dbPTM

TOR2X_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TOR2X_HUMAN
UniProt AC	Q8N2E6
Protein Name	Prosalusin
Gene Name	TOR2A
Organism	Homo sapiens (Human).
Sequence Length	242
Subcellular Localization	Secreted .
Protein Description	Salusins -alpha and -beta may be endocrine and/or paracrine factors able to increase intracellular calcium concentrations and induce cell mitogenesis. Salusins may also be potent hypotensive peptides..
Protein Sequence	MAAATRGCRPWGSLLGLLGLVSAAAAAWDLASLRCTLGAFCECDFRPDLPGLECDLAQHLAGQHLAKALVVKALKAFVRDPAPTKPLVLSLHGWTGTGKSYVSSLLAHYLFQGGLRSPRVHHFSPVLHFPHPSHIERYKKDLKSWVQGNLTACGRSLFLFDEMDKMPPGLMEVLRPFLGSSWVVYGTNYRKAIFIFIRWLLKLGHHGRAPPRRSGALPPAPAAPRPALRAQRAGPAGPGAKG

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
149	N-linked_Glycosylation	LKSWVQGNLTACGRS HHHHHHCCCCHHCCE	19.68	UniProtKB CARBOHYD
241	Lysine amide	GPAGPGAKG------ CCCCCCCCC------	71.69	-
241	Amidation	GPAGPGAKG------ CCCCCCCCC------	71.69	12910263

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TOR2X_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TOR2X_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TOR2X_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of TOR2X_HUMAN !!

Drug and Disease Associations

Kegg Disease
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TOR2X_HUMAN

Related Literatures of Post-Translational Modification

Amidation
Reference	PubMed
"Salusins: newly identified bioactive peptides with hemodynamic andmitogenic activities."; Shichiri M., Ishimaru S., Ota T., Nishikawa T., Isogai T., Hirata Y.; Nat. Med. 9:1166-1172(2003). Cited for: FUNCTION OF SALUSINS, TISSUE SPECIFICITY, AMIDATION AT LYS-241, ANDSUBCELLULAR LOCATION.	12910263 [Abstract]