dbPTM

BCL3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	BCL3_HUMAN
UniProt AC	P20749
Protein Name	B-cell lymphoma 3 protein
Gene Name	BCL3
Organism	Homo sapiens (Human).
Sequence Length	454
Subcellular Localization	Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation..
Protein Description	Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity)..
Protein Sequence	MPRCPAGAMDEGPVDLRTRPKAAGLPGAALPLRKRPLRAPSPEPAAPRGAAGLVVPLDPLRGGCDLPAVPGPPHGLARPEALYYPGALLPLYPTRAMGSPFPLVNLPTPLYPMMCPMEHPLSADIAMATRADEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDILRGKATRPASTSQPDPSPDRSANTSPESSSRLSSNGLLSASPSSSPSQSPPRDPPGFPMAPPNFFLPSPSPPAFLPFAGVLRGPGRPVPPSPAPGGS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Ubiquitination	VDLRTRPKAAGLPGA CCCCCCCCCCCCCCC	47.80	15469820
34	Ubiquitination	GAALPLRKRPLRAPS CCCCCCCCCCCCCCC	67.08	1546982
41	Phosphorylation	KRPLRAPSPEPAAPR CCCCCCCCCCCCCCC	40.69	29255136
83	Phosphorylation	LARPEALYYPGALLP CCCHHHHCCCCCCCC	18.05	27642862
84	Phosphorylation	ARPEALYYPGALLPL CCHHHHCCCCCCCCC	8.95	-
122	Phosphorylation	CPMEHPLSADIAMAT CCCCCCCCCCEEEHH	28.48	-
174	Phosphorylation	IYNNLRQTPLHLAVI CCCCCCCCCCHHHHH	22.76	24043423
182	Phosphorylation	PLHLAVITTLPSVVR CCHHHHHHCHHHHHH	18.71	24043423
183	Phosphorylation	LHLAVITTLPSVVRL CHHHHHHCHHHHHHH	26.08	24043423
186	Phosphorylation	AVITTLPSVVRLLVT HHHHCHHHHHHHHHH	36.04	24043423
193	Phosphorylation	SVVRLLVTAGASPMA HHHHHHHHCCCCCCE	21.24	24043423
197	Phosphorylation	LLVTAGASPMALDRH HHHHCCCCCCEECCC	17.81	24043423
338	Methylation	SGADSSLKNCHNDTP CCCCHHHHCCCCCCC	60.52	-
363	Phosphorylation	DILRGKATRPASTSQ HHHCCCCCCCCCCCC	40.44	23403867
367	Phosphorylation	GKATRPASTSQPDPS CCCCCCCCCCCCCCC	31.13	23403867
368	Phosphorylation	KATRPASTSQPDPSP CCCCCCCCCCCCCCC	33.22	23403867
369	Phosphorylation	ATRPASTSQPDPSPD CCCCCCCCCCCCCCC	36.90	23663014
374	Phosphorylation	STSQPDPSPDRSANT CCCCCCCCCCCCCCC	46.98	23401153
378	Phosphorylation	PDPSPDRSANTSPES CCCCCCCCCCCCHHH	33.00	28985074
381	Phosphorylation	SPDRSANTSPESSSR CCCCCCCCCHHHHHH	45.43	28985074
382	Phosphorylation	PDRSANTSPESSSRL CCCCCCCCHHHHHHH	26.86	25849741
385	Phosphorylation	SANTSPESSSRLSSN CCCCCHHHHHHHHCC	36.68	23927012
386	Phosphorylation	ANTSPESSSRLSSNG CCCCHHHHHHHHCCC	20.16	23927012
387	Phosphorylation	NTSPESSSRLSSNGL CCCHHHHHHHHCCCC	46.66	23927012
402	Phosphorylation	LSASPSSSPSQSPPR CCCCCCCCCCCCCCC	32.67	15469820
406	Phosphorylation	PSSSPSQSPPRDPPG CCCCCCCCCCCCCCC	41.01	15469820
448	Phosphorylation	PGRPVPPSPAPGGS- CCCCCCCCCCCCCC-	27.85	29396449
454	Phosphorylation	PSPAPGGS------- CCCCCCCC-------	42.85	21712546

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
41	S	Phosphorylation	Kinase	AKT1	P31749	PSP
41	S	Phosphorylation	Kinase	AKT1	P31750	PSP
122	S	Phosphorylation	Kinase	MAPK1	P63086	GPS
402	S	Phosphorylation	Kinase	GSK3A	P49840	PSP
402	S	Phosphorylation	Kinase	GSK-FAMILY	-	GPS
402	S	Phosphorylation	Kinase	GSK3	-	Uniprot
406	S	Phosphorylation	Kinase	GSK3A	P49840	PSP
406	S	Phosphorylation	Kinase	GSK-FAMILY	-	GPS
406	S	Phosphorylation	Kinase	GSK3	-	Uniprot
454	S	Phosphorylation	Kinase	CHUK	O15111	GPS
454	S	Phosphorylation	Kinase	IKBKB	O14920	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of BCL3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of BCL3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BARD1_HUMAN	BARD1	physical	10362352
NFKB1_HUMAN	NFKB1	physical	14678988
NFKB1_HUMAN	NFKB1	physical	8428580
RELB_HUMAN	RELB	physical	14678988
N4BP2_HUMAN	N4BP2	physical	12730195
PIR_HUMAN	PIR	physical	10362352
KAT5_HUMAN	KAT5	physical	10362352
CSN5_HUMAN	COPS5	physical	10362352
JUN_HUMAN	JUN	physical	10497212
FOS_HUMAN	FOS	physical	10497212
EP300_HUMAN	EP300	physical	10497212
NCOA1_HUMAN	NCOA1	physical	10497212
NFKB1_HUMAN	NFKB1	physical	10469655
TBP_HUMAN	TBP	physical	9812988
RXRA_HUMAN	RXRA	physical	9812988
TF2AA_HUMAN	GTF2A1	physical	9812988
TF2B_HUMAN	GTF2B	physical	9812988
CYLD_HUMAN	CYLD	physical	19893491
STAT1_HUMAN	STAT1	physical	16306601
STAT3_HUMAN	STAT3	physical	16306601
HDAC1_HUMAN	HDAC1	physical	16306601
HSP74_HUMAN	HSPA4	physical	20547759
TBL1R_HUMAN	TBL1XR1	physical	20547759
CTBP1_HUMAN	CTBP1	physical	20547759
CTBP2_HUMAN	CTBP2	physical	20547759
BAG2_HUMAN	BAG2	physical	20547759
HDAC3_HUMAN	HDAC3	physical	20547759
RCOR1_HUMAN	RCOR1	physical	20547759
KDM1A_HUMAN	KDM1A	physical	20547759
NFKB1_HUMAN	NFKB1	physical	20547759
GSK3B_HUMAN	GSK3B	physical	15469820
HDAC1_HUMAN	HDAC1	physical	15469820
NFKB1_HUMAN	NFKB1	physical	20558726
NFKB2_HUMAN	NFKB2	physical	20558726
PSB1_HUMAN	PSMB1	physical	20558726
FBXW8_HUMAN	FBXW8	physical	20558726
CTNB1_HUMAN	CTNNB1	physical	15829968
CTBP1_HUMAN	CTBP1	physical	20800578
NFKB1_HUMAN	NFKB1	physical	20800578
NFKB2_HUMAN	NFKB2	physical	20800578
RUVB1_HUMAN	RUVBL1	physical	20800578
RUVB2_HUMAN	RUVBL2	physical	20800578
BCL10_HUMAN	BCL10	physical	16280327
CTBP2_HUMAN	CTBP2	physical	21988832
NFKB2_HUMAN	NFKB2	physical	28689659

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of BCL3_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"GSK3-mediated BCL-3 phosphorylation modulates its degradation and itsoncogenicity."; Viatour P., Dejardin E., Warnier M., Lair F., Claudio E., Bureau F.,Marine J.C., Merville M.P., Maurer U., Green D., Piette J.,Siebenlist U., Bours V., Chariot A.; Mol. Cell 16:35-45(2004). Cited for: PHOSPHORYLATION AT SER-404 AND SER-406.	15469820 [Abstract]