NLRC3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NLRC3_HUMAN
• UniProt AC: Q7RTR2
• Protein Name: NLR family CARD domain-containing protein 3
• Gene Name: NLRC3
• Organism: Homo sapiens (Human).
• Sequence Length: 1065
• Subcellular Localization: Cytoplasm .
• Protein Description: Negative regulator of the innate immune response. [PubMed: 15705585]
• Protein Sequence: MRKQEVRTGREAGQGHGTGSPAEQVKALMDLLAGKGSQGSQAPQALDRTPDAPLGPCSNDSRIQRHRKALLSKVGGGPELGGPWHRLASLLLVEGLTDLQLREHDFTQVEATRGGGHPARTVALDRLFLPLSRVSVPPRVSITIGVAGMGKTTLVRHFVRLWAHGQVGKDFSLVLPLTFRDLNTHEKLCADRLICSVFPHVGEPSLAVAVPARALLILDGLDECRTPLDFSNTVACTDPKKEIPVDHLITNIIRGNLFPEVSIWITSRPSASGQIPGGLVDRMTEIRGFNEEEIKVCLEQMFPEDQALLGWMLSQVQADRALYLMCTVPAFCRLTGMALGHLWRSRTGPQDAELWPPRTLCELYSWYFRMALSGEGQEKGKASPRIEQVAHGGRKMVGTLGRLAFHGLLKKKYVFYEQDMKAFGVDLALLQGAPCSCFLQREETLASSVAYCFTHLSLQEFVAAAYYYGASRRAIFDLFTESGVSWPRLGFLTHFRSAAQRAMQAEDGRLDVFLRFLSGLLSPRVNALLAGSLLAQGEHQAYRTQVAELLQGCLRPDAAVCARAINVLHCLHELQHTELARSVEEAMESGALARLTGPAHRAALAYLLQVSDACAQEANLSLSLSQGVLQSLLPQLLYCRKLRLDTNQFQDPVMELLGSVLSGKDCRIQKISLAENQISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALADALKINRTLTSLSLQGNTVRDDGARSMAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQNRSLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVRENRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALKVNTALTALYLQVASIGASGAQVLGEALAVNRTLEILDLRGNAIGVAGAKALANALKVNSSLRRLNLQENSLGMDGAICIATALSGNHRLQHINLQGNHIGDSGARMISEAIKTNAPTCTVEM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18 (in isoform 2)	Phosphorylation	-	28.89	24043423
18	Phosphorylation	EAGQGHGTGSPAEQV CCCCCCCCCCHHHHH	28.89	23401153
20	Phosphorylation	GQGHGTGSPAEQVKA CCCCCCCCHHHHHHH	22.30	30576142
26	Ubiquitination	GSPAEQVKALMDLLA CCHHHHHHHHHHHHC	35.18	-
35	Ubiquitination	LMDLLAGKGSQGSQA HHHHHCCCCCCCCCC	50.19	-
49	Phosphorylation	APQALDRTPDAPLGP CCHHHCCCCCCCCCC	25.78	-
58	Phosphorylation	DAPLGPCSNDSRIQR CCCCCCCCCCHHHHH	46.97	29978859
61	Phosphorylation	LGPCSNDSRIQRHRK CCCCCCCHHHHHHHH	35.22	29978859
72	Phosphorylation	RHRKALLSKVGGGPE HHHHHHHHHHCCCCC	26.58	-
73	Ubiquitination	HRKALLSKVGGGPEL HHHHHHHHHCCCCCC	44.89	-
135	Phosphorylation	FLPLSRVSVPPRVSI ECCHHHCCCCCEEEE	28.00	23312004
187	Ubiquitination	RDLNTHEKLCADRLI CCCCHHHHHHHHHHH	41.06	-
240	Ubiquitination	TVACTDPKKEIPVDH CCEECCCCCCCCCCH	66.89	-
241	Ubiquitination	VACTDPKKEIPVDHL CEECCCCCCCCCCHH	67.28	-
379	Ubiquitination	LSGEGQEKGKASPRI HCCCCCCCCCCCCHH	58.80	-
416	Phosphorylation	LKKKYVFYEQDMKAF HHCCEEEEHHHHHHH	11.57	-
485	Phosphorylation	LFTESGVSWPRLGFL HHHCCCCCCCHHHHH	34.58	24719451
522	Phosphorylation	RFLSGLLSPRVNALL HHHHHHCCHHHHHHH	18.72	24719451
670	Ubiquitination	GKDCRIQKISLAENQ CCCCEEEECCCHHHC	31.71	-
681	Ubiquitination	AENQISNKGAKALAR HHHCCCHHHHHHHHH	54.15	-
697	Phosphorylation	LLVNRSLTSLDLRGN HHHCCCCCHHCCCCC	28.61	26437602
698	Phosphorylation	LVNRSLTSLDLRGNS HHCCCCCHHCCCCCC	25.77	24719451
716 (in isoform 2)	Ubiquitination	-	53.97	-
725	Phosphorylation	LKINRTLTSLSLQGN HHHCCCCCHHHCCCC	27.32	24114839
751	Phosphorylation	EALASNRTLSMLHLQ HHHHHCCCEEHHHHC	27.69	-
753	Phosphorylation	LASNRTLSMLHLQKN HHHCCCEEHHHHCCC	20.77	-
759	Ubiquitination	LSMLHLQKNSIGPMG EEHHHHCCCCCCHHH	60.05	-
775	Ubiquitination	QRMADALKQNRSLKE HHHHHHHHHCCCHHH	47.44	-
781	Ubiquitination	LKQNRSLKELMFSSN HHHCCCHHHHHHCCC	50.47	-
789	Phosphorylation	ELMFSSNSIGDGGAK HHHHCCCCCCCHHHH	29.87	28634298
838	Phosphorylation	CTNQTLLSLSLRENS HCCCHHHHHHHCCCC	21.01	17081983
840	Phosphorylation	NQTLLSLSLRENSIS CCHHHHHHHCCCCCC	23.23	17081983
845	Phosphorylation	SLSLRENSISPEGAQ HHHHCCCCCCHHHHH	21.49	30177828
847	Phosphorylation	SLRENSISPEGAQAI HHCCCCCCHHHHHHH	19.40	30177828
862	Phosphorylation	AHALCANSTLKNLDL HHHHHHCCHHCCCHH	19.32	30177828
863	Phosphorylation	HALCANSTLKNLDLT HHHHHCCHHCCCHHH	41.37	30177828
992	Sumoylation	AIGVAGAKALANALK CCHHHHHHHHHHHHH	42.91	-
992	Sumoylation	AIGVAGAKALANALK CCHHHHHHHHHHHHH	42.91	-
1055	Ubiquitination	RMISEAIKTNAPTCT HHHHHHHHHCCCCCE	42.65	-
1062	Phosphorylation	KTNAPTCTVEM---- HHCCCCCEECC----	23.21	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NLRC3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NLRC3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NLRC3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of NLRC3_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.