OTU7A_HUMAN - dbPTM
OTU7A_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID OTU7A_HUMAN
UniProt AC Q8TE49
Protein Name OTU domain-containing protein 7A
Gene Name OTUD7A
Organism Homo sapiens (Human).
Sequence Length 926
Subcellular Localization Cytoplasm. Nucleus.
Protein Description Has deubiquitinating activity towards 'Lys-11'-linked polyubiquitin chains..
Protein Sequence MVSSVLPNPTSAECWAALLHDPMTLDMDAVLSDFVRSTGAEPGLARDLLEGKNWDLTAALSDYEQLRQVHTANLPHVFNEGRGPKQPEREPQPGHKVERPCLQRQDDIAQEKRLSRGISHASSAIVSLARSHVASECNNEQFPLEMPIYTFQLPDLSVYSEDFRSFIERDLIEQATMVALEQAGRLNWWSTVCTSCKRLLPLATTGDGNCLLHAASLGMWGFHDRDLVLRKALYTMMRTGAEREALKRRWRWQQTQQNKEEEWEREWTELLKLASSEPRTHFSKNGGTGGGVDNSEDPVYESLEEFHVFVLAHILRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVPPNRCHCSPLVLAYDQAHFSALVSMEQRDQQREQAVIPLTDSEHKLLPLHFAVDPGKDWEWGKDDNDNARLAHLILSLEAKLNLLHSYMNVTWIRIPSETRAPLAQPESPTASAGEDVQSLADSLDSDRDSVCSNSNSNNGKNGKDKEKEKQRKEKDKTRADSVANKLGSFSKTLGIKLKKNMGGLGGLVHGKMGRANSANGKNGDSAERGKEKKAKSRKGSKEESGASASTSPSEKTTPSPTDKAAGASPAEKGGGPRGDAWKYSTDVKLSLNILRAAMQGERKFIFAGLLLTSHRHQFHEEMIGYYLTSAQERFSAEQEQRRRDAATAAAAAAAAAAATAKRPPRRPETEGVPVPERASPGPPTQLVLKLKERPSPGPAAGRAARAAAGGTASPGGGARRASASGPVPGRSPPAPARQSVIHVQASGARDEACAPAVGALRPCATYPQQNRSLSSQSYSPARAAALRTVNTVESLARAVPGALPGAAGTAGAAEHKSQTYTNGFGALRDGLEFADADAPTARSNGECGRGGPGPVQRRCQRENCAFYGRAETEHYCSYCYREELRRRREARGARP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
24PhosphorylationALLHDPMTLDMDAVL
HHHCCCCCCCHHHHH
25.6226714015
32PhosphorylationLDMDAVLSDFVRSTG
CCHHHHHHHHHHHHC
23.5426714015
63PhosphorylationLTAALSDYEQLRQVH
HHHHCCCHHHHHHHH
11.3824114839
119PhosphorylationKRLSRGISHASSAIV
HHHHHHHCHHHHHHH
18.8028188228
122PhosphorylationSRGISHASSAIVSLA
HHHHCHHHHHHHHHH
18.1923403867
123PhosphorylationRGISHASSAIVSLAR
HHHCHHHHHHHHHHH
23.8523403867
127PhosphorylationHASSAIVSLARSHVA
HHHHHHHHHHHHHHH
15.3623403867
194O-linked_GlycosylationNWWSTVCTSCKRLLP
CHHHHHHHHHHHHHC
32.5930379171
426PhosphorylationRLAHLILSLEAKLNL
HHHHHHHHHHHHHHH
19.71-
441PhosphorylationLHSYMNVTWIRIPSE
HHHHCCEEEEECCCC
15.35-
449PhosphorylationWIRIPSETRAPLAQP
EEECCCCCCCCCCCC
36.1522210691
469PhosphorylationSAGEDVQSLADSLDS
CCCHHHHHHHHHCCC
25.9322210691
476PhosphorylationSLADSLDSDRDSVCS
HHHHHCCCCHHHHCC
39.5822210691
496AcetylationNGKNGKDKEKEKQRK
CCCCCCHHHHHHHHH
74.337708465
512PhosphorylationKDKTRADSVANKLGS
HHHHHHHHHHHHHHH
23.3428176443
516AcetylationRADSVANKLGSFSKT
HHHHHHHHHHHHHHH
44.4825953088
519PhosphorylationSVANKLGSFSKTLGI
HHHHHHHHHHHHHCC
36.4624719451
522UbiquitinationNKLGSFSKTLGIKLK
HHHHHHHHHHCCCCC
45.8432142685
548PhosphorylationGKMGRANSANGKNGD
HCCCCCCCCCCCCCC
23.3318785766
575PhosphorylationRKGSKEESGASASTS
CCCCHHHCCCCCCCC
40.5321712546
578PhosphorylationSKEESGASASTSPSE
CHHHCCCCCCCCCCC
26.6921712546
580PhosphorylationEESGASASTSPSEKT
HHCCCCCCCCCCCCC
27.2421712546
586MethylationASTSPSEKTTPSPTD
CCCCCCCCCCCCCCC
63.13-
586"N6,N6-dimethyllysine"ASTSPSEKTTPSPTD
CCCCCCCCCCCCCCC
63.13-
588PhosphorylationTSPSEKTTPSPTDKA
CCCCCCCCCCCCCCC
32.60-
603AcetylationAGASPAEKGGGPRGD
CCCCCCCCCCCCCCC
66.0319827655
613AcetylationGPRGDAWKYSTDVKL
CCCCCCCCCCCHHHH
30.9219827663
619AcetylationWKYSTDVKLSLNILR
CCCCCHHHHHHHHHH
34.8619827671
710PhosphorylationVPVPERASPGPPTQL
CCCCCCCCCCCCCEE
36.2932142685
715PhosphorylationRASPGPPTQLVLKLK
CCCCCCCCEEEEEEC
37.3523312004
742PhosphorylationARAAAGGTASPGGGA
HHHHHCCCCCCCCCC
24.0423403867
744PhosphorylationAAAGGTASPGGGARR
HHHCCCCCCCCCCCC
24.7423403867
753PhosphorylationGGGARRASASGPVPG
CCCCCCCCCCCCCCC
22.58-
796PhosphorylationGALRPCATYPQQNRS
CHHCCCCCCCCCCCC
42.3128857561
797PhosphorylationALRPCATYPQQNRSL
HHCCCCCCCCCCCCC
4.7828857561
806PhosphorylationQQNRSLSSQSYSPAR
CCCCCCCCCCCCHHH
28.5627732954
808PhosphorylationNRSLSSQSYSPARAA
CCCCCCCCCCHHHHH
29.5327732954
809PhosphorylationRSLSSQSYSPARAAA
CCCCCCCCCHHHHHH
15.8427732954
810PhosphorylationSLSSQSYSPARAAAL
CCCCCCCCHHHHHHH
19.8227732954
822PhosphorylationAALRTVNTVESLARA
HHHHHHHHHHHHHHH
22.7029978859
825PhosphorylationRTVNTVESLARAVPG
HHHHHHHHHHHHCCC
24.0029978859
880MethylationRSNGECGRGGPGPVQ
CCCCCCCCCCCCHHH
59.5658858747

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of OTU7A_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of OTU7A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of OTU7A_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
UBC_HUMANUBCphysical
23827681

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of OTU7A_HUMAN

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Related Literatures of Post-Translational Modification

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