UNC80_HUMAN - dbPTM
UNC80_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID UNC80_HUMAN
UniProt AC Q8N2C7
Protein Name Protein unc-80 homolog
Gene Name UNC80
Organism Homo sapiens (Human).
Sequence Length 3258
Subcellular Localization Membrane
Multi-pass membrane protein .
Protein Description Component of the NALCN sodium channel complex, required for channel regulation. This complex is a cation channel activated by neuropeptides substance P, neurotensin, and extracellular calcium that regulates neuronal excitability by controlling the sizes of NALCN-dependent sodium-leak current. UNC80 is essential for NALCN sensitivity to extracellular calcium..
Protein Sequence MVKRKSSEGQEQDGGRGIPLPIQTFLWRQTSAFLRPKLGKQYEASCVSFERVLVENKLHGLSPALSEAIQSISRWELVQAALPHVLHCTATLLSNRNKLGHQDKLGVAETKLLHTLHWMLLEAPQDCNNERFGGTDRGSSWGGSSSAFIHQVENQGSPGQPCQSSSNDEEENNRRKIFQNSMATVELFVFLFAPLVHRIKESDLTFRLASGLVIWQPMWEHRQPGVSGFTALVKPIRNIITAKRSSPINSQSRTCESPNQDARHLEGLQVVCETFQSDSISPKATISGCHRGNSFDGSLSSQTSQERGPSHSRASLVIPPCQRSRYATYFDVAVLRCLLQPHWSEEGTQWSLMYYLQRLRHMLEEKPEKPPEPDIPLLPRPRSSSMVAAAPSLVNTHKTQDLTMKCNEEEKSLSSEAFSKVSLTNLRRSAVPDLSSDLGMNIFKKFKSRKEDRERKGSIPFHHTGKRRPRRMGVPFLLHEDHLDVSPTRSTFSFGSFSGLGEDRRGIEKGGWQTTILGKLTRRGSSDAATEMESLSARHSHSHHTLVSDLPDPSNSHGENTVKEVRSQISTITVATFNTTLASFNVGYADFFNEHMRKLCNQVPIPEMPHEPLACANLPRSLTDSCINYSYLEDTEHIDGTNNFVHKNGMLDLSVVLKAVYLVLNHDISSRICDVALNIVECLLQLGVVPCVEKNRKKSENKENETLEKRPSEGAFQFKGVSGSSTCGFGGPAVSGAGDGGGEEGGGGDGGGGGGDGGGGGGGGGGPYEKNDKNQEKDESTPVSNHRLALTMLIKIVKSLGCAYGCGEGHRGLSGDRLRHQVFRENAQNCLTKLYKLDKMQFRQTMRDYVNKDSLNNVVDFLHALLGFCMEPVTDNKAGFGNNFTTVDNKSTAQNVEGIIVSAMFKSLITRCASTTHELHSPENLGLYCDIRQLVQFIKEAHGNVFRRVALSALLDSAEKLAPGKKVEENEQESKPAGSKRSEAGSIVDKGQVSSAPEECRSFMSGRPSQTPEHDEQMQGANLGRKDFWRKMFKSQSAASDTSSQSEQDTSECTTAHSGTTSDRRARSRSRRISLRKKLKLPIGKRNWLKRSSLSGLADGVEDLLDISSVDRLSFIRQSSKVKFTSAVKLSEGGPGSGMENGRDEEENFFKRLGCHSFDDHLSPNQDGGKSKNVVNLGAIRQGMKRFQFLLNCCEPGTIPDASILAAALDLEAPVVARAALFLECARFVHRCNRGNWPEWMKGHHVNITKKGLSRGRSPIVGNKRNQKLQWNAAKLFYQWGDAIGVRLNELCHGESESPANLLGLIYDEETKRRLRKEDEEEDFLDDSTVNPSKCGCPFALKMAACQLLLEITTFLRETFSCLPRPRTEPLVDLESCRLRLDPELDRHRYERKISFAGVLDENEDSKDSLHSSSHTLKSDAGVEEKKEGSPWSASEPSIEPEGMSNAGAEENYHRNMSWLHVMILLCNQQSFICTHVDYCHPHCYLHHSRSCARLVRAIKLLYGDSVDSLRESSNISSVALRGKKQKECSDKSCLRTPSLKKRVSDANLEGKKDSGMLKYIRLQVMSLSPAPLSLLIKAAPILTEEMYGDIQPAAWELLLSMDEHMAGAAAAMFLLCAVKVPEAVSDMLMSEFHHPETVQRLNAVLKFHTLWRFRYQVWPRMEEGAQQIFKIPPPSINFTLPSPVLGMPSVPMFDPPWVPQCSGSVQDPINEDQSKSFSARAVSRSHQRAEHILKNLQQEEEKKRLGREASLITAIPITQEACYEPTCTPNSEPEEEVEEVTNLASRRLSVSPSCTSSTSHRNYSFRRGSVWSVRSAVSAEDEEHTTEHTPNHHVPQPPQAVFPACICAAVLPIVHLMEDGEVREDGVAVSAVAQQVLWNCLIEDPSTVLRHFLEKLTISNRQDELMYMLRKLLLNIGDFPAQTSHILFNYLVGLIMYFVRTPCEWGMDAISATLTFLWEVVGYVEGLFFKDLKQTMKKEQCEVKLLVTASMPGTKTLVVHGQNECDIPTQLPVHEDTQFEALLKECLEFFNIPESQSTHYFLMDKRWNLIHYNKTYVRDIYPFRRSVSPQLNLVHMHPEKGQELIQKQVFTRKLEEVGRVLFLISLTQKIPTAHKQSHVSMLQEDLLRLPSFPRSAIDAEFSLFSDPQAGKELFGLDTLQKSLWIQLLEEMFLGMPSEFPWGDEIMLFLNVFNGALILHPEDSALLRQYAATVINTAVHFNHLFSLSGYQWILPTMLQVYSDYESNPQLRQAIEFACHQFYILHRKPFVLQLFASVAPLLEFPDAANNGPSKGVSAQCLFDLLQSLEGETTDILDILELVKAEKPLKSLDFCYGNEDLTFSISEAIKLCVTVVAYAPESFRSLQMLMVLEALVPCYLQKLKRQTSQVETVPAAREEIAATAALATSLQALLYSVEVLTRPMTAPQMSRCDQGHKGTTTANHTMSSGVNTRYQEQGAKLHFIRENLHLLEEGQGIPREELDERIAREEFRRPRESLLNICTEFYKHCGPRLKILQNLAGEPRVIALELLDVKSHMRLAEIAHSLLKLAPYDTQTMESRGLRRYIMEMLPITDWTAEAVRPALILILKRLDRMFNKIHKMPTLRRQVEWEPASNLIEGVCLTLQRQPIISFLPHLRSLINVCVNLVMGVVGPSSVADGLPLLHLSPYLSPPLPFSTAVVRLVALQIQALKEDFPLSHVISPFTNQERREGMLLNLLIPFVLTVGSGSKDSPWLEQPEVQLLLQTVINVLLPPRIISTSRSKNFMLESSPAHCSTPGDAGKDLRREGLAESTSQAAYLALKVILVCFERQLGSQWYWLSLQVKEMALRKVGGLALWDFLDFIVRTRIPIFVLLRPFIQCKLLAQPAENHEELSARQHIADQLERRFIPRPLCKSSLIAEFNSELKILKEAVHSGSAYQGKTSISTVGTSTSAYRLSLATMSRSNTGTGTVWEQDSEPSQQASQDTLSRTDEEDEENDSISMPSVVSEQEAYLLSAIGRRRFSSHVSSMSVPQAEVGMLPSQSEPNVLDDSQGLAAEGSLSRVASIQSEPGQQNLLVQQPLGRKRGLRQLRRPLLSRQKTQTEPRNRQGARLSTTRRSIQPKTKPSADQKRSVTFIEAQPEPAAAPTDALPATGQLQGCSPAPSRKPEAMDEPVLTSSPAIVVADLHSVSPKQSENFPTEEGEKEEDTEAQGATAHSPLSAQLSDPDDFTGLETSSLLQHGDTVLHISEENGMENPLLSSQFTFTPTELGKTDAVLDESHV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
245PhosphorylationNIITAKRSSPINSQS
HHHHHCCCCCCCCCC		39.5025278378
246PhosphorylationIITAKRSSPINSQSR
HHHHCCCCCCCCCCC		33.5625278378
250PhosphorylationKRSSPINSQSRTCES
CCCCCCCCCCCCCCC		30.1925278378
252PhosphorylationSSPINSQSRTCESPN
CCCCCCCCCCCCCCC		29.4030576142
257PhosphorylationSQSRTCESPNQDARH
CCCCCCCCCCCCHHH		31.15-
294PhosphorylationSGCHRGNSFDGSLSS
EECCCCCCCCCCCCC		27.78-
392PhosphorylationSMVAAAPSLVNTHKT
CCCCCCCCHHHCCCC		39.98-
399PhosphorylationSLVNTHKTQDLTMKC
CHHHCCCCCCCCCCC		21.5128509920
403PhosphorylationTHKTQDLTMKCNEEE
CCCCCCCCCCCCHHH		23.9128509920
446 (in isoform 6)Phosphorylation-10.0228111955
446 (in isoform 5)Phosphorylation-10.0228111955
447 (in isoform 6)Phosphorylation-59.2228111955
447 (in isoform 5)Phosphorylation-59.2228111955
450 (in isoform 5)Phosphorylation-71.6828111955
450 (in isoform 6)Phosphorylation-71.6828111955
451 (in isoform 5)Phosphorylation-62.2828111955
451 (in isoform 6)Phosphorylation-62.2828111955
525PhosphorylationGKLTRRGSSDAATEM
HHHHCCCCCCHHHHH		24.1923322592
526PhosphorylationKLTRRGSSDAATEME
HHHCCCCCCHHHHHH		33.8123322592
540PhosphorylationESLSARHSHSHHTLV
HHHHHHHCCCCCCCC		22.5722468782
545PhosphorylationRHSHSHHTLVSDLPD
HHCCCCCCCCCCCCC		24.3522468782
548PhosphorylationHSHHTLVSDLPDPSN
CCCCCCCCCCCCCCC		36.2222468782
654PhosphorylationKNGMLDLSVVLKAVY
CCCCCHHHHHHHHHH		15.17-
780PhosphorylationKNQEKDESTPVSNHR
CCCCCCCCCCCCHHH		48.4122167270
781PhosphorylationNQEKDESTPVSNHRL
CCCCCCCCCCCHHHH		26.1822167270
784PhosphorylationKDESTPVSNHRLALT
CCCCCCCCHHHHHHH		28.2822167270
791PhosphorylationSNHRLALTMLIKIVK
CHHHHHHHHHHHHHH		12.3430301811
799PhosphorylationMLIKIVKSLGCAYGC
HHHHHHHHHCCCCCC		21.06-
907PhosphorylationIVSAMFKSLITRCAS
HHHHHHHHHHHHHHH		17.4624719451
982PhosphorylationKPAGSKRSEAGSIVD
CCCCCCCCCCCCCCC		35.2222496350
986PhosphorylationSKRSEAGSIVDKGQV
CCCCCCCCCCCCCCC		26.8723322592
994PhosphorylationIVDKGQVSSAPEECR
CCCCCCCCCCCHHHH		16.9423322592
1054PhosphorylationEQDTSECTTAHSGTT
CCCCCCCCCCCCCCC		23.9822468782
1058PhosphorylationSECTTAHSGTTSDRR
CCCCCCCCCCCCHHH		35.06-
1060PhosphorylationCTTAHSGTTSDRRAR
CCCCCCCCCCHHHHH		26.5822468782
1092PhosphorylationKRNWLKRSSLSGLAD
CCCHHHHHHCCCCCC		33.7629691806
1093PhosphorylationRNWLKRSSLSGLADG
CCHHHHHHCCCCCCC		30.5029691806
1095PhosphorylationWLKRSSLSGLADGVE
HHHHHHCCCCCCCHH		33.4429691806
1119PhosphorylationRLSFIRQSSKVKFTS
HHHHHHCCCCCEECC		23.4427282143
1120PhosphorylationLSFIRQSSKVKFTSA
HHHHHCCCCCEECCC		32.8827282143
1137PhosphorylationLSEGGPGSGMENGRD
CCCCCCCCCCCCCCC		37.7921712546
1250UbiquitinationGHHVNITKKGLSRGR
CCCEECCCCCCCCCC		40.84-
1258PhosphorylationKGLSRGRSPIVGNKR
CCCCCCCCCCCCCHH		23.0823186163
1804PhosphorylationSSTSHRNYSFRRGSV
CCCCCCCCEECCCCE		14.78-
1805PhosphorylationSTSHRNYSFRRGSVW
CCCCCCCEECCCCEE		18.80-
1888PhosphorylationCLIEDPSTVLRHFLE
HHCCCHHHHHHHHHH		29.0224719451
2136PhosphorylationRLPSFPRSAIDAEFS
CCCCCCHHHHCCCCC		29.79-
2246PhosphorylationQVYSDYESNPQLRQA
HHHCCCCCCHHHHHH		47.8025332170
2495PhosphorylationEFRRPRESLLNICTE
HHHCHHHHHHHHHHH		39.1627732954
2533PhosphorylationLELLDVKSHMRLAEI
EEECCHHHHHHHHHH		23.5124719451
2543PhosphorylationRLAEIAHSLLKLAPY
HHHHHHHHHHHHCCC		26.7824719451
2554PhosphorylationLAPYDTQTMESRGLR
HCCCCCHHHHHHCHH		25.6224719451
2767PhosphorylationKNFMLESSPAHCSTP
CCCCCCCCCCCCCCC		19.4121888424
2772PhosphorylationESSPAHCSTPGDAGK
CCCCCCCCCCCCCCH		27.9821888424
2773PhosphorylationSSPAHCSTPGDAGKD
CCCCCCCCCCCCCHH		36.3621888424
2871PhosphorylationAENHEELSARQHIAD
CCCHHHHHHHHHHHH		25.3727762562
2911PhosphorylationILKEAVHSGSAYQGK
HHHHHHHCCCCCCCC		28.0430576142
2915PhosphorylationAVHSGSAYQGKTSIS
HHHCCCCCCCCCCEE		21.3530576142
2920PhosphorylationSAYQGKTSISTVGTS
CCCCCCCCEEECCCC		20.3030576142
2923PhosphorylationQGKTSISTVGTSTSA
CCCCCEEECCCCCCE		22.6830576142
2926PhosphorylationTSISTVGTSTSAYRL
CCEEECCCCCCEEEE		25.2130576142
2929PhosphorylationSTVGTSTSAYRLSLA
EECCCCCCEEEEEEE		24.07-
2931PhosphorylationVGTSTSAYRLSLATM
CCCCCCEEEEEEEEE		16.32-
2995 (in isoform 7)Phosphorylation-19.4328111955
2996 (in isoform 7)Phosphorylation-22.0828111955
2999 (in isoform 7)Phosphorylation-9.2428111955
3000 (in isoform 7)Phosphorylation-20.0928111955
3000 (in isoform 4)Phosphorylation-20.0928111955
3001 (in isoform 4)Phosphorylation-25.7928111955
3004 (in isoform 4)Phosphorylation-18.2028111955
3005 (in isoform 4)Phosphorylation-17.6228111955
3042PhosphorylationGSLSRVASIQSEPGQ
CCHHHHHHCCCCCCC		20.5024076635
3045PhosphorylationSRVASIQSEPGQQNL
HHHHHCCCCCCCCCE		44.0524076635
3077PhosphorylationPLLSRQKTQTEPRNR
HHHHCCCCCCCCCCC		32.1729978859
3079PhosphorylationLSRQKTQTEPRNRQG
HHCCCCCCCCCCCCC		53.8729978859
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of UNC80_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of UNC80_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of UNC80_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ZN687_HUMANZNF687physical
22939629
ZN827_HUMANZNF827physical
22939629
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of UNC80_HUMAN

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Related Literatures of Post-Translational Modification

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