| UniProt ID | KI2L4_HUMAN | |
|---|---|---|
| UniProt AC | Q99706 | |
| Protein Name | Killer cell immunoglobulin-like receptor 2DL4 | |
| Gene Name | KIR2DL4 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 377 | |
| Subcellular Localization |
Cell membrane Single-pass type I membrane protein. |
|
| Protein Description | Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis.. | |
| Protein Sequence | MSMSPTVIILACLGFFLDQSVWAHVGGQDKPFCSAWPSAVVPQGGHVTLRCHYRRGFNIFTLYKKDGVPVPELYNRIFWNSFLISPVTPAHAGTYRCRGFHPHSPTEWSAPSNPLVIMVTGLYEKPSLTARPGPTVRAGENVTLSCSSQSSFDIYHLSREGEAHELRLPAVPSINGTFQADFPLGPATHGETYRCFGSFHGSPYEWSDPSDPLPVSVTGNPSSSWPSPTEPSFKTGIARHLHAVIRYSVAIILFTILPFFLLHRWCSKKKDAAVMNQEPAGHRTVNREDSDEQDPQEVTYAQLDHCIFTQRKITGPSQRSKRPSTDTSVCIELPNAEPRALSPAHEHHSQALMGSSRETTALSQTQLASSNVPAAGI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 74 | Phosphorylation | GVPVPELYNRIFWNS CCCCHHHHHHHHHHC | 10.75 | - | |
| 120 | Phosphorylation | NPLVIMVTGLYEKPS CCEEEEEEECCCCCC | 12.23 | 24719451 | |
| 123 | Phosphorylation | VIMVTGLYEKPSLTA EEEEEECCCCCCCCC | 24.21 | 27251275 | |
| 141 | N-linked_Glycosylation | PTVRAGENVTLSCSS CEEECCCCEEEEECC | 31.02 | UniProtKB CARBOHYD | |
| 175 | N-linked_Glycosylation | LPAVPSINGTFQADF CCCCCCCCCEEEECC | 48.03 | UniProtKB CARBOHYD | |
| 235 (in isoform 3) | Phosphorylation | - | 31.63 | - | |
| 355 | Phosphorylation | HSQALMGSSRETTAL HHHHHCCCCCCCHHC | 16.56 | - | |
| 356 | Phosphorylation | SQALMGSSRETTALS HHHHCCCCCCCHHCC | 28.54 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KI2L4_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KI2L4_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KI2L4_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| HLAG_HUMAN | HLA-G | physical | 10190900 | |
| RN216_HUMAN | RNF216 | physical | 21270397 | |
| TRAF6_HUMAN | TRAF6 | physical | 24337384 | |
| TRIP6_HUMAN | TRIP6 | physical | 25416956 | |
| RBPMS_HUMAN | RBPMS | physical | 25416956 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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