SIGIR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SIGIR_HUMAN
• UniProt AC: Q6IA17
• Protein Name: Single Ig IL-1-related receptor
• Gene Name: SIGIRR
• Organism: Homo sapiens (Human).
• Sequence Length: 410
• Subcellular Localization: Membrane ; Single-pass type III membrane protein .
• Protein Description: Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP..
• Protein Sequence: MPGVCDRAPDFLSPSEDQVLRPALGSSVALNCTAWVVSGPHCSLPSVQWLKDGLPLGIGGHYSLHEYSWVKANLSEVLVSSVLGVNVTSTEVYGAFTCSIQNISFSSFTLQRAGPTSHVAAVLASLLVLLALLLAALLYVKCRLNVLLWYQDAYGEVEINDGKLYDAYVSYSDCPEDRKFVNFILKPQLERRRGYKLFLDDRDLLPRAEPSADLLVNLSRCRRLIVVLSDAFLSRAWCSHSFREGLCRLLELTRRPIFITFEGQRRDPAHPALRLLRQHRHLVTLLLWRPGSVTPSSDFWKEVQLALPRKVQYRPVEGDPQTQLQDDKDPMLILRGRVPEGRALDSEVDPDPEGDLGVRGPVFGEPSAPPHTSGVSLGESRSSEVDVSDLGSRNYSARTDFYCLVSKDDM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	N-linked_Glycosylation	LGSSVALNCTAWVVS CCCCEECCCEEEEEE	16.03	UniProtKB CARBOHYD
67	Phosphorylation	GHYSLHEYSWVKANL CCCCHHHCCCHHCCH	9.33	22468782
73	N-linked_Glycosylation	EYSWVKANLSEVLVS HCCCHHCCHHHHHHH	38.08	UniProtKB CARBOHYD
75	Phosphorylation	SWVKANLSEVLVSSV CCHHCCHHHHHHHHH	26.01	22468782
86	N-linked_Glycosylation	VSSVLGVNVTSTEVY HHHHHCCCCCCCEEE	29.56	UniProtKB CARBOHYD
102	N-linked_Glycosylation	AFTCSIQNISFSSFT EEEEEEEEEEEEEEE	30.15	UniProtKB CARBOHYD
165	Phosphorylation	EINDGKLYDAYVSYS EECCCEEEEEEEECC	11.30	23401153
168	Phosphorylation	DGKLYDAYVSYSDCP CCEEEEEEEECCCCC	6.24	23401153
170	Phosphorylation	KLYDAYVSYSDCPED EEEEEEEECCCCCCC	13.27	23401153
171	Phosphorylation	LYDAYVSYSDCPEDR EEEEEEECCCCCCCC	9.85	23401153
172	Phosphorylation	YDAYVSYSDCPEDRK EEEEEECCCCCCCCC	25.82	23401153
179	Ubiquitination	SDCPEDRKFVNFILK CCCCCCCCHHHHHHH	67.02	-
186	Ubiquitination	KFVNFILKPQLERRR CHHHHHHHHHHHHHC	26.38	-
196 (in isoform 2)	Ubiquitination	-	35.27	21890473
196 (in isoform 1)	Ubiquitination	-	35.27	21890473
196	Ubiquitination	LERRRGYKLFLDDRD HHHHCCCEEEECCHH	35.27	2189047
211	Phosphorylation	LLPRAEPSADLLVNL CCCCCCCCHHHHHHH	26.39	-
219	Phosphorylation	ADLLVNLSRCRRLIV HHHHHHHHHHHHHHH	24.91	-
239	Phosphorylation	FLSRAWCSHSFREGL HHHHHHCCCHHHHHH	16.09	26552605
241	Phosphorylation	SRAWCSHSFREGLCR HHHHCCCHHHHHHHH	15.09	26552605
253	Phosphorylation	LCRLLELTRRPIFIT HHHHHHHHCCCEEEE	18.43	27542207
328	Ubiquitination	QTQLQDDKDPMLILR CCCCCCCCCCEEEEE	72.52	-
346 (in isoform 2)	Phosphorylation	-	40.13	28111955
346	Phosphorylation	PEGRALDSEVDPDPE CCCCCCCCCCCCCCC	40.13	28188228
364 (in isoform 2)	Phosphorylation	-	46.25	25849741
366 (in isoform 2)	Phosphorylation	-	35.85	28450419
367	Phosphorylation	GPVFGEPSAPPHTSG CCCCCCCCCCCCCCC	49.45	23312004
372	Phosphorylation	EPSAPPHTSGVSLGE CCCCCCCCCCCCCCC	32.71	26074081
373	Phosphorylation	PSAPPHTSGVSLGES CCCCCCCCCCCCCCC	33.88	26074081
376	Phosphorylation	PPHTSGVSLGESRSS CCCCCCCCCCCCCCC	33.89	26074081
380	Phosphorylation	SGVSLGESRSSEVDV CCCCCCCCCCCCCCH	35.35	30576142
382	Phosphorylation	VSLGESRSSEVDVSD CCCCCCCCCCCCHHH	39.88	25849741
383	Phosphorylation	SLGESRSSEVDVSDL CCCCCCCCCCCHHHC	40.29	23911959
388	Phosphorylation	RSSEVDVSDLGSRNY CCCCCCHHHCCCCCC	23.74	28060719
392	Phosphorylation	VDVSDLGSRNYSART CCHHHCCCCCCCCCC	25.34	28060719
395	Phosphorylation	SDLGSRNYSARTDFY HHCCCCCCCCCCCEE	11.55	23312004
396	Phosphorylation	DLGSRNYSARTDFYC HCCCCCCCCCCCEEE	18.15	23312004
399	Phosphorylation	SRNYSARTDFYCLVS CCCCCCCCCEEEEEE	30.12	26552605
402	Phosphorylation	YSARTDFYCLVSKDD CCCCCCEEEEEECCC	6.41	28796482
406	Phosphorylation	TDFYCLVSKDDM--- CCEEEEEECCCC---	19.88	28985074
464 (in isoform 2)	Phosphorylation	-		23663014
465 (in isoform 2)	Phosphorylation	-		23663014
466 (in isoform 2)	Phosphorylation	-		23663014

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SIGIR_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SIGIR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SIGIR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SIGIR_HUMAN	SIGIRR	physical	12925853
IRAK1_HUMAN	IRAK1	physical	12925853
TRAF6_HUMAN	TRAF6	physical	12925853
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.