UniProt ID | OTU7A_HUMAN | |
---|---|---|
UniProt AC | Q8TE49 | |
Protein Name | OTU domain-containing protein 7A | |
Gene Name | OTUD7A | |
Organism | Homo sapiens (Human). | |
Sequence Length | 926 | |
Subcellular Localization | Cytoplasm. Nucleus. | |
Protein Description | Has deubiquitinating activity towards 'Lys-11'-linked polyubiquitin chains.. | |
Protein Sequence | MVSSVLPNPTSAECWAALLHDPMTLDMDAVLSDFVRSTGAEPGLARDLLEGKNWDLTAALSDYEQLRQVHTANLPHVFNEGRGPKQPEREPQPGHKVERPCLQRQDDIAQEKRLSRGISHASSAIVSLARSHVASECNNEQFPLEMPIYTFQLPDLSVYSEDFRSFIERDLIEQATMVALEQAGRLNWWSTVCTSCKRLLPLATTGDGNCLLHAASLGMWGFHDRDLVLRKALYTMMRTGAEREALKRRWRWQQTQQNKEEEWEREWTELLKLASSEPRTHFSKNGGTGGGVDNSEDPVYESLEEFHVFVLAHILRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVPPNRCHCSPLVLAYDQAHFSALVSMEQRDQQREQAVIPLTDSEHKLLPLHFAVDPGKDWEWGKDDNDNARLAHLILSLEAKLNLLHSYMNVTWIRIPSETRAPLAQPESPTASAGEDVQSLADSLDSDRDSVCSNSNSNNGKNGKDKEKEKQRKEKDKTRADSVANKLGSFSKTLGIKLKKNMGGLGGLVHGKMGRANSANGKNGDSAERGKEKKAKSRKGSKEESGASASTSPSEKTTPSPTDKAAGASPAEKGGGPRGDAWKYSTDVKLSLNILRAAMQGERKFIFAGLLLTSHRHQFHEEMIGYYLTSAQERFSAEQEQRRRDAATAAAAAAAAAAATAKRPPRRPETEGVPVPERASPGPPTQLVLKLKERPSPGPAAGRAARAAAGGTASPGGGARRASASGPVPGRSPPAPARQSVIHVQASGARDEACAPAVGALRPCATYPQQNRSLSSQSYSPARAAALRTVNTVESLARAVPGALPGAAGTAGAAEHKSQTYTNGFGALRDGLEFADADAPTARSNGECGRGGPGPVQRRCQRENCAFYGRAETEHYCSYCYREELRRRREARGARP | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
24 | Phosphorylation | ALLHDPMTLDMDAVL HHHCCCCCCCHHHHH | 25.62 | 26714015 | |
32 | Phosphorylation | LDMDAVLSDFVRSTG CCHHHHHHHHHHHHC | 23.54 | 26714015 | |
63 | Phosphorylation | LTAALSDYEQLRQVH HHHHCCCHHHHHHHH | 11.38 | 24114839 | |
119 | Phosphorylation | KRLSRGISHASSAIV HHHHHHHCHHHHHHH | 18.80 | 28188228 | |
122 | Phosphorylation | SRGISHASSAIVSLA HHHHCHHHHHHHHHH | 18.19 | 23403867 | |
123 | Phosphorylation | RGISHASSAIVSLAR HHHCHHHHHHHHHHH | 23.85 | 23403867 | |
127 | Phosphorylation | HASSAIVSLARSHVA HHHHHHHHHHHHHHH | 15.36 | 23403867 | |
194 | O-linked_Glycosylation | NWWSTVCTSCKRLLP CHHHHHHHHHHHHHC | 32.59 | 30379171 | |
426 | Phosphorylation | RLAHLILSLEAKLNL HHHHHHHHHHHHHHH | 19.71 | - | |
441 | Phosphorylation | LHSYMNVTWIRIPSE HHHHCCEEEEECCCC | 15.35 | - | |
449 | Phosphorylation | WIRIPSETRAPLAQP EEECCCCCCCCCCCC | 36.15 | 22210691 | |
469 | Phosphorylation | SAGEDVQSLADSLDS CCCHHHHHHHHHCCC | 25.93 | 22210691 | |
476 | Phosphorylation | SLADSLDSDRDSVCS HHHHHCCCCHHHHCC | 39.58 | 22210691 | |
496 | Acetylation | NGKNGKDKEKEKQRK CCCCCCHHHHHHHHH | 74.33 | 7708465 | |
512 | Phosphorylation | KDKTRADSVANKLGS HHHHHHHHHHHHHHH | 23.34 | 28176443 | |
516 | Acetylation | RADSVANKLGSFSKT HHHHHHHHHHHHHHH | 44.48 | 25953088 | |
519 | Phosphorylation | SVANKLGSFSKTLGI HHHHHHHHHHHHHCC | 36.46 | 24719451 | |
522 | Ubiquitination | NKLGSFSKTLGIKLK HHHHHHHHHHCCCCC | 45.84 | 32142685 | |
548 | Phosphorylation | GKMGRANSANGKNGD HCCCCCCCCCCCCCC | 23.33 | 18785766 | |
575 | Phosphorylation | RKGSKEESGASASTS CCCCHHHCCCCCCCC | 40.53 | 21712546 | |
578 | Phosphorylation | SKEESGASASTSPSE CHHHCCCCCCCCCCC | 26.69 | 21712546 | |
580 | Phosphorylation | EESGASASTSPSEKT HHCCCCCCCCCCCCC | 27.24 | 21712546 | |
586 | Methylation | ASTSPSEKTTPSPTD CCCCCCCCCCCCCCC | 63.13 | - | |
586 | "N6,N6-dimethyllysine" | ASTSPSEKTTPSPTD CCCCCCCCCCCCCCC | 63.13 | - | |
588 | Phosphorylation | TSPSEKTTPSPTDKA CCCCCCCCCCCCCCC | 32.60 | - | |
603 | Acetylation | AGASPAEKGGGPRGD CCCCCCCCCCCCCCC | 66.03 | 19827655 | |
613 | Acetylation | GPRGDAWKYSTDVKL CCCCCCCCCCCHHHH | 30.92 | 19827663 | |
619 | Acetylation | WKYSTDVKLSLNILR CCCCCHHHHHHHHHH | 34.86 | 19827671 | |
710 | Phosphorylation | VPVPERASPGPPTQL CCCCCCCCCCCCCEE | 36.29 | 32142685 | |
715 | Phosphorylation | RASPGPPTQLVLKLK CCCCCCCCEEEEEEC | 37.35 | 23312004 | |
742 | Phosphorylation | ARAAAGGTASPGGGA HHHHHCCCCCCCCCC | 24.04 | 23403867 | |
744 | Phosphorylation | AAAGGTASPGGGARR HHHCCCCCCCCCCCC | 24.74 | 23403867 | |
753 | Phosphorylation | GGGARRASASGPVPG CCCCCCCCCCCCCCC | 22.58 | - | |
796 | Phosphorylation | GALRPCATYPQQNRS CHHCCCCCCCCCCCC | 42.31 | 28857561 | |
797 | Phosphorylation | ALRPCATYPQQNRSL HHCCCCCCCCCCCCC | 4.78 | 28857561 | |
806 | Phosphorylation | QQNRSLSSQSYSPAR CCCCCCCCCCCCHHH | 28.56 | 27732954 | |
808 | Phosphorylation | NRSLSSQSYSPARAA CCCCCCCCCCHHHHH | 29.53 | 27732954 | |
809 | Phosphorylation | RSLSSQSYSPARAAA CCCCCCCCCHHHHHH | 15.84 | 27732954 | |
810 | Phosphorylation | SLSSQSYSPARAAAL CCCCCCCCHHHHHHH | 19.82 | 27732954 | |
822 | Phosphorylation | AALRTVNTVESLARA HHHHHHHHHHHHHHH | 22.70 | 29978859 | |
825 | Phosphorylation | RTVNTVESLARAVPG HHHHHHHHHHHHCCC | 24.00 | 29978859 | |
880 | Methylation | RSNGECGRGGPGPVQ CCCCCCCCCCCCHHH | 59.56 | 58858747 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of OTU7A_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of OTU7A_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of OTU7A_HUMAN !! |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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