCCCCCCCCC	55.50	-
1181	Phosphorylation	SSSKEDDTDEESTGD CCCCCCCCCCCCCCC	58.60	25159151
1185	Phosphorylation	EDDTDEESTGDEQES CCCCCCCCCCCCCCC	35.33	24461736
1186	Phosphorylation	DDTDEESTGDEQESV CCCCCCCCCCCCCCE	52.51	24461736
1192	Phosphorylation	STGDEQESVTVKEEP CCCCCCCCEEEECCC	23.84	30576142
1194	Phosphorylation	GDEQESVTVKEEPQV CCCCCCEEEECCCCC	34.83	30576142
1202	Phosphorylation	VKEEPQVSQSAGKGD EECCCCCHHCCCCCC	17.11	30576142
1232	Sumoylation	CLASKNVKAEIPLNE HCCCCCCCEECCCCC	50.09	-
1232	Sumoylation	CLASKNVKAEIPLNE HCCCCCCCEECCCCC	50.09	-
1245	Ubiquitination	NEQTTLSKENYLFTR CCCCCCCCCCCEEEC	53.76	2190698
1245 (in isoform 1)	Ubiquitination	-	53.76	21890473
1255	Phosphorylation	YLFTRGQTFDEKTLA CEEECCCCCCHHHHH	35.56	24505115
1259	Sumoylation	RGQTFDEKTLARDLI CCCCCCHHHHHHHHH	51.16	-
1259	Sumoylation	RGQTFDEKTLARDLI CCCCCCHHHHHHHHH	51.16	-
1259	Ubiquitination	RGQTFDEKTLARDLI CCCCCCHHHHHHHHH	51.16	29967540
1260	Phosphorylation	GQTFDEKTLARDLIQ CCCCCHHHHHHHHHH	24.49	-
1271	Acetylation	DLIQAAQKQMAHAVR HHHHHHHHHHHHHHH	37.00	25953088
1271	Ubiquitination	DLIQAAQKQMAHAVR HHHHHHHHHHHHHHH	37.00	-
1284	Phosphorylation	VRGKAIRSSPELFSS HHHHHHHCCCCHHHC	44.10	25159151
1285	Phosphorylation	RGKAIRSSPELFSST HHHHHHCCCCHHHCC	16.73	29116813
1290	Phosphorylation	RSSPELFSSTVLPLP HCCCCHHHCCEEECC	37.41	20873877
1291	Phosphorylation	SSPELFSSTVLPLPA CCCCHHHCCEEECCC	18.39	26657352
1292	Phosphorylation	SPELFSSTVLPLPAD CCCHHHCCEEECCCC	25.51	20873877
1300	Phosphorylation	VLPLPADSPTHQPLL EEECCCCCCCCCCCC	33.53	26657352
1302	Phosphorylation	PLPADSPTHQPLLLP ECCCCCCCCCCCCCC	36.78	29116813
1313	Phosphorylation	LLLPPLQTPKLYGSP CCCCCCCCCCCCCCC	30.03	20873877
1315	Sumoylation	LPPLQTPKLYGSPTQ CCCCCCCCCCCCCCC	58.70	-
1317	Phosphorylation	PLQTPKLYGSPTQIG CCCCCCCCCCCCCCC	22.99	23403867
1319	Phosphorylation	QTPKLYGSPTQIGPS CCCCCCCCCCCCCCC	15.95	25159151
1321	Phosphorylation	PKLYGSPTQIGPSYR CCCCCCCCCCCCCCC	34.22	20068231
1326	Phosphorylation	SPTQIGPSYRGMINV CCCCCCCCCCCCEEE	23.42	23312004
1327	Phosphorylation	PTQIGPSYRGMINVS CCCCCCCCCCCEEEC	17.83	23403867
1426	Acetylation	DDCIGPSKLCVSCLV CCCCCHHHCEEEEEE	49.38	26051181
1430	Phosphorylation	GPSKLCVSCLVVR-- CHHHCEEEEEEEC--	10.75	20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ASXL2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ASXL2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ASXL2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
KDM1B_HUMAN	KDM1B	physical	26186194
MBD6_HUMAN	MBD6	physical	26186194
BAP1_HUMAN	BAP1	physical	26186194
FOXK1_HUMAN	FOXK1	physical	26186194
MBD5_HUMAN	MBD5	physical	26186194
BAP1_HUMAN	BAP1	physical	26416890
OGT1_HUMAN	OGT	physical	26416890
HCFC1_HUMAN	HCFC1	physical	26416890
FOXK1_HUMAN	FOXK1	physical	26416890
FOXK2_HUMAN	FOXK2	physical	26416890
MBD5_HUMAN	MBD5	physical	28514442
KDM1B_HUMAN	KDM1B	physical	28514442
BAP1_HUMAN	BAP1	physical	28514442
MBD6_HUMAN	MBD6	physical	28514442
FOXK1_HUMAN	FOXK1	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ASXL2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-139; SER-142; SER-146;SER-224 AND SER-562, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-137; SER-139 ANDSER-146, AND MASS SPECTROMETRY.	18669648 [Abstract]
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