RN180_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RN180_HUMAN
• UniProt AC: Q86T96
• Protein Name: E3 ubiquitin-protein ligase RNF180
• Gene Name: RNF180
• Organism: Homo sapiens (Human).
• Sequence Length: 592
• Subcellular Localization: Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus envelope .
• Protein Description: E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2..
• Protein Sequence: MKRSKELITKNHSQEETSILRCWKCRKCIASSGCFMEYLENQVIKDKDDSVDAQNICHVWHMNVEALPEWISCLIQKAQWTVGKLNCPFCGARLGGFNFVSTPKCSCGQLAAVHLSKSRTDYQPTQAGRLMRPSVKYLSHPRVQSGCDKEALLTGGGSENRNHRLLNMARNNNDPGRLTEALCLEVRPTYFEMKNEKLLSKASEPKYQLFVPQLVTGRCATRAFHRKSHSLDLNISEKLTLLPTLYEIHSKTTAYSRLNETQPIDLSGLPLQSSKNSYSFQNPSSFDPSMLLQRFSVAPHETQTQRGGEFQCGLEAASVYSDHTNTNNLTFLMDLPSAGRSMPEASDQEEHLSPLDFLHSANFSLGSINQRLNKRERSKLKNLRRKQRRRERWLQKQGKYSGVGLLDHMTLNNEMSTDEDNEYAEEKDSYICAVCLDVYFNPYMCYPCHHIFCEPCLRTLAKDNPSSTPCPLCRTIISRVFFQTELNNATKTFFTKEYLKIKQSFQKSNSAKWPLPSCRKAFHLFGGFRRHAAPVTRRQFPHGAHRMDYLHFEDDSRGWWFDMDMVIIYIYSVNWVIGFIVFCFLCYFFFPF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MKRSKELITKN ----CCCHHHHHHCC	25.59	24670416
13	Phosphorylation	ELITKNHSQEETSIL HHHHCCCCCHHHHHH	48.99	29255136
17	Phosphorylation	KNHSQEETSILRCWK CCCCCHHHHHHHHHC	21.95	29255136
18	Phosphorylation	NHSQEETSILRCWKC CCCCHHHHHHHHHCC	23.94	24719451
125	Phosphorylation	SRTDYQPTQAGRLMR CCCCCCCCHHHHCCC	18.61	23532336
137	Phosphorylation	LMRPSVKYLSHPRVQ CCCCCCHHHCCCCCC	15.98	-
207	Phosphorylation	SKASEPKYQLFVPQL HCCCCCCEEEECCHH	22.59	23532336
216	Phosphorylation	LFVPQLVTGRCATRA EECCHHHHCCHHHHH	27.74	23532336
228	Phosphorylation	TRAFHRKSHSLDLNI HHHHHHHCCCCCCCH	20.47	30266825
230	Phosphorylation	AFHRKSHSLDLNISE HHHHHCCCCCCCHHH	30.57	30266825
236	Phosphorylation	HSLDLNISEKLTLLP CCCCCCHHHHHHHHH	27.83	-
244	Phosphorylation	EKLTLLPTLYEIHSK HHHHHHHHHHHHHCC	41.77	29116813
246	Phosphorylation	LTLLPTLYEIHSKTT HHHHHHHHHHHCCCC	18.47	29116813
253	Phosphorylation	YEIHSKTTAYSRLNE HHHHCCCCHHHCCCC	27.60	29116813
255	Phosphorylation	IHSKTTAYSRLNETQ HHCCCCHHHCCCCCC	7.70	29116813
256	Phosphorylation	HSKTTAYSRLNETQP HCCCCHHHCCCCCCC	28.03	29116813
261	Phosphorylation	AYSRLNETQPIDLSG HHHCCCCCCCCCCCC	38.27	28111955
267	Phosphorylation	ETQPIDLSGLPLQSS CCCCCCCCCCCCCCC	34.24	28111955
273	Phosphorylation	LSGLPLQSSKNSYSF CCCCCCCCCCCCCCC	51.46	28111955
274	Phosphorylation	SGLPLQSSKNSYSFQ CCCCCCCCCCCCCCC	23.93	28111955
302	Phosphorylation	FSVAPHETQTQRGGE EEECCCCCCCCCCCE	33.60	22210691
304	Phosphorylation	VAPHETQTQRGGEFQ ECCCCCCCCCCCEEC	27.88	22210691
341	Phosphorylation	DLPSAGRSMPEASDQ ECCCCCCCCCCCCCC	37.46	22210691
364	Phosphorylation	FLHSANFSLGSINQR HHHHCCCCHHHHHHH	31.46	22210691
367	Phosphorylation	SANFSLGSINQRLNK HCCCCHHHHHHHCCH	24.53	22210691
410	Phosphorylation	VGLLDHMTLNNEMST CCHHCCEECCCCCCC	23.94	29759185
417	Phosphorylation	TLNNEMSTDEDNEYA ECCCCCCCCCCCHHH	41.94	29759185
423	Phosphorylation	STDEDNEYAEEKDSY CCCCCCHHHHHHHHE	26.10	29759185
475	Phosphorylation	TPCPLCRTIISRVFF CCCHHHHHHHHHHHH	22.97	29759185
478	Phosphorylation	PLCRTIISRVFFQTE HHHHHHHHHHHHHHH	20.67	29759185

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RN180_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RN180_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RN180_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZIC2_HUMAN	ZIC2	physical	18363970

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.