OTU7A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: OTU7A_HUMAN
• UniProt AC: Q8TE49
• Protein Name: OTU domain-containing protein 7A
• Gene Name: OTUD7A
• Organism: Homo sapiens (Human).
• Sequence Length: 926
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: Has deubiquitinating activity towards 'Lys-11'-linked polyubiquitin chains..
• Protein Sequence: MVSSVLPNPTSAECWAALLHDPMTLDMDAVLSDFVRSTGAEPGLARDLLEGKNWDLTAALSDYEQLRQVHTANLPHVFNEGRGPKQPEREPQPGHKVERPCLQRQDDIAQEKRLSRGISHASSAIVSLARSHVASECNNEQFPLEMPIYTFQLPDLSVYSEDFRSFIERDLIEQATMVALEQAGRLNWWSTVCTSCKRLLPLATTGDGNCLLHAASLGMWGFHDRDLVLRKALYTMMRTGAEREALKRRWRWQQTQQNKEEEWEREWTELLKLASSEPRTHFSKNGGTGGGVDNSEDPVYESLEEFHVFVLAHILRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVPPNRCHCSPLVLAYDQAHFSALVSMEQRDQQREQAVIPLTDSEHKLLPLHFAVDPGKDWEWGKDDNDNARLAHLILSLEAKLNLLHSYMNVTWIRIPSETRAPLAQPESPTASAGEDVQSLADSLDSDRDSVCSNSNSNNGKNGKDKEKEKQRKEKDKTRADSVANKLGSFSKTLGIKLKKNMGGLGGLVHGKMGRANSANGKNGDSAERGKEKKAKSRKGSKEESGASASTSPSEKTTPSPTDKAAGASPAEKGGGPRGDAWKYSTDVKLSLNILRAAMQGERKFIFAGLLLTSHRHQFHEEMIGYYLTSAQERFSAEQEQRRRDAATAAAAAAAAAAATAKRPPRRPETEGVPVPERASPGPPTQLVLKLKERPSPGPAAGRAARAAAGGTASPGGGARRASASGPVPGRSPPAPARQSVIHVQASGARDEACAPAVGALRPCATYPQQNRSLSSQSYSPARAAALRTVNTVESLARAVPGALPGAAGTAGAAEHKSQTYTNGFGALRDGLEFADADAPTARSNGECGRGGPGPVQRRCQRENCAFYGRAETEHYCSYCYREELRRRREARGARP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Phosphorylation	ALLHDPMTLDMDAVL HHHCCCCCCCHHHHH	25.62	26714015
32	Phosphorylation	LDMDAVLSDFVRSTG CCHHHHHHHHHHHHC	23.54	26714015
63	Phosphorylation	LTAALSDYEQLRQVH HHHHCCCHHHHHHHH	11.38	24114839
119	Phosphorylation	KRLSRGISHASSAIV HHHHHHHCHHHHHHH	18.80	28188228
122	Phosphorylation	SRGISHASSAIVSLA HHHHCHHHHHHHHHH	18.19	23403867
123	Phosphorylation	RGISHASSAIVSLAR HHHCHHHHHHHHHHH	23.85	23403867
127	Phosphorylation	HASSAIVSLARSHVA HHHHHHHHHHHHHHH	15.36	23403867
194	O-linked_Glycosylation	NWWSTVCTSCKRLLP CHHHHHHHHHHHHHC	32.59	30379171
426	Phosphorylation	RLAHLILSLEAKLNL HHHHHHHHHHHHHHH	19.71	-
441	Phosphorylation	LHSYMNVTWIRIPSE HHHHCCEEEEECCCC	15.35	-
449	Phosphorylation	WIRIPSETRAPLAQP EEECCCCCCCCCCCC	36.15	22210691
469	Phosphorylation	SAGEDVQSLADSLDS CCCHHHHHHHHHCCC	25.93	22210691
476	Phosphorylation	SLADSLDSDRDSVCS HHHHHCCCCHHHHCC	39.58	22210691
496	Acetylation	NGKNGKDKEKEKQRK CCCCCCHHHHHHHHH	74.33	7708465
512	Phosphorylation	KDKTRADSVANKLGS HHHHHHHHHHHHHHH	23.34	28176443
516	Acetylation	RADSVANKLGSFSKT HHHHHHHHHHHHHHH	44.48	25953088
519	Phosphorylation	SVANKLGSFSKTLGI HHHHHHHHHHHHHCC	36.46	24719451
522	Ubiquitination	NKLGSFSKTLGIKLK HHHHHHHHHHCCCCC	45.84	32142685
548	Phosphorylation	GKMGRANSANGKNGD HCCCCCCCCCCCCCC	23.33	18785766
575	Phosphorylation	RKGSKEESGASASTS CCCCHHHCCCCCCCC	40.53	21712546
578	Phosphorylation	SKEESGASASTSPSE CHHHCCCCCCCCCCC	26.69	21712546
580	Phosphorylation	EESGASASTSPSEKT HHCCCCCCCCCCCCC	27.24	21712546
586	Methylation	ASTSPSEKTTPSPTD CCCCCCCCCCCCCCC	63.13	-
586	"N6,N6-dimethyllysine"	ASTSPSEKTTPSPTD CCCCCCCCCCCCCCC	63.13	-
588	Phosphorylation	TSPSEKTTPSPTDKA CCCCCCCCCCCCCCC	32.60	-
603	Acetylation	AGASPAEKGGGPRGD CCCCCCCCCCCCCCC	66.03	19827655
613	Acetylation	GPRGDAWKYSTDVKL CCCCCCCCCCCHHHH	30.92	19827663
619	Acetylation	WKYSTDVKLSLNILR CCCCCHHHHHHHHHH	34.86	19827671
710	Phosphorylation	VPVPERASPGPPTQL CCCCCCCCCCCCCEE	36.29	32142685
715	Phosphorylation	RASPGPPTQLVLKLK CCCCCCCCEEEEEEC	37.35	23312004
742	Phosphorylation	ARAAAGGTASPGGGA HHHHHCCCCCCCCCC	24.04	23403867
744	Phosphorylation	AAAGGTASPGGGARR HHHCCCCCCCCCCCC	24.74	23403867
753	Phosphorylation	GGGARRASASGPVPG CCCCCCCCCCCCCCC	22.58	-
796	Phosphorylation	GALRPCATYPQQNRS CHHCCCCCCCCCCCC	42.31	28857561
797	Phosphorylation	ALRPCATYPQQNRSL HHCCCCCCCCCCCCC	4.78	28857561
806	Phosphorylation	QQNRSLSSQSYSPAR CCCCCCCCCCCCHHH	28.56	27732954
808	Phosphorylation	NRSLSSQSYSPARAA CCCCCCCCCCHHHHH	29.53	27732954
809	Phosphorylation	RSLSSQSYSPARAAA CCCCCCCCCHHHHHH	15.84	27732954
810	Phosphorylation	SLSSQSYSPARAAAL CCCCCCCCHHHHHHH	19.82	27732954
822	Phosphorylation	AALRTVNTVESLARA HHHHHHHHHHHHHHH	22.70	29978859
825	Phosphorylation	RTVNTVESLARAVPG HHHHHHHHHHHHCCC	24.00	29978859
880	Methylation	RSNGECGRGGPGPVQ CCCCCCCCCCCCHHH	59.56	58858747

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of OTU7A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of OTU7A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of OTU7A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBC_HUMAN	UBC	physical	23827681

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.