HEMGN_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HEMGN_HUMAN
• UniProt AC: Q9BXL5
• Protein Name: Hemogen
• Gene Name: HEMGN
• Organism: Homo sapiens (Human).
• Sequence Length: 484
• Subcellular Localization: Nucleus .
• Protein Description: Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB)..
• Protein Sequence: MDLGKDQSHLKHHQTPDPHQEENHSPEVIGTWSLRNRELLRKRKAEVHEKETSQWLFGEQKKRKQQRTGKGNRRGRKRQQNTELKVEPQPQIEKEIVEKALAPIEKKTEPPGSITKVFPSVASPQKVVPEEHFSEICQESNIYQENFSEYQEIAVQNHSSETCQHVSEPEDLSPKMYQEISVLQDNSSKICQDMKEPEDNSPNTCQVISVIQDHPFKMYQDMAKREDLAPKMCQEAAVPKILPCPTSEDTADLAGCSLQAYPKPDVPKGYILDTDQNPAEPEEYNETDQGIAETEGLFPKIQEIAEPKDLSTKTHQESAEPKYLPHKTCNEIIVPKAPSHKTIQETPHSEDYSIEINQETPGSEKYSPETYQEIPGLEEYSPEIYQETSQLEEYSPEIYQETPGPEDLSTETYKNKDVPKECFPEPHQETGGPQGQDPKAHQEDAKDAYTFPQEMKEKPKEEPGIPAILNESHPENDVYSYVLF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Acetylation	---MDLGKDQSHLKH ---CCCCCCHHHHCC	60.95	23749302
15	Phosphorylation	SHLKHHQTPDPHQEE HHHCCCCCCCCCCCC	25.88	23898821
25	Phosphorylation	PHQEENHSPEVIGTW CCCCCCCCCCCEEHH	34.05	23898821
31	Phosphorylation	HSPEVIGTWSLRNRE CCCCCEEHHHHHCHH	10.76	23898821
33	Phosphorylation	PEVIGTWSLRNRELL CCCEEHHHHHCHHHH	19.79	24719451
94	Acetylation	EPQPQIEKEIVEKAL CCCCHHHHHHHHHHH	55.13	30585865
99	Acetylation	IEKEIVEKALAPIEK HHHHHHHHHHHCHHC	37.49	30585857
108	Phosphorylation	LAPIEKKTEPPGSIT HHCHHCCCCCCCCCC	65.87	29083192
113	Phosphorylation	KKTEPPGSITKVFPS CCCCCCCCCCEEECC	32.62	25262027
115	Phosphorylation	TEPPGSITKVFPSVA CCCCCCCCEEECCCC	23.89	25262027
120	Phosphorylation	SITKVFPSVASPQKV CCCEEECCCCCCCCC	20.89	26552605
123	Phosphorylation	KVFPSVASPQKVVPE EEECCCCCCCCCCCH	26.21	23401153
159	Phosphorylation	EIAVQNHSSETCQHV HHHCCCCCCCCCCCC	37.10	-
167	Phosphorylation	SETCQHVSEPEDLSP CCCCCCCCCHHHCCH	45.36	-
173	Phosphorylation	VSEPEDLSPKMYQEI CCCHHHCCHHHHHHH	34.49	26074081
177	Phosphorylation	EDLSPKMYQEISVLQ HHCCHHHHHHHHHHC	14.77	28796482
181	Phosphorylation	PKMYQEISVLQDNSS HHHHHHHHHHCCCCC	18.93	23917254
187	Phosphorylation	ISVLQDNSSKICQDM HHHHCCCCCHHCCCC	41.10	23186163
188	Phosphorylation	SVLQDNSSKICQDMK HHHCCCCCHHCCCCC	32.09	23186163
201	Phosphorylation	MKEPEDNSPNTCQVI CCCCCCCCCCCCEEE	31.67	23401153
204	Phosphorylation	PEDNSPNTCQVISVI CCCCCCCCCEEEEEE	14.01	28464451
209	Phosphorylation	PNTCQVISVIQDHPF CCCCEEEEEECCCCC	17.82	26434776
246	Phosphorylation	PKILPCPTSEDTADL CCCCCCCCCCCCCCC	52.01	23186163
247	Phosphorylation	KILPCPTSEDTADLA CCCCCCCCCCCCCCC	20.72	23186163
250	Phosphorylation	PCPTSEDTADLAGCS CCCCCCCCCCCCCCC	20.30	28165663
257	Phosphorylation	TADLAGCSLQAYPKP CCCCCCCCCEEECCC	23.69	28165663
261	Phosphorylation	AGCSLQAYPKPDVPK CCCCCEEECCCCCCC	9.99	23186163
308	Acetylation	IQEIAEPKDLSTKTH HHHHCCCCCCCHHCH	63.91	30585869
314	Phosphorylation	PKDLSTKTHQESAEP CCCCCHHCHHHHCCC	28.96	22210691
322	Acetylation	HQESAEPKYLPHKTC HHHHCCCCCCCCCCC	51.42	30585861
323	Phosphorylation	QESAEPKYLPHKTCN HHHCCCCCCCCCCCC	35.86	-
327	Acetylation	EPKYLPHKTCNEIIV CCCCCCCCCCCEEEC	53.48	7960585
339	Phosphorylation	IIVPKAPSHKTIQET EECCCCCCCCCCCCC	42.34	-
342	Phosphorylation	PKAPSHKTIQETPHS CCCCCCCCCCCCCCC	23.59	30576142
346	Phosphorylation	SHKTIQETPHSEDYS CCCCCCCCCCCCCCE	15.21	30576142
349	Phosphorylation	TIQETPHSEDYSIEI CCCCCCCCCCCEEEE	33.11	30576142
352	Phosphorylation	ETPHSEDYSIEINQE CCCCCCCCEEEEECC	13.90	23186163
353	Phosphorylation	TPHSEDYSIEINQET CCCCCCCEEEEECCC	26.52	30576142
360	Phosphorylation	SIEINQETPGSEKYS EEEEECCCCCCCCCC	24.16	23917254
363	Phosphorylation	INQETPGSEKYSPET EECCCCCCCCCCHHH	31.92	30576142
367	Phosphorylation	TPGSEKYSPETYQEI CCCCCCCCHHHHHCC	27.59	-
380	Phosphorylation	EIPGLEEYSPEIYQE CCCCHHHCCHHHHHH	21.83	26074081
381	Phosphorylation	IPGLEEYSPEIYQET CCCHHHCCHHHHHHH	21.24	26074081
395	Phosphorylation	TSQLEEYSPEIYQET HHHHHHHCHHHHHHC	21.24	-
399	Phosphorylation	EEYSPEIYQETPGPE HHHCHHHHHHCCCCC	9.91	-
449	Phosphorylation	QEDAKDAYTFPQEMK HHHHHHHCCCCHHHH	21.03	28796482
450	Phosphorylation	EDAKDAYTFPQEMKE HHHHHHCCCCHHHHH	30.47	28176486
479	Phosphorylation	SHPENDVYSYVLF-- CCCCCCCEEEEEC--	9.35	21447384

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HEMGN_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HEMGN_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HEMGN_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EP300_HUMAN	EP300	physical	24740910
GATA1_HUMAN	GATA1	physical	24740910
CSN4_HUMAN	COPS4	physical	24740910
CTBP1_HUMAN	CTBP1	physical	24740910
ENOA_HUMAN	ENO1	physical	24740910
FBRL_HUMAN	FBL	physical	24740910
H2A1C_HUMAN	HIST1H2AC	physical	24740910
HM20A_HUMAN	HMG20A	physical	24740910
HMGA1_HUMAN	HMGA1	physical	24740910
HSP7C_HUMAN	HSPA8	physical	24740910
MED17_HUMAN	MED17	physical	24740910
KAT6A_HUMAN	KAT6A	physical	24740910
NPM_HUMAN	NPM1	physical	24740910
SP100_HUMAN	SP100	physical	24740910
THA11_HUMAN	THAP11	physical	24740910
ZBTB1_HUMAN	ZBTB1	physical	24740910

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.