ZIC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZIC1_HUMAN
• UniProt AC: Q15915
• Protein Name: Zinc finger protein ZIC 1
• Gene Name: ZIC1
• Organism: Homo sapiens (Human).
• Sequence Length: 447
• Subcellular Localization: Nucleus. Cytoplasm. Localizes in the cytoplasm in presence of MDFIC overexpression..
• Protein Description: Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally-located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3' (By similarity)..
• Protein Sequence: MLLDAGPQYPAIGVTTFGASRHHSAGDVAERDVGLGINPFADGMGAFKLNPSSHELASAGQTAFTSQAPGYAAAAALGHHHHPGHVGSYSSAAFNSTRDFLFRNRGFGDAAAAASAQHSLFAASAGGFGGPHGHTDAAGHLLFPGLHEQAAGHASPNVVNGQMRLGFSGDMYPRPEQYGQVTSPRSEHYAAPQLHGYGPMNVNMAAHHGAGAFFRYMRQPIKQELICKWIEPEQLANPKKSCNKTFSTMHELVTHVTVEHVGGPEQSNHICFWEECPREGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFKCEFEGCDRRFANSSDRKKHMHVHTSDKPYLCKMCDKSYTHPSSLRKHMKVHESSSQGSQPSPAASSGYESSTPPTIVSPSTDNPTTSSLSPSSSAVHHTAGHSALSSNFNEWYV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	LLDAGPQYPAIGVTT CCCCCCCCCCEEEEE	9.58	-
15	Phosphorylation	QYPAIGVTTFGASRH CCCCEEEEEECCCCC	15.93	17081983
16	Phosphorylation	YPAIGVTTFGASRHH CCCEEEEEECCCCCC	20.05	17081983
20	Phosphorylation	GVTTFGASRHHSAGD EEEEECCCCCCCCCC	32.31	17081983
172	Phosphorylation	LGFSGDMYPRPEQYG CCCCCCCCCCHHHCC	10.79	27732954
178	Phosphorylation	MYPRPEQYGQVTSPR CCCCHHHCCCCCCCC	14.09	27732954
182	Phosphorylation	PEQYGQVTSPRSEHY HHHCCCCCCCCCCCC	25.73	27732954
183	Phosphorylation	EQYGQVTSPRSEHYA HHCCCCCCCCCCCCC	21.32	27732954
245	Phosphorylation	PKKSCNKTFSTMHEL CCHHCCCCHHHHHHH	14.61	-
247	Phosphorylation	KSCNKTFSTMHELVT HHCCCCHHHHHHHHH	30.01	-
297	Phosphorylation	VNHIRVHTGEKPFPC EEEEEEECCCCCCCC	44.15	-
311	Acetylation	CPFPGCGKVFARSEN CCCCCCCCEEEECCC	37.95	-
325	Phosphorylation	NLKIHKRTHTGEKPF CEEEECCCCCCCCCE	28.70	23312004
327	Phosphorylation	KIHKRTHTGEKPFKC EEECCCCCCCCCEEC	46.56	29496963
375	Phosphorylation	DKSYTHPSSLRKHMK CCCCCCHHHHHHHEE	34.11	27732954
376	Phosphorylation	KSYTHPSSLRKHMKV CCCCCHHHHHHHEEC	36.32	27732954

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZIC1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZIC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZIC1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GLI1_HUMAN	GLI1	physical	11238441
GLI2_HUMAN	GLI2	physical	11238441
GLI3_HUMAN	GLI3	physical	11238441
DR9C7_HUMAN	SDR9C7	physical	28514442
PLBL1_HUMAN	PLBD1	physical	28514442
GDPD3_HUMAN	GDPD3	physical	28514442
CATH_HUMAN	CTSH	physical	28514442
S10A7_HUMAN	S100A7	physical	28514442
SPB4_HUMAN	SERPINB4	physical	28514442
CPNS2_HUMAN	CAPNS2	physical	28514442
CBPA4_HUMAN	CPA4	physical	28514442
PA24E_HUMAN	PLA2G4E	physical	28514442
RNAS7_HUMAN	RNASE7	physical	28514442
AACT_HUMAN	SERPINA3	physical	28514442
SPB3_HUMAN	SERPINB3	physical	28514442
CATL2_HUMAN	CTSV	physical	28514442
ILEU_HUMAN	SERPINB1	physical	28514442
CASPE_HUMAN	CASP14	physical	28514442
LX12B_HUMAN	ALOX12B	physical	28514442
TGM1_HUMAN	TGM1	physical	28514442
S100P_HUMAN	S100P	physical	28514442
KLK7_HUMAN	KLK7	physical	28514442
SAP3_HUMAN	GM2A	physical	28514442
ZA2G_HUMAN	AZGP1	physical	28514442
NGAL_HUMAN	LCN2	physical	28514442
PPAP_HUMAN	ACPP	physical	28514442
ECM1_HUMAN	ECM1	physical	28514442
HUTH_HUMAN	HAL	physical	28514442
INVO_HUMAN	IVL	physical	28514442
GSDMA_HUMAN	GSDMA	physical	28514442
ARGI1_HUMAN	ARG1	physical	28514442
FBX50_HUMAN	NCCRP1	physical	28514442
ASAH1_HUMAN	ASAH1	physical	28514442
IMPA2_HUMAN	IMPA2	physical	28514442
S10AG_HUMAN	S100A16	physical	28514442
APOD_HUMAN	APOD	physical	28514442
KPRP_HUMAN	KPRP	physical	28514442
SPB13_HUMAN	SERPINB13	physical	28514442
S10AE_HUMAN	S100A14	physical	28514442
S10A9_HUMAN	S100A9	physical	28514442
CYTA_HUMAN	CSTA	physical	28514442
CAN1_HUMAN	CAPN1	physical	28514442
LOXE3_HUMAN	ALOXE3	physical	28514442
G3P_HUMAN	GAPDH	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.