GDPD3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GDPD3_HUMAN
• UniProt AC: Q7L5L3
• Protein Name: Lysophospholipase D GDPD3 {ECO:0000305}
• Gene Name: GDPD3 {ECO:0000312|HGNC:HGNC:28638}
• Organism: Homo sapiens (Human).
• Sequence Length: 318
• Subcellular Localization: Membrane ; Multi-pass membrane protein . Cytoplasm, perinuclear region . Endoplasmic reticulum . Partially co-localized with CANX.
• Protein Description: Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) and lysophosphatidylcholine (lyso-PC), and to a lesser extent for lysophosphatidylethanolamine (lyso-PE). Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine..
• Protein Sequence: MSLLLYYALPALGSYAMLSIFFLRRPHLLHTPRAPTFRIRLGAHRGGSGELLENTMEAMENSMAQRSDLLELDCQLTRDRVVVVSHDENLCRQSGLNRDVGSLDFEDLPLYKEKLEVYFSPGHFAHGSDRRMVRLEDLFQRFPRTPMSVEIKGKNEELIREIAGLVRRYDRNEITIWASEKSSVMKKCKAANPEMPLSFTISRGFWVLLSYYLGLLPFIPIPEKFFFCFLPNIINRTYFPFSCSCLNQLLAVVSKWLIMRKSLIRHLEERGVQVVFWCLNEESDFEAAFSVGATGVITDYPTALRHYLDNHGPAARTS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSLLLYYAL ------CCHHHHHHH	27.94	24043423
6	Phosphorylation	--MSLLLYYALPALG --CCHHHHHHHHHHH	6.15	24043423
7	Phosphorylation	-MSLLLYYALPALGS -CCHHHHHHHHHHHH	11.13	24043423
14	Phosphorylation	YALPALGSYAMLSIF HHHHHHHHHHHHHHH	15.57	24043423
15	Phosphorylation	ALPALGSYAMLSIFF HHHHHHHHHHHHHHH	8.33	24043423
19	Phosphorylation	LGSYAMLSIFFLRRP HHHHHHHHHHHHHCC	12.31	24043423
31	Phosphorylation	RRPHLLHTPRAPTFR HCCCHHCCCCCCEEE	17.91	24043423
102	Phosphorylation	GLNRDVGSLDFEDLP CCCCCCCCCCCCCCC	25.31	21406692
111	Phosphorylation	DFEDLPLYKEKLEVY CCCCCCCHHHEEEEE	18.37	21406692
128	Phosphorylation	PGHFAHGSDRRMVRL CCCCCCCCCCCEEEH	20.34	-
145	Phosphorylation	LFQRFPRTPMSVEIK HHHHCCCCCCEEEEC	24.47	20071362
154	Ubiquitination	MSVEIKGKNEELIRE CEEEECCCCHHHHHH	57.07	33845483
169	Phosphorylation	IAGLVRRYDRNEITI HHHHHHHHCCCCEEE	14.53	19702290
175	Phosphorylation	RYDRNEITIWASEKS HHCCCCEEEEECCCC	12.32	19702290
179	Phosphorylation	NEITIWASEKSSVMK CCEEEEECCCCHHHH	30.47	19702290
200	Phosphorylation	PEMPLSFTISRGFWV CCCCEEEEEHHHHHH	18.05	22210691
262	Phosphorylation	KWLIMRKSLIRHLEE HHHHHHHHHHHHHHH	20.75	24719451
300	Phosphorylation	ATGVITDYPTALRHY CCEEECCHHHHHHHH	8.20	22210691
302	Phosphorylation	GVITDYPTALRHYLD EEECCHHHHHHHHHH	31.90	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GDPD3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GDPD3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GDPD3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of GDPD3_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.